{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,8]],"date-time":"2026-07-08T04:35:53Z","timestamp":1783485353690,"version":"3.55.0"},"reference-count":9,"publisher":"Wiley","issue":"6","license":[{"start":{"date-parts":[[2017,2,14]],"date-time":"2017-02-14T00:00:00Z","timestamp":1487030400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Experimental Dermatology"],"published-print":{"date-parts":[[2017,6]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>The hair follicle (<jats:styled-content style=\"fixed-case\">HF<\/jats:styled-content>) epithelium can present self\u2010antigens to cognate <jats:styled-content style=\"fixed-case\">CD<\/jats:styled-content>8+ T cells. These cells express periodically during the hair cycle arising or age\u2010related immunogenic proteins including <jats:styled-content style=\"fixed-case\">HF<\/jats:styled-content>\u2010specific neo\u2010antigens. We propose that <jats:styled-content style=\"fixed-case\">IFN<\/jats:styled-content>\u2010gamma derived from the respective antigen\u2010specific T cells spotting the particular self\u2010peptides may thereby significantly induce and alter self\u2010antigen presentation (\u201cinduced\u2010self\u201d). This induction, at first, may silence T cells, including neo\u2010epitope\u2010specific T cells. As the thymus cannot significantly recapitulate neo\u2010epitopes evolving in the periphery, we propose that peripheral tissue\u2010specific induction of <jats:styled-content style=\"fixed-case\">MHC<\/jats:styled-content> molecules presenting exactly these neo\u2010epitopes by self\u2010<jats:styled-content style=\"fixed-case\">MHC<\/jats:styled-content>\/peptide\u2010reactive <jats:styled-content style=\"fixed-case\">CD<\/jats:styled-content>8+ T cells is a key element of self\u2010tolerance. Subsequently, however, the local perpetuation and modification of the same crosstalk in the context of <jats:styled-content style=\"fixed-case\">HF<\/jats:styled-content> immune privilege collapse can invite <jats:styled-content style=\"fixed-case\">HF<\/jats:styled-content> immunopathology, as typically seen in alopecia areata. This concept may essentially complement thymus\u2010based regulation models of self\/non\u2010self\u2010discrimination beyond \u201cmissing\u2010self\u201d to the fine\u2010tuned \u201cinduced\u2010self\u201d to ensure peripheral needs to maintain self\u2010tolerance in the case of \u201cdanger\u201d and any \u201calteration of self\u201d.<\/jats:p>","DOI":"10.1111\/exd.13238","type":"journal-article","created":{"date-parts":[[2016,10,13]],"date-time":"2016-10-13T04:42:16Z","timestamp":1476333736000},"page":"529-531","source":"Crossref","is-referenced-by-count":10,"title":["T\u2010cell \u201cinduced\u2010self\u201d <scp>MHC<\/scp> class I\/peptide complexes may enable \u201cde novo\u201d tolerance induction to neo\u2010antigens occurring outside of the thymus"],"prefix":"10.1111","volume":"26","author":[{"given":"Thilo","family":"Oelert","sequence":"first","affiliation":[{"name":"Independent Research HD (IRHD)  Heidelberg Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Amos","family":"Gilhar","sequence":"additional","affiliation":[{"name":"Technion\u2014Israel Institute of Technology  Haifa Israel"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ralf","family":"Paus","sequence":"additional","affiliation":[{"name":"Centre for Dermatology Research University of Manchester  Manchester UK"},{"name":"Department of Dermatology University of M\u00fcnster  M\u00fcnster Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2017,2,14]]},"reference":[{"key":"e_1_2_8_2_1","doi-asserted-by":"publisher","DOI":"10.1038\/172603a0"},{"key":"e_1_2_8_3_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.it.2004.09.014"},{"key":"e_1_2_8_4_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.clinbiochem.2015.05.019"},{"key":"e_1_2_8_5_1","first-page":"346","volume":"3","author":"Clevers H.","year":"2014","journal-title":"Science"},{"key":"e_1_2_8_6_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.immuni.2014.10.021"},{"key":"e_1_2_8_7_1","doi-asserted-by":"publisher","DOI":"10.1172\/JCI72932"},{"key":"e_1_2_8_8_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMra1103442"},{"key":"e_1_2_8_9_1","doi-asserted-by":"publisher","DOI":"10.1002\/eji.200324195"},{"key":"e_1_2_8_10_1","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.1115980109"}],"container-title":["Experimental Dermatology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1111%2Fexd.13238","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1111%2Fexd.13238","content-type":"unspecified","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/exd.13238","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,9,12]],"date-time":"2023-09-12T00:11:10Z","timestamp":1694477470000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1111\/exd.13238"}},"subtitle":["Lessons from the hair follicle"],"short-title":[],"issued":{"date-parts":[[2017,2,14]]},"references-count":9,"journal-issue":{"issue":"6","published-print":{"date-parts":[[2017,6]]}},"alternative-id":["10.1111\/exd.13238"],"URL":"https:\/\/doi.org\/10.1111\/exd.13238","archive":["Portico"],"relation":{},"ISSN":["0906-6705","1600-0625"],"issn-type":[{"value":"0906-6705","type":"print"},{"value":"1600-0625","type":"electronic"}],"subject":[],"published":{"date-parts":[[2017,2,14]]}}}