{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,20]],"date-time":"2026-09-20T08:34:30Z","timestamp":1789893270165,"version":"4.0.1"},"reference-count":43,"publisher":"Wiley","issue":"12","license":[{"start":{"date-parts":[[2017,1,9]],"date-time":"2017-01-09T00:00:00Z","timestamp":1483920000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/501100001691","name":"Japan Society for the Promotion of Science","doi-asserted-by":"publisher","award":["25461682"],"award-info":[{"award-number":["25461682"]}],"id":[{"id":"10.13039\/501100001691","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Experimental Dermatology"],"published-print":{"date-parts":[[2017,12]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>Pemphigus vulgaris (<jats:styled-content style=\"fixed-case\">PV<\/jats:styled-content>) and bullous pemphigoid (<jats:styled-content style=\"fixed-case\">BP<\/jats:styled-content>) are autoimmune blistering diseases, and substantial numbers of <jats:styled-content style=\"fixed-case\">CD<\/jats:styled-content>163<jats:sup>+<\/jats:sup> tissue\u2010associated macrophages (<jats:styled-content style=\"fixed-case\">TAM<\/jats:styled-content>s) are detected in both diseases. <jats:styled-content style=\"fixed-case\">PV<\/jats:styled-content> and <jats:styled-content style=\"fixed-case\">BP<\/jats:styled-content> possess different subsets of helper T cells, suggesting that the cytokine profiles of <jats:styled-content style=\"fixed-case\">PV<\/jats:styled-content> and <jats:styled-content style=\"fixed-case\">BP<\/jats:styled-content> might be different. The purpose of this study was to investigate the microenvironment of lesional skin and serum of <jats:styled-content style=\"fixed-case\">PV<\/jats:styled-content> and <jats:styled-content style=\"fixed-case\">BP<\/jats:styled-content> patients, focusing on the immunomodulatory factors related to <jats:styled-content style=\"fixed-case\">TAM<\/jats:styled-content>s, such as periostin (<jats:styled-content style=\"fixed-case\">POSTN<\/jats:styled-content>), chemokines, cytokines and matrix metalloproteinases (MMPs). We first performed immunohistological staining of <jats:styled-content style=\"fixed-case\">POSTN<\/jats:styled-content> in <jats:styled-content style=\"fixed-case\">PV<\/jats:styled-content> and <jats:styled-content style=\"fixed-case\">BP<\/jats:styled-content> lesions. <jats:styled-content style=\"fixed-case\">POSTN<\/jats:styled-content> was prominent in the superficial dermis in both <jats:styled-content style=\"fixed-case\">PV<\/jats:styled-content> and <jats:styled-content style=\"fixed-case\">BP<\/jats:styled-content> lesions. Next, to validate the activation of <jats:styled-content style=\"fixed-case\">CD<\/jats:styled-content>163<jats:sup>+<\/jats:sup> <jats:styled-content style=\"fixed-case\">TAM<\/jats:styled-content>s in <jats:styled-content style=\"fixed-case\">PV<\/jats:styled-content> and <jats:styled-content style=\"fixed-case\">BP<\/jats:styled-content> patients, we examined the serum levels of soluble (s)<jats:styled-content style=\"fixed-case\">CD<\/jats:styled-content>163. The serum <jats:styled-content style=\"fixed-case\">sCD<\/jats:styled-content>163 levels in <jats:styled-content style=\"fixed-case\">PV<\/jats:styled-content> and <jats:styled-content style=\"fixed-case\">BP<\/jats:styled-content> patients are significantly higher than in healthy controls. To further elucidate the molecular mechanisms of the effects of <jats:styled-content style=\"fixed-case\">POSTN<\/jats:styled-content> on <jats:styled-content style=\"fixed-case\">CD<\/jats:styled-content>163<jats:sup>+<\/jats:sup> <jats:styled-content style=\"fixed-case\">TAM<\/jats:styled-content>s in <jats:styled-content style=\"fixed-case\">PV<\/jats:styled-content> and <jats:styled-content style=\"fixed-case\">BP<\/jats:styled-content>, we examined chemokines, MMPs and cytokines selected by <jats:styled-content style=\"fixed-case\">DNA<\/jats:styled-content> microarray database. The serum <jats:styled-content style=\"fixed-case\">CXCL<\/jats:styled-content>5 levels from <jats:styled-content style=\"fixed-case\">PV<\/jats:styled-content> patients are significantly higher than those in <jats:styled-content style=\"fixed-case\">BP<\/jats:styled-content> patients and healthy controls. The <jats:styled-content style=\"fixed-case\">IL<\/jats:styled-content>\u201036\u03b3 expression on infiltrating macrophages was prominent only in the lesional skin of <jats:styled-content style=\"fixed-case\">PV<\/jats:styled-content>, while the <jats:styled-content style=\"fixed-case\">MMP<\/jats:styled-content>12 deposition was detected in both <jats:styled-content style=\"fixed-case\">PV<\/jats:styled-content> and <jats:styled-content style=\"fixed-case\">BP<\/jats:styled-content> lesions. Our results shed light on the novel pathogenesis of <jats:styled-content style=\"fixed-case\">PV<\/jats:styled-content> through <jats:styled-content style=\"fixed-case\">CD<\/jats:styled-content>163<jats:sup>+<\/jats:sup> <jats:styled-content style=\"fixed-case\">TAM<\/jats:styled-content>s.<\/jats:p>","DOI":"10.1111\/exd.13157","type":"journal-article","created":{"date-parts":[[2016,8,8]],"date-time":"2016-08-08T18:50:46Z","timestamp":1470682246000},"page":"1193-1198","source":"Crossref","is-referenced-by-count":41,"title":["A possible interaction between periostin and <scp>CD<\/scp>163<sup>+<\/sup> skin\u2010resident macrophages in pemphigus vulgaris and bullous pemphigoid"],"prefix":"10.1111","volume":"26","author":[{"given":"Taku","family":"Fujimura","sequence":"first","affiliation":[{"name":"Department of Dermatology Tohoku University Graduate School of Medicine Sendai 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