{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,23]],"date-time":"2026-09-23T04:11:05Z","timestamp":1790136665761,"version":"4.0.1"},"reference-count":13,"publisher":"Wiley","issue":"9","license":[{"start":{"date-parts":[[2017,4,11]],"date-time":"2017-04-11T00:00:00Z","timestamp":1491868800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Experimental Dermatology"],"published-print":{"date-parts":[[2017,9]]},"abstract":"Abstract<\/jats:title>UVA<\/jats:styled-content>\u20101 is a known promotor of skin ageing. Cytokines like IL<\/jats:styled-content>\u20101\u03b1, Il\u20101\u03b2 or TNF<\/jats:styled-content>\u2010\u03b1, VEGF<\/jats:styled-content> and IL<\/jats:styled-content>\u20106 orchestrate UV<\/jats:styled-content> effects, and IL<\/jats:styled-content>\u20106 is furthermore an effector of UVA<\/jats:styled-content>\u2010induced photoageing. We investigated how fractionated UVA<\/jats:styled-content>\u20101 doses influence the cytokine milieu and especially the IL<\/jats:styled-content>\u20106 levels in the skin in vivo. In a study with 35 participants, we exposed previously unirradiated human skin to three UVA<\/jats:styled-content>\u20101 irradiation regimes. Cytokine levels in interstitial skin fluid were measured up to 48\u00a0hours postexposure and compared to unirradiated control skin fluid. Our results show that IL<\/jats:styled-content>\u20106 levels increased significantly after UVA<\/jats:styled-content>\u20101 exposure at selected time points. The other candidates IL<\/jats:styled-content>\u20101\u03b1, Il\u20101\u03b2 or TNF<\/jats:styled-content>\u2010\u03b1 and VEGF<\/jats:styled-content> show no significant response after UVA<\/jats:styled-content>\u20101 exposure in vivo. UVA<\/jats:styled-content>\u20101 thus raises selectively IL<\/jats:styled-content>\u20106 levels in vivo, a fact that underlines its role in photoageing and has potential implications for its modulatory effect on photoageing pathology.<\/jats:p>","DOI":"10.1111\/exd.13286","type":"journal-article","created":{"date-parts":[[2017,1,17]],"date-time":"2017-01-17T18:12:31Z","timestamp":1484676751000},"page":"830-832","source":"Crossref","is-referenced-by-count":38,"title":["UVA<\/scp>\u20101 exposure in vivo leads to an IL<\/scp>\u20106 surge within the skin"],"prefix":"10.1111","volume":"26","author":[{"given":"Lars Alexander","family":"Schneider","sequence":"first","affiliation":[{"name":"University Department of Dermatology and Allergology Ulm Germany"},{"name":"Department of Dermatology and Allergology Helios Klinik Rottweil Rottweil Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Katharina","family":"Raizner","sequence":"additional","affiliation":[{"name":"University Department of Dermatology and Allergology Ulm Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Meinhard","family":"Wlaschek","sequence":"additional","affiliation":[{"name":"University Department of Dermatology and Allergology Ulm Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Peter","family":"Brenneisen","sequence":"additional","affiliation":[{"name":"Heinrich\u2010Heine\u2010University Medical Faculty Biochemistry & Molecular Biology I Duesseldorf Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kerstin","family":"Geth\u00f6ffer","sequence":"additional","affiliation":[{"name":"University Department of Dermatology and Allergology Ulm Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Karin","family":"Scharffetter\u2010Kochanek","sequence":"additional","affiliation":[{"name":"University Department of Dermatology and Allergology Ulm Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2017,4,11]]},"reference":[{"key":"e_1_2_2_2_1","doi-asserted-by":"publisher","DOI":"10.1038\/jid.2014.173"},{"key":"e_1_2_2_3_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1751-1097.1994.tb02982.x"},{"key":"e_1_2_2_4_1","doi-asserted-by":"publisher","DOI":"10.1034\/j.1600-0781.2000.160603.x"},{"key":"e_1_2_2_5_1","doi-asserted-by":"publisher","DOI":"10.1034\/j.1600-0781.2000.160602.x"},{"key":"e_1_2_2_6_1","doi-asserted-by":"publisher","DOI":"10.1007\/PL00000265"},{"key":"e_1_2_2_7_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0014-5793(97)00919-8"},{"key":"e_1_2_2_8_1","doi-asserted-by":"publisher","DOI":"10.1111\/1523-1747.ep12363644"},{"key":"e_1_2_2_9_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1610-0387.2007.06281.x"},{"key":"e_1_2_2_10_1","doi-asserted-by":"publisher","DOI":"10.3109\/1547691X.2012.707700"},{"key":"e_1_2_2_11_1","doi-asserted-by":"publisher","DOI":"10.1038\/sj.jid.5602962"},{"key":"e_1_2_2_12_1","doi-asserted-by":"publisher","DOI":"10.1038\/jid.2011.283"},{"key":"e_1_2_2_13_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0014-5793(01)03169-6"},{"key":"e_1_2_2_14_1","doi-asserted-by":"publisher","DOI":"10.1039\/b516702g"}],"container-title":["Experimental Dermatology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1111%2Fexd.13286","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/exd.13286","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,9,24]],"date-time":"2023-09-24T06:51:55Z","timestamp":1695538315000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1111\/exd.13286"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2017,4,11]]},"references-count":13,"journal-issue":{"issue":"9","published-print":{"date-parts":[[2017,9]]}},"alternative-id":["10.1111\/exd.13286"],"URL":"https:\/\/doi.org\/10.1111\/exd.13286","archive":["Portico"],"relation":{},"ISSN":["0906-6705","1600-0625"],"issn-type":[{"value":"0906-6705","type":"print"},{"value":"1600-0625","type":"electronic"}],"subject":[],"published":{"date-parts":[[2017,4,11]]}}}