{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,10,15]],"date-time":"2025-10-15T17:41:58Z","timestamp":1760550118996},"reference-count":33,"publisher":"Wiley","issue":"3","license":[{"start":{"date-parts":[[2017,2,2]],"date-time":"2017-02-02T00:00:00Z","timestamp":1485993600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/501100001691","name":"Japan Society for the Promotion of Science","doi-asserted-by":"publisher","award":["25350112"],"award-info":[{"award-number":["25350112"]}],"id":[{"id":"10.13039\/501100001691","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100009475","name":"Fuji Foundation for Protein Research","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100009475","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Experimental Dermatology"],"published-print":{"date-parts":[[2017,3]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>Soyasaponins (<jats:styled-content style=\"fixed-case\">SS<\/jats:styled-content>s) abundant in soybean have anti\u2010inflammatory activities; however, their therapeutic effects on allergic contact dermatitis (<jats:styled-content style=\"fixed-case\">ACD<\/jats:styled-content>) remain unknown. To assess the effects of <jats:styled-content style=\"fixed-case\">SS<\/jats:styled-content>\u2010enriched diets on <jats:styled-content style=\"fixed-case\">ACD<\/jats:styled-content>, we used a mouse model of contact hypersensitivity (<jats:styled-content style=\"fixed-case\">CHS<\/jats:styled-content>). Mice were fed low\u2010dose or high\u2010dose <jats:styled-content style=\"fixed-case\">SS<\/jats:styled-content>\u2010containing diets for 3\u00a0weeks prior to <jats:styled-content style=\"fixed-case\">CHS<\/jats:styled-content> induction with 2,4\u2010dinitrofluorobenzene (<jats:styled-content style=\"fixed-case\">DNFB<\/jats:styled-content>). The low\u2010dose <jats:styled-content style=\"fixed-case\">SS<\/jats:styled-content> diet attenuated <jats:styled-content style=\"fixed-case\">DNFB<\/jats:styled-content>\u2010induced ear swelling and tissue oedema, and reduced the number of infiltrating Gr\u20101\u2010positive myeloid cells. Low\u2010dose, but not high\u2010dose, <jats:styled-content style=\"fixed-case\">SS<\/jats:styled-content>s decreased chemokine (C\u2010X\u2010C motif) ligand 2 (<jats:styled-content style=\"fixed-case\">CXCL<\/jats:styled-content>2) and triggering receptor expressed on myeloid cells (<jats:styled-content style=\"fixed-case\">TREM<\/jats:styled-content>)\u20101 production in ear tissues, compared to a control. Taxonomic 16S <jats:styled-content style=\"fixed-case\">rRNA<\/jats:styled-content> analysis revealed significant alterations in faecal microbiota caused by <jats:styled-content style=\"fixed-case\">CHS<\/jats:styled-content>, which were reversed by low\u2010dose <jats:styled-content style=\"fixed-case\">SS<\/jats:styled-content>s. The low\u2010dose <jats:styled-content style=\"fixed-case\">SS<\/jats:styled-content> and non\u2010<jats:styled-content style=\"fixed-case\">CHS<\/jats:styled-content> groups clustered together, while the high\u2010dose <jats:styled-content style=\"fixed-case\">SS<\/jats:styled-content> group split between <jats:styled-content style=\"fixed-case\">CHS<\/jats:styled-content> and non\u2010<jats:styled-content style=\"fixed-case\">CHS<\/jats:styled-content> clusters. Our results demonstrated that low\u2010dose <jats:styled-content style=\"fixed-case\">SS<\/jats:styled-content>s alleviated <jats:styled-content style=\"fixed-case\">CHS<\/jats:styled-content> symptoms by attenuating inflammation and improving the intestinal microbiota composition, suggesting that dietary <jats:styled-content style=\"fixed-case\">SS<\/jats:styled-content>s may have beneficial effects on <jats:styled-content style=\"fixed-case\">ACD<\/jats:styled-content>.<\/jats:p>","DOI":"10.1111\/exd.13205","type":"journal-article","created":{"date-parts":[[2016,9,13]],"date-time":"2016-09-13T07:08:43Z","timestamp":1473750523000},"page":"249-254","source":"Crossref","is-referenced-by-count":13,"title":["Inhibitory effects of dietary soyasaponin on 2,4\u2010dinitrofluorobenzene\u2010induced contact hypersensitivity in mice"],"prefix":"10.1111","volume":"26","author":[{"given":"Takao","family":"Nagano","sequence":"first","affiliation":[{"name":"Department of Clinical Nutrition Kawasaki University of Medical Welfare  Okayama Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Mitsuru","family":"Katase","sequence":"additional","affiliation":[{"name":"Quality Assurance Department Fuji Oil Holdings Inc.  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Ibaraki Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Mineki","family":"Saito","sequence":"additional","affiliation":[{"name":"Department of Microbiology Kawasaki Medical School  Okayama Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Tsukasa","family":"Matsuda","sequence":"additional","affiliation":[{"name":"Department of Applied Molecular Bioscience Nagoya University  Aichi Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2017,2,2]]},"reference":[{"key":"e_1_2_8_2_1","doi-asserted-by":"publisher","DOI":"10.1021\/jf100901b"},{"key":"e_1_2_8_3_1","doi-asserted-by":"publisher","DOI":"10.1002\/jsfa.2740370715"},{"key":"e_1_2_8_4_1","doi-asserted-by":"publisher","DOI":"10.1248\/yakushi1947.104.3_275"},{"key":"e_1_2_8_5_1","first-page":"49","volume":"48","author":"Lee Y. B.","year":"2005","journal-title":"J. Appl. Biol. 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