{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,2]],"date-time":"2026-09-02T00:30:38Z","timestamp":1788309038477,"version":"build-2803163510"},"reference-count":40,"publisher":"Wiley","issue":"5","license":[{"start":{"date-parts":[[2017,3,23]],"date-time":"2017-03-23T00:00:00Z","timestamp":1490227200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/100009821","name":"Society for Women\u2019s Health Research","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100009821","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Experimental Dermatology"],"published-print":{"date-parts":[[2017,5]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>Significant decreases in hormonal levels at menopause induce physiological and functional discomfort in the skin. Representative changes at menopause are based on so\u2010called dry skin. However, there is no evidence to explain the mechanism, even though hydration of the stratum corneum (<jats:styled-content style=\"fixed-case\">SC<\/jats:styled-content>) in women at menopause is comparable with that at premenopause but is enhanced by hormone replacement therapy. This study objective was to evaluate structural and functional changes in the <jats:styled-content style=\"fixed-case\">SC<\/jats:styled-content> in ovariectomized mice model of menopause. Hydration of the <jats:styled-content style=\"fixed-case\">SC<\/jats:styled-content>, recovery of the permeability barrier function, integrity and cohesion of the <jats:styled-content style=\"fixed-case\">SC<\/jats:styled-content>, and irritant dermatitis were analysed in mice that underwent ovariectomy with or without replacement of 17\u00df\u2010estradiol. In ovariectomized mice, hydration of the <jats:styled-content style=\"fixed-case\">SC<\/jats:styled-content> was reduced, recovery of permeability barrier function after acute disruption was impaired, and integrity of the <jats:styled-content style=\"fixed-case\">SC<\/jats:styled-content> was weakened and was associated with increased cohesion and increased levels of irritant dermatitis. Oestrogen replacement treatment restored all changes. Immunohistochemistry revealed reduced levels of expression of desmoglein\u20101 and differentiation markers of epidermis in ovariectomized mice compared with control mice and mice with oestrogen replacement treatment. These changes might be directly associated with weakened integrity and impaired permeability barrier function of the <jats:styled-content style=\"fixed-case\">SC<\/jats:styled-content> in ovariectomized mice. This study results reveal that so\u2010called dry skin at menopause is caused by not only lower hydration of the <jats:styled-content style=\"fixed-case\">SC<\/jats:styled-content> but also complicated structural and functional changes in the <jats:styled-content style=\"fixed-case\">SC<\/jats:styled-content> and skin.<\/jats:p>","DOI":"10.1111\/exd.13214","type":"journal-article","created":{"date-parts":[[2016,9,27]],"date-time":"2016-09-27T15:04:59Z","timestamp":1474988699000},"page":"394-401","source":"Crossref","is-referenced-by-count":21,"title":["Physiological and functional changes in the stratum corneum restored by oestrogen in an ovariectomized mice model of climacterium"],"prefix":"10.1111","volume":"26","author":[{"given":"Yue","family":"Chen","sequence":"first","affiliation":[{"name":"Department of Dermatology Dokkyo Medical University Koshigaya Hospital  Koshigaya Saitama Japan"},{"name":"Department of Dermatology Tokyo Medical and Dental University  Tokyo Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hiroo","family":"Yokozeki","sequence":"additional","affiliation":[{"name":"Department of Dermatology Tokyo Medical and Dental University  Tokyo Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kazumoto","family":"Katagiri","sequence":"additional","affiliation":[{"name":"Department of Dermatology Dokkyo Medical University Koshigaya Hospital  Koshigaya Saitama Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2017,3,23]]},"reference":[{"key":"e_1_2_9_2_1","unstructured":"National Institute for Health and Care Excellence Menopause: Full Guideline. London: 2015 National Collaborating Centre for Women's and Children's Health; 2015 Nov 12."},{"key":"e_1_2_9_3_1","volume-title":"Menopausal Symptoms: Comparative Effectiveness of Therapies","author":"Grant M. D.","year":"2015"},{"key":"e_1_2_9_4_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jaad.2004.08.039"},{"key":"e_1_2_9_4_2","doi-asserted-by":"publisher","DOI":"10.2165\/00128071-200102030-00003"},{"key":"e_1_2_9_4_3","doi-asserted-by":"publisher","DOI":"10.1111\/j.1473-2130.2004.00056.x"},{"key":"e_1_2_9_5_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0378-5122(97)00079-0"},{"key":"e_1_2_9_5_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1600-0536.2009.01621.x"},{"key":"e_1_2_9_6_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.0022-202X.2004.23545.x"},{"key":"e_1_2_9_7_1","doi-asserted-by":"publisher","DOI":"10.1093\/oxfordjournals.bmb.a072551"},{"key":"e_1_2_9_8_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.0022-202X.2005.23736.x"},{"key":"e_1_2_9_9_1","doi-asserted-by":"publisher","DOI":"10.2165\/00128071-200304060-00001"},{"key":"e_1_2_9_10_1","doi-asserted-by":"crossref","first-page":"339","DOI":"10.1001\/archderm.1997.03890390077010","volume":"133","author":"Dunn L. B.","year":"1997","journal-title":"Arch. Dermatol."},{"key":"e_1_2_9_11_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0002-9378(94)70242-X"},{"key":"e_1_2_9_11_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.0022-202X.2004.12645.x"},{"key":"e_1_2_9_12_1","doi-asserted-by":"publisher","DOI":"10.1038\/nm1197-1209"},{"key":"e_1_2_9_13_1","doi-asserted-by":"publisher","DOI":"10.1046\/j.1523-1747.2002.19627.x"},{"key":"e_1_2_9_14_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1471-4159.2009.06502.x"},{"key":"e_1_2_9_15_1","doi-asserted-by":"publisher","DOI":"10.1097\/01.wcb.0000037991.07114.4e"},{"key":"e_1_2_9_16_1","doi-asserted-by":"publisher","DOI":"10.2353\/ajpath.2008.070439"},{"key":"e_1_2_9_17_1","doi-asserted-by":"publisher","DOI":"10.1210\/en.2011-1501"},{"key":"e_1_2_9_18_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jaci.2012.01.068"},{"key":"e_1_2_9_19_1","doi-asserted-by":"publisher","DOI":"10.1038\/sj.jid.5701138"},{"key":"e_1_2_9_20_1","doi-asserted-by":"publisher","DOI":"10.1111\/1523-1747.ep12325538"},{"key":"e_1_2_9_21_1","doi-asserted-by":"publisher","DOI":"10.1172\/JCI1647"},{"key":"e_1_2_9_22_1","doi-asserted-by":"publisher","DOI":"10.1038\/ncomms11596"},{"key":"e_1_2_9_23_1","doi-asserted-by":"publisher","DOI":"10.1111\/1523-1747.ep12497866"},{"key":"e_1_2_9_24_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.0022-202X.2005.23651.x"},{"key":"e_1_2_9_25_1","doi-asserted-by":"publisher","DOI":"10.1111\/all.12051"},{"key":"e_1_2_9_26_1","doi-asserted-by":"publisher","DOI":"10.1046\/j.1523-1747.2003.12365.x"},{"key":"e_1_2_9_27_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.clindermatol.2011.08.014"},{"key":"e_1_2_9_28_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00795-010-0513-4"},{"key":"e_1_2_9_29_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00441-014-2019-1"},{"key":"e_1_2_9_30_1","doi-asserted-by":"publisher","DOI":"10.1091\/mbc.E07-02-0124"},{"key":"e_1_2_9_31_1","doi-asserted-by":"publisher","DOI":"10.1159\/000249351"},{"key":"e_1_2_9_32_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-4362.1981.tb04335.x"},{"key":"e_1_2_9_33_1","first-page":"120","volume":"2003","author":"Kanda N.","journal-title":"J. Invest. Dermatol."},{"key":"e_1_2_9_33_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.0022-202X.2004.23231.x"},{"key":"e_1_2_9_34_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2133.2007.08115.x"},{"key":"e_1_2_9_35_1","first-page":"59","article-title":"Dermatology 2003, 206, 110\u2010112, D. Kemmett, M","volume":"125","author":"Kiriyama K.","year":"1991","journal-title":"J. Tidman Br. J. Dermatol."},{"key":"e_1_2_9_36_1","doi-asserted-by":"publisher","DOI":"10.1111\/1523-1747.ep12456427"}],"container-title":["Experimental Dermatology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1111%2Fexd.13214","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1111%2Fexd.13214","content-type":"unspecified","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/exd.13214","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,9,23]],"date-time":"2023-09-23T15:09:58Z","timestamp":1695481798000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1111\/exd.13214"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2017,3,23]]},"references-count":40,"journal-issue":{"issue":"5","published-print":{"date-parts":[[2017,5]]}},"alternative-id":["10.1111\/exd.13214"],"URL":"https:\/\/doi.org\/10.1111\/exd.13214","archive":["Portico"],"relation":{},"ISSN":["0906-6705","1600-0625"],"issn-type":[{"value":"0906-6705","type":"print"},{"value":"1600-0625","type":"electronic"}],"subject":[],"published":{"date-parts":[[2017,3,23]]}}}