{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,13]],"date-time":"2026-07-13T14:11:42Z","timestamp":1783951902632,"version":"3.55.0"},"reference-count":17,"publisher":"Wiley","issue":"8","license":[{"start":{"date-parts":[[2017,3,23]],"date-time":"2017-03-23T00:00:00Z","timestamp":1490227200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/501100003725","name":"National Research Foundation of Korea","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100003725","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100003621","name":"Ministry of Science, ICT and Future Planning","doi-asserted-by":"publisher","award":["2014M3C9A2064536"],"award-info":[{"award-number":["2014M3C9A2064536"]}],"id":[{"id":"10.13039\/501100003621","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Experimental Dermatology"],"published-print":{"date-parts":[[2017,8]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>Exposure of the skin to ultraviolet (<jats:styled-content style=\"fixed-case\">UV<\/jats:styled-content>) irradiation causes various consequences such as inflammation and photoageing. Galanin is an active neuropeptide expressed widely in the central nervous system and peripheral tissues including the skin. Galanin promotes or inhibits inflammation in a context\u2010dependent manner, but its role in <jats:styled-content style=\"fixed-case\">UV<\/jats:styled-content> irradiation\u2010induced responses in human skin was still unknown. <jats:styled-content style=\"fixed-case\">UV<\/jats:styled-content> irradiation induced a substantial expression of galanin in primary epidermal keratinocytes in vitro and in human epidermis in vivo. Galanin knock\u2010down by si<jats:styled-content style=\"fixed-case\">RNA<\/jats:styled-content> transfection markedly inhibited <jats:styled-content style=\"fixed-case\">UV<\/jats:styled-content> irradiation\u2010induced expression of matrix metalloproteinase (<jats:styled-content style=\"fixed-case\">MMP<\/jats:styled-content>)\u20101, interleukin (<jats:styled-content style=\"fixed-case\">IL<\/jats:styled-content>)\u20101\u03b2, <jats:styled-content style=\"fixed-case\">IL<\/jats:styled-content>\u20106 and cyclooxygenase (<jats:styled-content style=\"fixed-case\">COX<\/jats:styled-content>)\u20102. Moreover, si<jats:styled-content style=\"fixed-case\">RNA<\/jats:styled-content>\u2010mediated knock\u2010down of <jats:styled-content style=\"fixed-case\">GAL<\/jats:styled-content><jats:sub>2<\/jats:sub>, a principal galanin receptor in the skin, led to a considerable decrease in these mediators in keratinocytes. Collectively, our findings suggest that galanin is an important messenger between the neuroendocrine system and <jats:styled-content style=\"fixed-case\">UV<\/jats:styled-content> irradiation\u2010damaged skin.<\/jats:p>","DOI":"10.1111\/exd.13268","type":"journal-article","created":{"date-parts":[[2016,12,11]],"date-time":"2016-12-11T08:07:08Z","timestamp":1481443628000},"page":"744-747","source":"Crossref","is-referenced-by-count":6,"title":["Galanin contributes to ultraviolet irradiation\u2010induced inflammation in human skin"],"prefix":"10.1111","volume":"26","author":[{"given":"Min Jung","family":"Lee","sequence":"first","affiliation":[{"name":"Department of Dermatology Seoul National University College of Medicine  Seoul Korea"},{"name":"Laboratory of Cutaneous Aging Research Biomedical Research Institute Seoul National University Hospital  Seoul Korea"},{"name":"Institute of Human\u2010Environment Interface Biology Medical Research Center Seoul National University  Seoul Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jang\u2010Hee","family":"Oh","sequence":"additional","affiliation":[{"name":"Department of Dermatology Seoul National University College of Medicine  Seoul Korea"},{"name":"Laboratory of Cutaneous Aging Research Biomedical Research Institute Seoul National University Hospital  Seoul Korea"},{"name":"Institute of Human\u2010Environment Interface Biology Medical Research Center Seoul National University  Seoul Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Chi\u2010Hyun","family":"Park","sequence":"additional","affiliation":[{"name":"Department of Dermatology Seoul National University College of Medicine  Seoul Korea"},{"name":"Laboratory of Cutaneous Aging Research Biomedical Research Institute Seoul National University Hospital  Seoul Korea"},{"name":"Institute of Human\u2010Environment Interface Biology Medical Research Center Seoul National University  Seoul Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kyu Han","family":"Kim","sequence":"additional","affiliation":[{"name":"Department of Dermatology Seoul National University College of Medicine  Seoul Korea"},{"name":"Laboratory of Cutaneous Aging Research Biomedical Research Institute Seoul National University Hospital  Seoul Korea"},{"name":"Institute of Human\u2010Environment Interface Biology Medical Research Center Seoul National University  Seoul Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Dong Hun","family":"Lee","sequence":"additional","affiliation":[{"name":"Department of Dermatology Seoul National University College of Medicine  Seoul Korea"},{"name":"Laboratory of Cutaneous Aging Research Biomedical Research Institute Seoul National University Hospital  Seoul Korea"},{"name":"Institute of Human\u2010Environment Interface Biology Medical Research Center Seoul National University  Seoul Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jin Ho","family":"Chung","sequence":"additional","affiliation":[{"name":"Department of Dermatology Seoul National University College of Medicine  Seoul Korea"},{"name":"Laboratory of Cutaneous Aging Research Biomedical Research Institute Seoul National University Hospital  Seoul Korea"},{"name":"Institute of Human\u2010Environment Interface Biology Medical Research Center Seoul National University  Seoul Korea"},{"name":"Institute on Aging Seoul National University  Seoul Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2017,3,23]]},"reference":[{"key":"e_1_2_2_2_1","doi-asserted-by":"publisher","DOI":"10.1111\/exd.13084"},{"key":"e_1_2_2_3_1","doi-asserted-by":"publisher","DOI":"10.1111\/exd.13085"},{"key":"e_1_2_2_4_1","doi-asserted-by":"publisher","DOI":"10.1111\/exd.12637"},{"key":"e_1_2_2_5_1","doi-asserted-by":"publisher","DOI":"10.1038\/jidsymp.2009.8"},{"key":"e_1_2_2_6_1","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0061696"},{"key":"e_1_2_2_7_1","doi-asserted-by":"publisher","DOI":"10.1111\/exd.12735"},{"key":"e_1_2_2_8_1","doi-asserted-by":"publisher","DOI":"10.1124\/pr.112.006536"},{"key":"e_1_2_2_9_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.pharmthera.2007.05.009"},{"key":"e_1_2_2_10_1","first-page":"122","volume":"2004","author":"Kofler B.","journal-title":"J. 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