{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,30]],"date-time":"2026-07-30T06:14:22Z","timestamp":1785392062640,"version":"3.55.0"},"reference-count":21,"publisher":"Wiley","issue":"S3","license":[{"start":{"date-parts":[[2016,8,18]],"date-time":"2016-08-18T00:00:00Z","timestamp":1471478400000},"content-version":"vor","delay-in-days":17,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"name":"KOS\u00c9 Corporation"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Experimental Dermatology"],"published-print":{"date-parts":[[2016,8]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>It is well known that the trigger for actinic keratosis (AK) mainly depends on <jats:styled-content style=\"fixed-case\">UV<\/jats:styled-content> exposure. We evaluated the effects of long\u2010term use of sunscreen on the histopathological and dermoscopic changes of AK in aged patients. Eighteen months use of sunscreen produced no change in the number of actinic keratoses or the advancement of histological grade. Although a significant decrease was not observed in the number of positive cells of p53, Ki\u201067 and <jats:styled-content style=\"fixed-case\">COX<\/jats:styled-content>\u20102 of the subjects who used sunscreen for 18\u00a0months, the downward tendencies of these proteins were observed. The continued use of sunscreen decreased the number of <jats:styled-content style=\"fixed-case\">CD<\/jats:styled-content>31\u2010positive vessels significantly using the Chalkley method, and a significant improvement in scaling and vessel dots was found by dermoscopic study. Moreover, a relationship was found in the amount of sunscreen use and the number of actinic keratoses. Considering these results, it was thought that application of sunscreen reduces the risk of advancement of AK to higher grade AK and squamous cell carcinoma.<\/jats:p>","DOI":"10.1111\/exd.13081","type":"journal-article","created":{"date-parts":[[2016,8,19]],"date-time":"2016-08-19T02:40:26Z","timestamp":1471574426000},"page":"34-40","source":"Crossref","is-referenced-by-count":4,"title":["The continued use of sunscreen prevents the development of actinic keratosis in aged Japanese subjects"],"prefix":"10.1111","volume":"25","author":[{"given":"Kayo","family":"Kunimoto","sequence":"first","affiliation":[{"name":"Department of Dermatology  Faculty of Medicine Wakayama Medical University  Wakayama Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Fukumi","family":"Furukawa","sequence":"additional","affiliation":[{"name":"Department of Dermatology  Faculty of Medicine Wakayama Medical University  Wakayama 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