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Our objective was to analyze the effect of S42909, a potent NADPH oxidase inhibitor activity, with vascular anti\u2010inflammatory properties. An ischemic rabbit ear ulcer model (24 New Zealand white rabbits) was used to evaluate the reepithelialization\/contraction areas, anti\u2010\/pro\u2010inflammatory cytokines mRNA (TGF\u2010\u03b21\/IL\u201010\/IFN\u2010\u03b3\/VEGF) by qRT\u2010PCR, collagen I\/III deposition, and neovascularization (TGF\u2010\u03b21\/VEGF) by morphological and immunohistochemical analyses. Three different doses were administered by gavage for 2\u00a0weeks: 10 and 30\u00a0mg\/kg\/d in self\u2010microemulsion drug delivery system (SMEDDS) and 100\u00a0mg\/kg\/d in arabic gum. Each vehicle was used as control. No signs of infection or necrosis were found. Reepithelialization was almost complete whatever the groups reaching 95% at the dose of 100\u00a0mg\/kg. Wound contraction was significantly reduced in all S42909\u2010treated groups. A significant increase in anti\u2010inflammatory cytokines TGF\u2010\u03b21 mRNA and IL\u201010 mRNA was observed at the dose of 100 and 30\u00a0mg\/kg\/d, respectively. No changes were observed in pro\u2010inflammatory factors INF\u2010\u03b3 and VEGF mRNA. Ischemic skin wound areas had scarce expression of collagen I\/III and showed rich glycosaminoglycans content. Treatment increased the collagen deposition and TGF\u2010\u03b21 protein expression and decreased glycosaminoglycan content dose dependently; however, no effect in VEGF was appreciated. Therefore, our results indicate that S42909 improved healing process by dampening excessive inflammation and facilitating collagen deposition without wound contraction phenomena. S42909 might be a promising therapy to treat chronic wounds as venous leg ulcers.<\/jats:p>","DOI":"10.1111\/exd.13099","type":"journal-article","created":{"date-parts":[[2016,6,1]],"date-time":"2016-06-01T23:47:21Z","timestamp":1464824841000},"page":"148-155","source":"Crossref","is-referenced-by-count":12,"title":["Effects of a novel NADPH oxidase inhibitor (S42909) on wound healing in an experimental ischemic excisional skin model"],"prefix":"10.1111","volume":"26","author":[{"given":"Sandra","family":"Sotomayor","sequence":"first","affiliation":[{"name":"Department of Medicine and Medical Specialities Faculty of Medicine and Health Sciences University of Alcal\u00e1  Alcal\u00e1 de Henares Madrid Spain"},{"name":"Biomedical Research Networking Center on Bioengineering Biomaterials and Nanomedicine (CIBER\u2010BBN)  Madrid Spain"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-1623-4384","authenticated-orcid":false,"given":"Gemma","family":"Pascual","sequence":"additional","affiliation":[{"name":"Department of Medicine and Medical Specialities Faculty of Medicine and Health Sciences University of Alcal\u00e1  Alcal\u00e1 de Henares Madrid Spain"},{"name":"Biomedical Research Networking Center on Bioengineering Biomaterials and Nanomedicine (CIBER\u2010BBN)  Madrid Spain"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Vanessa","family":"Blanc\u2010Guillemaud","sequence":"additional","affiliation":[{"name":"Institut de Recherches Internationales SERVIER (I.R.I.S.)  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