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Using transcriptional reporter mice we analyzed cellular sources of IL<\/jats:styled-content>\u201010 during contact hypersensitivity (CHS<\/jats:styled-content>) and identified IL<\/jats:styled-content>\u201010 expressing CD<\/jats:styled-content>8+<\/jats:sup> T cells in the skin that are antigen\u2010specific, display PD<\/jats:styled-content>\u20101, an effector memory phenotype, and IL<\/jats:styled-content>\u201010 expression comparable to that of CD<\/jats:styled-content>4+<\/jats:sup> T cells. However, in mice with a selective IL<\/jats:styled-content>\u201010 deficiency in CD<\/jats:styled-content>8+<\/jats:sup> T cells CHS<\/jats:styled-content> responses were comparable to that of controls, even in the absence of CD<\/jats:styled-content>4+<\/jats:sup> cells, suggesting that CD<\/jats:styled-content>8+<\/jats:sup> T cell\u2010derived IL<\/jats:styled-content>\u201010 does not contribute significantly to the resolution of CHS<\/jats:styled-content> responses.<\/jats:p>","DOI":"10.1111\/exd.13237","type":"journal-article","created":{"date-parts":[[2016,10,13]],"date-time":"2016-10-13T04:42:04Z","timestamp":1476333724000},"page":"449-451","source":"Crossref","is-referenced-by-count":7,"title":["Contact allergens induce CD8+<\/sup> T cell\u2010derived interleukin 10 that appears dispensable for regulation of contact hypersensitivity"],"prefix":"10.1111","volume":"26","author":[{"given":"Anja","family":"Dolch","sequence":"first","affiliation":[{"name":"Allergy Research Group Department of Dermatology Medical Center\u2014University of Freiburg Freiburg Germany"},{"name":"Faculty of Biology University of Freiburg Freiburg Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Stefanie","family":"Kunz","sequence":"additional","affiliation":[{"name":"Allergy Research Group Department of Dermatology Medical Center\u2014University of Freiburg Freiburg Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Britta","family":"Dorn","sequence":"additional","affiliation":[{"name":"Allergy Research Group Department of Dermatology Medical Center\u2014University of Freiburg Freiburg Germany"},{"name":"Department of Dermatology and Allergology Justus Liebig University Giessen University Medical Center Giessen (UKGM) Giessen Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Axel","family":"Roers","sequence":"additional","affiliation":[{"name":"Institute of Immunology Medical Faculty Carl Gustav Carus Technische Universit\u00e4t Dresden Dresden Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Stefan F.","family":"Martin","sequence":"additional","affiliation":[{"name":"Allergy Research Group Department of Dermatology Medical Center\u2014University of Freiburg Freiburg Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Thilo","family":"Jakob","sequence":"additional","affiliation":[{"name":"Allergy Research Group Department of Dermatology Medical Center\u2014University of Freiburg Freiburg Germany"},{"name":"Department of Dermatology and Allergology Justus Liebig University Giessen University Medical Center Giessen (UKGM) Giessen Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2017,3,2]]},"reference":[{"key":"e_1_2_3_2_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1398-9995.2009.02082.x"},{"key":"e_1_2_3_3_1","doi-asserted-by":"publisher","DOI":"10.1038\/nri3150"},{"key":"e_1_2_3_4_1","doi-asserted-by":"publisher","DOI":"10.1084\/jem.182.1.99"},{"key":"e_1_2_3_5_1","doi-asserted-by":"publisher","DOI":"10.4049\/jimmunol.0900185"},{"key":"e_1_2_3_6_1","doi-asserted-by":"publisher","DOI":"10.1084\/jem.20041789"},{"key":"e_1_2_3_7_1","doi-asserted-by":"publisher","DOI":"10.1038\/ni.1649"},{"key":"e_1_2_3_8_1","doi-asserted-by":"publisher","DOI":"10.1146\/annurev-immunol-032712-095954"},{"key":"e_1_2_3_9_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jaci.2010.05.022"},{"key":"e_1_2_3_10_1","doi-asserted-by":"publisher","DOI":"10.1371\/journal.ppat.1002173"}],"container-title":["Experimental Dermatology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1111%2Fexd.13237","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1111%2Fexd.13237","content-type":"unspecified","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/exd.13237","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,9,23]],"date-time":"2023-09-23T15:10:47Z","timestamp":1695481847000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1111\/exd.13237"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2017,3,2]]},"references-count":9,"journal-issue":{"issue":"5","published-print":{"date-parts":[[2017,5]]}},"alternative-id":["10.1111\/exd.13237"],"URL":"https:\/\/doi.org\/10.1111\/exd.13237","archive":["Portico"],"relation":{},"ISSN":["0906-6705","1600-0625"],"issn-type":[{"value":"0906-6705","type":"print"},{"value":"1600-0625","type":"electronic"}],"subject":[],"published":{"date-parts":[[2017,3,2]]}}}