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The clinical heterogeneity of <jats:styled-content style=\"fixed-case\">FFA<\/jats:styled-content>, its apparent rarity and investigators' suboptimal access to phenotypically consistent patient cohorts may all have had a negative impact on delineating disease pathogenesis. Moreover, there is a relative paucity of epidemiological, interventional and basic research studies, and there have been no advances in translational therapeutics, unlike for other inflammatory dermatoses, such as alopecia areata (<jats:styled-content style=\"fixed-case\">AA<\/jats:styled-content>). Dermatologists anecdotally describe an increasing incidence in <jats:styled-content style=\"fixed-case\">FFA<\/jats:styled-content> over the last decade, which has led to the notion that the disorder may be induced by unknown environmental triggers. On the other hand, segregation of <jats:styled-content style=\"fixed-case\">FFA<\/jats:styled-content> in some families lends support to an unexplored genetic element implicated in disease pathogenesis. We herein review what is known about the pathobiology of <jats:styled-content style=\"fixed-case\">FFA<\/jats:styled-content> and formulate working hypotheses to advance insight into this intriguing hair disorder.<\/jats:p>","DOI":"10.1111\/exd.13071","type":"journal-article","created":{"date-parts":[[2016,5,21]],"date-time":"2016-05-21T14:46:57Z","timestamp":1463842017000},"page":"847-852","source":"Crossref","is-referenced-by-count":66,"title":["Frontal fibrosing alopecia: reflections and hypotheses on aetiology and pathogenesis"],"prefix":"10.1111","volume":"25","author":[{"given":"Christos","family":"Tziotzios","sequence":"first","affiliation":[{"name":"St John's Institute of Dermatology King's College London (Guy's Campus)  London UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Catherine M.","family":"Stefanato","sequence":"additional","affiliation":[{"name":"Dermatopathology St John's Institute of Dermatology St Thomas' Hospital  London 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