{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,29]],"date-time":"2026-09-29T14:24:53Z","timestamp":1790691893109,"version":"4.1.0"},"reference-count":34,"publisher":"Wiley","issue":"10","license":[{"start":{"date-parts":[[2016,8,3]],"date-time":"2016-08-03T00:00:00Z","timestamp":1470182400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/501100003503","name":"Nederlandse Brandwonden Stichting","doi-asserted-by":"publisher","award":["12.107"],"award-info":[{"award-number":["12.107"]}],"id":[{"id":"10.13039\/501100003503","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Experimental Dermatology"],"published-print":{"date-parts":[[2016,10]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>This study aimed to examine changes in the inflammatory response in early hypertrophic compared to normal wound healing. The immune system is thought to be involved in hypertrophic scar formation. However, the exact mechanism and time of onset of the derailment remain unknown. In a prospective observational study, skin biopsies were taken directly postwounding and 3\u00a0hours later from patients who had elective cardiothoracic surgery. The skin biopsies were analysed for <jats:styled-content style=\"fixed-case\">mRNA<\/jats:styled-content>, proteins and cells involved in the early inflammatory phase of wound healing. The endpoint was scar outcome (hypertrophic (<jats:styled-content style=\"fixed-case\">HTS<\/jats:styled-content>) or normal (<jats:styled-content style=\"fixed-case\">NTS<\/jats:styled-content>)) at one year after surgery. There were significant differences between the <jats:styled-content style=\"fixed-case\">NTS<\/jats:styled-content> and <jats:styled-content style=\"fixed-case\">HTS<\/jats:styled-content> groups regarding the fold changes of <jats:styled-content style=\"fixed-case\">mRNA<\/jats:styled-content> expression of P\u2010selectin during surgery. Postoperative skin concentrations of inflammatory proteins <jats:styled-content style=\"fixed-case\">IL<\/jats:styled-content>\u20106, <jats:styled-content style=\"fixed-case\">IL<\/jats:styled-content>\u20108 and <jats:styled-content style=\"fixed-case\">CCL<\/jats:styled-content>2 were significantly lower in the <jats:styled-content style=\"fixed-case\">HTS<\/jats:styled-content> compared to the <jats:styled-content style=\"fixed-case\">NTS<\/jats:styled-content> group. Also, a trend of higher pre\u2010operative M2 macrophage numbers was observed in the <jats:styled-content style=\"fixed-case\">HTS<\/jats:styled-content> group. Neutrophil numbers increased equally during surgery in both groups. The increase of P\u2010selectin <jats:styled-content style=\"fixed-case\">mRNA<\/jats:styled-content> in hypertrophic wound healing could affect leucocyte migration. The decreased concentrations of inflammatory proteins in hypertrophic wound healing indicate a reduced inflammatory response, which has consequences for the treatment of hypertrophic scarring during the early inflammatory phase. In a conclusion, alterations of wound healing associated with hypertrophic scarring are visible as early as 3\u00a0hours postwounding and include a reduced rather than increased inflammatory protein response.<\/jats:p>","DOI":"10.1111\/exd.13100","type":"journal-article","created":{"date-parts":[[2016,6,1]],"date-time":"2016-06-01T23:46:08Z","timestamp":1464824768000},"page":"797-804","source":"Crossref","is-referenced-by-count":44,"title":["Inhibited early immunologic response is associated with hypertrophic scarring"],"prefix":"10.1111","volume":"25","author":[{"given":"Liselotte","family":"Butzelaar","sequence":"first","affiliation":[{"name":"Department of Plastic\u2010, Reconstructive\u2010 and Hand Surgery VU Medical Center Amsterdam The Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Dennis P. 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