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The recently discovered enzymes endoglycosidase S (EndoS) and IgG\u2010degrading enzyme (IdeS) of <jats:italic>Streptococcus pyogenes<\/jats:italic> are able to modulate the interaction between IgG antibodies and the Fc receptors, by hydrolysis of the glycan associated with the heavy chain of the IgG molecule (EndoS), or cleavage in the hinge region of the heavy IgG chain (IdeS). In this work, we investigated their ability to inhibit damage mediated by skin\u2010bound antibodies in vivo in two different experimental models, the Arthus reaction, and epidermolysis bullosa acquisita, an autoimmune blistering skin disease associated with autoantibodies against type <jats:styled-content style=\"fixed-case\">VII<\/jats:styled-content> collagen. We demonstrate that both enzymes efficiently interfere with IgG\u2010mediated proinflammatory processes, offering a great asset to specifically target pathological IgG antibodies in the skin and holding great promise for future applications in human therapy.<\/jats:p>","DOI":"10.1111\/exd.13163","type":"journal-article","created":{"date-parts":[[2016,8,11]],"date-time":"2016-08-11T14:00:11Z","timestamp":1470924011000},"page":"691-696","source":"Crossref","is-referenced-by-count":20,"title":["In vivo enzymatic modulation of IgG antibodies prevents immune complex\u2010dependent skin injury"],"prefix":"10.1111","volume":"26","author":[{"given":"Sidonia","family":"Mihai","sequence":"first","affiliation":[{"name":"Department of Biology Institute of Genetics University of Erlangen\u2010Nuremberg  Erlangen Germany"},{"name":"Department of Clinical Chemistry University Hospital Erlangen  Erlangen Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Heike","family":"Albert","sequence":"additional","affiliation":[{"name":"Department of Biology Institute of Genetics University of Erlangen\u2010Nuremberg  Erlangen Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ralf J.","family":"Ludwig","sequence":"additional","affiliation":[{"name":"Department of Dermatology University of L\u00fcbeck  L\u00fcbeck Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hiroaki","family":"Iwata","sequence":"additional","affiliation":[{"name":"Department of Dermatology University of L\u00fcbeck  L\u00fcbeck Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lars","family":"Bj\u00f6rck","sequence":"additional","affiliation":[{"name":"Division of Infection Medicine Department of Clinical Sciences Lund University  Lund Sweden"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mattias","family":"Collin","sequence":"additional","affiliation":[{"name":"Division of Infection Medicine Department of Clinical Sciences Lund University  Lund Sweden"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Falk","family":"Nimmerjahn","sequence":"additional","affiliation":[{"name":"Department of Biology Institute of Genetics University of Erlangen\u2010Nuremberg  Erlangen 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