{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,1,24]],"date-time":"2026-01-24T14:17:16Z","timestamp":1769264236321,"version":"3.49.0"},"reference-count":9,"publisher":"Wiley","issue":"9","license":[{"start":{"date-parts":[[2016,7,13]],"date-time":"2016-07-13T00:00:00Z","timestamp":1468368000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/501100004895","name":"European Social Fund","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100004895","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100004955","name":"\u00d6sterreichische Forschungsf\u00f6rderungsgesellschaft","doi-asserted-by":"publisher","award":["822782\/THERAPEP"],"award-info":[{"award-number":["822782\/THERAPEP"]}],"id":[{"id":"10.13039\/501100004955","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100002428","name":"Austrian Science Fund","doi-asserted-by":"publisher","award":["P20827\u2010B09"],"award-info":[{"award-number":["P20827\u2010B09"]}],"id":[{"id":"10.13039\/501100002428","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Experimental Dermatology"],"published-print":{"date-parts":[[2016,9]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>Allergic contact dermatitis (ACD) is an inflammatory skin disease induced by allergen exposure and characterized by erythema, oedema and immune cell infiltration. The sensory peptide galanin (GAL) and its three receptors (GAL<jats:sub>1\u20133<\/jats:sub>) are involved in regulating inflammation. As GAL and its receptors are expressed in human and murine skin and GAL expression is increased in oxazolone\u2010induced contact allergy, it could play a role in dermatitis. As GAL reduces neurogenic plasma extravasation in the mouse skin via GAL<jats:sub>3<\/jats:sub> activation, the role of GAL<jats:sub>3<\/jats:sub> in the oxazolone\u2010induced dermatitis model was explored. Following topical challenge with oxazolone, <jats:italic>GAL<\/jats:italic><jats:sub><jats:italic>3<\/jats:italic><\/jats:sub> gene\u2010deficient mice showed a trend towards reduced ear thickness. Plasma extravasation and neutrophil infiltration increased considerably upon oxazolone challenge in both GAL<jats:sub>3<\/jats:sub> knockout animals and wild\u2010type controls without any observable effect of the gene deletion. We conclude that a lack of GAL<jats:sub>3<\/jats:sub> does not influence oxazolone\u2010induced ACD.<\/jats:p>","DOI":"10.1111\/exd.13059","type":"journal-article","created":{"date-parts":[[2016,4,28]],"date-time":"2016-04-28T01:32:54Z","timestamp":1461807174000},"page":"725-727","source":"Crossref","is-referenced-by-count":4,"title":["Galanin 3 receptor\u2010deficient mice show no alteration in the oxazolone\u2010induced contact dermatitis phenotype"],"prefix":"10.1111","volume":"25","author":[{"given":"B\u00e1lint","family":"Botz","sequence":"first","affiliation":[{"name":"Department of Pharmacology and Pharmacotherapy School of Medicine J\u00e1nos Szent\u00e1gothai Research Centre Molecular Pharmacology Research Team University of P\u00e9cs P\u00e9cs Hungary"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Susanne M.","family":"Brunner","sequence":"additional","affiliation":[{"name":"Department of Pediatrics Laura Bassi Centre of Expertise\u2010THERAPEP Research Program for Receptor Biochemistry and Tumor Metabolism Paracelsus Medical University Salzburg Austria"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"\u00c1gnes","family":"Kem\u00e9ny","sequence":"additional","affiliation":[{"name":"Department of Pharmacology and Pharmacotherapy School of Medicine J\u00e1nos Szent\u00e1gothai Research Centre Molecular Pharmacology Research Team University of P\u00e9cs P\u00e9cs Hungary"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Erika","family":"Pint\u00e9r","sequence":"additional","affiliation":[{"name":"Department of Pharmacology and Pharmacotherapy School of Medicine J\u00e1nos Szent\u00e1gothai Research Centre Molecular Pharmacology Research Team University of P\u00e9cs P\u00e9cs Hungary"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jason J.","family":"McDougall","sequence":"additional","affiliation":[{"name":"Departments of Pharmacology and Anesthesia Pain Management &amp; Perioperative Medicine Dalhousie University Halifax NS Canada"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Barbara","family":"Kofler","sequence":"additional","affiliation":[{"name":"Department of Pediatrics Laura Bassi Centre of Expertise\u2010THERAPEP Research Program for Receptor Biochemistry and Tumor Metabolism Paracelsus Medical University Salzburg Austria"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Zsuzsanna","family":"Helyes","sequence":"additional","affiliation":[{"name":"Department of Pharmacology and Pharmacotherapy School of Medicine J\u00e1nos Szent\u00e1gothai Research Centre Molecular Pharmacology Research Team University of P\u00e9cs P\u00e9cs Hungary"},{"name":"MTA\u2010PTE NAP B Chronic Pain Research Group P\u00e9cs Hungary"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2016,7,13]]},"reference":[{"key":"e_1_2_9_2_1","first-page":"284","volume":"14","author":"Saint\u2010Mezard P","year":"2004","journal-title":"Eur J Dermatol"},{"key":"e_1_2_9_3_1","doi-asserted-by":"publisher","DOI":"10.1111\/exd.12622"},{"key":"e_1_2_9_4_1","doi-asserted-by":"publisher","DOI":"10.1124\/pr.112.006536"},{"key":"e_1_2_9_5_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.0022-202X.2004.22418.x"},{"key":"e_1_2_9_6_1","doi-asserted-by":"publisher","DOI":"10.1080\/00015550410017290"},{"key":"e_1_2_9_7_1","doi-asserted-by":"publisher","DOI":"10.1038\/sj.jid.5700569"},{"key":"e_1_2_9_8_1","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.1318066111"},{"key":"e_1_2_9_9_1","doi-asserted-by":"publisher","DOI":"10.1111\/exd.12067"},{"key":"e_1_2_9_10_1","doi-asserted-by":"publisher","DOI":"10.1111\/apha.12444"}],"container-title":["Experimental Dermatology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1111%2Fexd.13059","content-type":"unspecified","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/exd.13059","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,9,24]],"date-time":"2023-09-24T12:24:39Z","timestamp":1695558279000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1111\/exd.13059"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2016,7,13]]},"references-count":9,"journal-issue":{"issue":"9","published-print":{"date-parts":[[2016,9]]}},"alternative-id":["10.1111\/exd.13059"],"URL":"https:\/\/doi.org\/10.1111\/exd.13059","archive":["Portico"],"relation":{},"ISSN":["0906-6705","1600-0625"],"issn-type":[{"value":"0906-6705","type":"print"},{"value":"1600-0625","type":"electronic"}],"subject":[],"published":{"date-parts":[[2016,7,13]]}}}