{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,26]],"date-time":"2026-09-26T10:43:35Z","timestamp":1790419415114,"version":"4.1.0"},"reference-count":225,"publisher":"Wiley","issue":"9","license":[{"start":{"date-parts":[[2017,4,2]],"date-time":"2017-04-02T00:00:00Z","timestamp":1491091200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Experimental Dermatology"],"published-print":{"date-parts":[[2017,9]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>Mast cells (<jats:styled-content style=\"fixed-case\">MC<\/jats:styled-content>) are hemotopoietically derived tissue immune cells that are ubiquitous in the body, including neuroendocrine organs such as the hypothalamus, pineal, pituitary, ovaries, pancreas and uterus where their action is not well understood. Mast cells have historically been associated with allergies because of their rich content of histamine and tryptase, but more recently with regulation of immunity and inflammation due to their synthesis and release of numerous cytokines and chemokines. Mast cells are located perivascularly and express numerous receptors for diverse ligands such as allergens, pathogens, neurotransmitters, neuropeptides and hormones including acetylcholine, calcitonin gene\u2010related peptide (<jats:styled-content style=\"fixed-case\">CGRP<\/jats:styled-content>), corticosteroids, corticotropin\u2010releasing hormone (<jats:styled-content style=\"fixed-case\">CRH<\/jats:styled-content>), \u03b2\u2010endorphin, epinephrine, 17\u03b2\u2010oestradiol, gonadotrophins, hemokinin\u2010A (<jats:styled-content style=\"fixed-case\">HKA<\/jats:styled-content>), leptin, melatonin, neurotensin (<jats:styled-content style=\"fixed-case\">NT<\/jats:styled-content>), parathyroid hormone (<jats:styled-content style=\"fixed-case\">PTH<\/jats:styled-content>), substance P (<jats:styled-content style=\"fixed-case\">SP<\/jats:styled-content>) and vasoactive intestinal peptide (<jats:styled-content style=\"fixed-case\">VIP<\/jats:styled-content>). Moreover,<jats:styled-content style=\"fixed-case\">MC<\/jats:styled-content>can synthesize and release most of their neurohormonal triggers, including adrenocorticotropin hormone (<jats:styled-content style=\"fixed-case\">ACTH<\/jats:styled-content>),<jats:styled-content style=\"fixed-case\">CRH<\/jats:styled-content>, endorphins,<jats:styled-content style=\"fixed-case\">HKA<\/jats:styled-content>, leptin, melatonin,<jats:styled-content style=\"fixed-case\">NT<\/jats:styled-content>,<jats:styled-content style=\"fixed-case\">SP<\/jats:styled-content>and<jats:styled-content style=\"fixed-case\">VIP<\/jats:styled-content>. Animal experiments have shown that diencephalic<jats:styled-content style=\"fixed-case\">MC<\/jats:styled-content>increase in number during courting in doves, while stimulation of brain and nasal<jats:styled-content style=\"fixed-case\">MC<\/jats:styled-content>leads to activation of the hypothalamic\u2010pituitary\u2010adrenal (<jats:styled-content style=\"fixed-case\">HPA<\/jats:styled-content>) axis. Recent evidence indicates that<jats:styled-content style=\"fixed-case\">MC<\/jats:styled-content>reactivity exhibits diurnal variations, and it is interesting that melatonin appears to regulate<jats:styled-content style=\"fixed-case\">MC<\/jats:styled-content>secretion. However, the way<jats:styled-content style=\"fixed-case\">MC<\/jats:styled-content>change their phenotype or secrete specific molecules selectively at different pathophysiological settings still remains unknown. Mast cells developed over 500\u00a0million years ago and may have served as the original prototype neuroimmunoendocrine cell and then evolved into a master regulator of such interactions, especially as most of the known diseases involve neuroinflammation that worsens with stress.<\/jats:p>","DOI":"10.1111\/exd.13288","type":"journal-article","created":{"date-parts":[[2017,1,17]],"date-time":"2017-01-17T18:17:08Z","timestamp":1484677028000},"page":"751-759","source":"Crossref","is-referenced-by-count":101,"title":["Neuroendocrinology of mast cells: Challenges and controversies"],"prefix":"10.1111","volume":"26","author":[{"given":"Theoharis C.","family":"Theoharides","sequence":"first","affiliation":[{"name":"Molecular Immunopharmacology and Drug Discovery Laboratory Department of Integrative Physiology and Pathobiology Tufts University School of Medicine Boston MA USA"},{"name":"Sackler School of Graduate Biomedical Sciences Program in Pharmacology and Experimental Therapeutics Tufts University Boston MA USA"},{"name":"Department of Internal Medicine Tufts University School of Medicine and Tufts Medical Center Boston MA USA"},{"name":"Department of Psychiatry Tufts University School of Medicine and Tufts Medical Center Boston MA USA"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2017,4,2]]},"reference":[{"key":"e_1_2_13_2_1","doi-asserted-by":"publisher","DOI":"10.1007\/s11154-016-9369-9"},{"key":"e_1_2_13_3_1","first-page":"339","volume":"30","author":"Caraffa A.","year":"2016","journal-title":"J. Biol. Regul. Homeost. Agents"},{"key":"e_1_2_13_4_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.it.2005.10.002"},{"key":"e_1_2_13_5_1","doi-asserted-by":"publisher","DOI":"10.1210\/er.2012-1092"},{"key":"e_1_2_13_6_1","doi-asserted-by":"publisher","DOI":"10.1126\/science.271.5250.818"},{"key":"e_1_2_13_7_1","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.0504197102"},{"key":"e_1_2_13_8_1","doi-asserted-by":"publisher","DOI":"10.1038\/ni.2109"},{"key":"e_1_2_13_9_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0301-472X(00)00161-2"},{"key":"e_1_2_13_10_1","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.91.9.3739"},{"key":"e_1_2_13_11_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.immuni.2012.07.003"},{"key":"e_1_2_13_12_1","doi-asserted-by":"publisher","DOI":"10.1038\/nri3690"},{"key":"e_1_2_13_13_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jaci.2016.04.009"},{"key":"e_1_2_13_14_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jaci.2009.10.054"},{"key":"e_1_2_13_15_1","doi-asserted-by":"publisher","DOI":"10.3389\/fimmu.2012.00238"},{"key":"e_1_2_13_16_1","doi-asserted-by":"publisher","DOI":"10.1038\/nri2782"},{"key":"e_1_2_13_17_1","doi-asserted-by":"publisher","DOI":"10.3389\/fimmu.2012.00146"},{"key":"e_1_2_13_18_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00281-016-0565-1"},{"key":"e_1_2_13_19_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa1500611"},{"key":"e_1_2_13_20_1","doi-asserted-by":"publisher","DOI":"10.4049\/jimmunol.171.9.4830"},{"key":"e_1_2_13_21_1","doi-asserted-by":"publisher","DOI":"10.1111\/all.12309"},{"key":"e_1_2_13_22_1","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.1000803107"},{"key":"e_1_2_13_23_1","doi-asserted-by":"publisher","DOI":"10.4049\/jimmunol.1003383"},{"key":"e_1_2_13_24_1","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0003331"},{"key":"e_1_2_13_25_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.clinthera.2016.03.036"},{"key":"e_1_2_13_26_1","doi-asserted-by":"publisher","DOI":"10.1002\/eji.201444546"},{"key":"e_1_2_13_27_1","doi-asserted-by":"publisher","DOI":"10.1038\/nri1782"},{"key":"e_1_2_13_28_1","doi-asserted-by":"publisher","DOI":"10.1038\/sj.bjp.0703672"},{"issue":"4","key":"e_1_2_13_29_1","first-page":"L387","volume":"264","author":"Inase N.","year":"1993","journal-title":"Am. J. Physiol."},{"key":"e_1_2_13_30_1","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0015071"},{"key":"e_1_2_13_31_1","doi-asserted-by":"publisher","DOI":"10.1016\/0006-2952(92)90183-J"},{"key":"e_1_2_13_32_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1600-065X.2007.00512.x"},{"key":"e_1_2_13_33_1","doi-asserted-by":"publisher","DOI":"10.1021\/jf9016288"},{"key":"e_1_2_13_34_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.bbadis.2010.12.014"},{"key":"e_1_2_13_35_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMra1409760"},{"key":"e_1_2_13_36_1","doi-asserted-by":"publisher","DOI":"10.1172\/JCI85538"},{"key":"e_1_2_13_37_1","doi-asserted-by":"publisher","DOI":"10.1126\/science.684435"},{"key":"e_1_2_13_38_1","doi-asserted-by":"publisher","DOI":"10.1038\/297229a0"},{"key":"e_1_2_13_39_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1600-065X.2007.00519.x"},{"key":"e_1_2_13_40_1","doi-asserted-by":"crossref","first-page":"2654","DOI":"10.1182\/blood.V89.8.2654","volume":"89","author":"Gagari E.","year":"1997","journal-title":"Blood"},{"key":"e_1_2_13_41_1","doi-asserted-by":"publisher","DOI":"10.4049\/jimmunol.174.12.7665"},{"key":"e_1_2_13_42_1","doi-asserted-by":"publisher","DOI":"10.4049\/jimmunol.172.2.1227"},{"key":"e_1_2_13_43_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1460-9568.2005.04429.x"},{"key":"e_1_2_13_44_1","doi-asserted-by":"publisher","DOI":"10.1038\/ncomms7174"},{"key":"e_1_2_13_45_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.clinthera.2016.02.030"},{"key":"e_1_2_13_46_1","doi-asserted-by":"publisher","DOI":"10.1093\/intimm\/dxp118"},{"key":"e_1_2_13_47_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0161-5890(02)00088-3"},{"key":"e_1_2_13_48_1","doi-asserted-by":"publisher","DOI":"10.2174\/138161211798357836"},{"key":"e_1_2_13_49_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jaci.2013.04.048"},{"key":"e_1_2_13_50_1","first-page":"66","volume":"6","author":"ito\u2010Martin A.","year":"2015","journal-title":"Front Immunol."},{"key":"e_1_2_13_51_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.clinthera.2014.05.005"},{"key":"e_1_2_13_52_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.brainres.2014.09.070"},{"key":"e_1_2_13_53_1","doi-asserted-by":"publisher","DOI":"10.1038\/ajg.2012.61"},{"key":"e_1_2_13_54_1","doi-asserted-by":"publisher","DOI":"10.1111\/exd.13008"},{"key":"e_1_2_13_55_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jneuroim.2003.10.041"},{"key":"e_1_2_13_56_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2133.1994.tb02900.x"},{"key":"e_1_2_13_57_1","first-page":"7","volume":"12","author":"Katsarou\u2010Katsari A.","year":"1999","journal-title":"Int. J. Immunopathol. Pharmacol."},{"key":"e_1_2_13_58_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.clinthera.2014.05.006"},{"key":"e_1_2_13_59_1","first-page":"238","volume":"42","author":"Graham D. T.","year":"1953","journal-title":"J. Lab. Clin. Med."},{"key":"e_1_2_13_60_1","doi-asserted-by":"publisher","DOI":"10.1159\/000084752"},{"key":"e_1_2_13_61_1","doi-asserted-by":"publisher","DOI":"10.1111\/ced.12582"},{"key":"e_1_2_13_62_1","doi-asserted-by":"publisher","DOI":"10.1007\/s11154-016-9367-y"},{"key":"e_1_2_13_63_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jaip.2013.09.004"},{"key":"e_1_2_13_64_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2230.2008.03043.x"},{"key":"e_1_2_13_65_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2133.2008.08958.x"},{"key":"e_1_2_13_66_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1600-0625.2006.00382.x"},{"key":"e_1_2_13_67_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jaci.2014.05.023"},{"key":"e_1_2_13_68_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.anai.2013.07.018"},{"key":"e_1_2_13_69_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jneuroim.2003.10.041"},{"key":"e_1_2_13_70_1","doi-asserted-by":"crossref","first-page":"296","DOI":"10.2340\/000155557293295","volume":"73","author":"Sugiura H.","year":"1993","journal-title":"Acta Derm. Venereol. (Stockh)"},{"key":"e_1_2_13_71_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jaci.2011.01.053"},{"key":"e_1_2_13_72_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jaci.2011.01.054"},{"key":"e_1_2_13_73_1","doi-asserted-by":"publisher","DOI":"10.1002\/(SICI)1096-9896(199610)180:2<200::AID-PATH632>3.0.CO;2-Z"},{"key":"e_1_2_13_74_1","doi-asserted-by":"publisher","DOI":"10.1046\/j.1365-4362.2001.01262.x"},{"key":"e_1_2_13_75_1","doi-asserted-by":"publisher","DOI":"10.1159\/000288690"},{"key":"e_1_2_13_76_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1398-9995.2004.00628.x"},{"key":"e_1_2_13_77_1","doi-asserted-by":"publisher","DOI":"10.1007\/s004030050189"},{"key":"e_1_2_13_78_1","first-page":"115","volume":"144","author":"Sugiura H.","year":"1989","journal-title":"Acta. Derm. Venereol. Suppl. (Stockh)"},{"key":"e_1_2_13_79_1","doi-asserted-by":"publisher","DOI":"10.1111\/pai.12518"},{"key":"e_1_2_13_80_1","doi-asserted-by":"publisher","DOI":"10.1001\/archpedi.160.8.825"},{"key":"e_1_2_13_81_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jneuroim.2009.09.015"},{"key":"e_1_2_13_82_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jaci.2012.10.041"},{"key":"e_1_2_13_83_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jpsychores.2014.06.006"},{"key":"e_1_2_13_84_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.bbi.2015.02.001"},{"key":"e_1_2_13_85_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.bbr.2013.12.008"},{"key":"e_1_2_13_86_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1600-0625.1998.tb00326.x"},{"key":"e_1_2_13_87_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.tips.2004.09.007"},{"key":"e_1_2_13_88_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJM199505183322008"},{"key":"e_1_2_13_89_1","doi-asserted-by":"publisher","DOI":"10.1096\/fj.00-0850rev"},{"key":"e_1_2_13_90_1","doi-asserted-by":"publisher","DOI":"10.2741\/1966"},{"key":"e_1_2_13_91_1","doi-asserted-by":"publisher","DOI":"10.1152\/physrev.2000.80.3.979"},{"key":"e_1_2_13_92_1","doi-asserted-by":"publisher","DOI":"10.1210\/er.21.5.457"},{"key":"e_1_2_13_93_1","doi-asserted-by":"publisher","DOI":"10.1046\/j.1523-1747.2002.19617.x"},{"key":"e_1_2_13_94_1","doi-asserted-by":"publisher","DOI":"10.1210\/jc.83.3.1020"},{"key":"e_1_2_13_95_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0165-5728(96)00178-6"},{"key":"e_1_2_13_96_1","doi-asserted-by":"publisher","DOI":"10.1210\/en.2003-0805"},{"key":"e_1_2_13_97_1","doi-asserted-by":"publisher","DOI":"10.1007\/BF02136238"},{"key":"e_1_2_13_98_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0006-8993(99)01855-7"},{"key":"e_1_2_13_99_1","doi-asserted-by":"publisher","DOI":"10.1096\/fasebj.12.03.287"},{"key":"e_1_2_13_100_1","doi-asserted-by":"publisher","DOI":"10.1038\/sj.jid.5700153"},{"key":"e_1_2_13_101_1","doi-asserted-by":"publisher","DOI":"10.1038\/jid.2009.387"},{"key":"e_1_2_13_102_1","doi-asserted-by":"publisher","DOI":"10.1096\/fj.04-1968fje"},{"key":"e_1_2_13_103_1","doi-asserted-by":"publisher","DOI":"10.1159\/000069516"},{"key":"e_1_2_13_104_1","doi-asserted-by":"publisher","DOI":"10.1210\/endo.139.1.5660"},{"key":"e_1_2_13_105_1","doi-asserted-by":"publisher","DOI":"10.1210\/jc.2003-030377"},{"key":"e_1_2_13_106_1","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.0602210103"},{"key":"e_1_2_13_107_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.juro.2006.04.026"},{"key":"e_1_2_13_108_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0006-8993(03)02975-5"},{"key":"e_1_2_13_109_1","doi-asserted-by":"publisher","DOI":"10.3109\/9780203008966-17"},{"key":"e_1_2_13_110_1","doi-asserted-by":"publisher","DOI":"10.1038\/sj.jid.5700104"},{"key":"e_1_2_13_111_1","doi-asserted-by":"publisher","DOI":"10.1084\/jem.194.1.71"},{"key":"e_1_2_13_112_1","doi-asserted-by":"publisher","DOI":"10.1007\/BF01674391"},{"key":"e_1_2_13_113_1","doi-asserted-by":"publisher","DOI":"10.1016\/S1081-1206(10)60717-X"},{"key":"e_1_2_13_114_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0024-3205(00)00899-7"},{"key":"e_1_2_13_115_1","doi-asserted-by":"publisher","DOI":"10.1210\/jc.77.6.1690"},{"key":"e_1_2_13_116_1","doi-asserted-by":"publisher","DOI":"10.1210\/endo-102-5-1637"},{"key":"e_1_2_13_117_1","doi-asserted-by":"publisher","DOI":"10.1007\/BF02142543"},{"key":"e_1_2_13_118_1","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.91.9.3675"},{"key":"e_1_2_13_119_1","first-page":"1","volume":"4","author":"Silver R.","year":"1991","journal-title":"J. Neuroendocrinol."},{"key":"e_1_2_13_120_1","doi-asserted-by":"publisher","DOI":"10.1016\/S1095-6433(98)00027-0"},{"key":"e_1_2_13_121_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.yhbeh.2003.09.001"},{"key":"e_1_2_13_122_1","doi-asserted-by":"crossref","first-page":"389","DOI":"10.1016\/S0022-3565(24)37801-2","volume":"287","author":"Rudolph M. I.","year":"1998","journal-title":"J. Pharmacol. Exp. Ther."},{"key":"e_1_2_13_123_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0167-0115(99)00054-3"},{"key":"e_1_2_13_124_1","doi-asserted-by":"publisher","DOI":"10.2353\/ajpath.2010.090941"},{"key":"e_1_2_13_125_1","doi-asserted-by":"publisher","DOI":"10.1309\/A7N5-08DQ-RHET-N57H"},{"key":"e_1_2_13_126_1","first-page":"99","volume":"17","author":"Bianco A. C.","year":"1983","journal-title":"Endocrinol. Exp."},{"key":"e_1_2_13_127_1","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0014794"},{"key":"e_1_2_13_128_1","doi-asserted-by":"publisher","DOI":"10.1016\/0006-2952(83)90567-1"},{"key":"e_1_2_13_129_1","first-page":"501","volume":"36","author":"Catini C.","year":"1992","journal-title":"Eur. J. Histochem."},{"key":"e_1_2_13_130_1","doi-asserted-by":"publisher","DOI":"10.1111\/all.12596"},{"key":"e_1_2_13_131_1","doi-asserted-by":"publisher","DOI":"10.1242\/jeb.00786"},{"key":"e_1_2_13_132_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.2047-2927.2014.00207.x"},{"key":"e_1_2_13_133_1","doi-asserted-by":"publisher","DOI":"10.1007\/BF01011855"},{"key":"e_1_2_13_134_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1748-1716.1976.tb00236.x"},{"key":"e_1_2_13_135_1","doi-asserted-by":"publisher","DOI":"10.1021\/bi00368a068"},{"key":"e_1_2_13_136_1","doi-asserted-by":"publisher","DOI":"10.1016\/0306-4522(90)90233-T"},{"key":"e_1_2_13_137_1","doi-asserted-by":"publisher","DOI":"10.1038\/273473a0"},{"key":"e_1_2_13_138_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0091-6749(97)70280-X"},{"key":"e_1_2_13_139_1","doi-asserted-by":"publisher","DOI":"10.1159\/000236122"},{"key":"e_1_2_13_140_1","doi-asserted-by":"publisher","DOI":"10.1007\/BF01993114"},{"key":"e_1_2_13_141_1","doi-asserted-by":"publisher","DOI":"10.2174\/1568010053586309"},{"key":"e_1_2_13_142_1","doi-asserted-by":"publisher","DOI":"10.1038\/nature14022"},{"key":"e_1_2_13_143_1","doi-asserted-by":"publisher","DOI":"10.1113\/jphysiol.1982.sp014347"},{"key":"e_1_2_13_144_1","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.1000803107"},{"key":"e_1_2_13_145_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jaci.2011.02.005"},{"key":"e_1_2_13_146_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0021-9258(19)66951-6"},{"key":"e_1_2_13_147_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0021-9258(19)66952-8"},{"key":"e_1_2_13_148_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2567.2007.02705.x"},{"key":"e_1_2_13_149_1","doi-asserted-by":"publisher","DOI":"10.1016\/0006-8993(77)90772-7"},{"key":"e_1_2_13_150_1","first-page":"929","volume":"46","author":"Tomioka M.","year":"1987","journal-title":"Fed. Proc."},{"key":"e_1_2_13_151_1","doi-asserted-by":"publisher","DOI":"10.1152\/physrev.00031.2013"},{"key":"e_1_2_13_152_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00403-007-0745-x"},{"key":"e_1_2_13_153_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00403-002-0378-z"},{"key":"e_1_2_13_154_1","doi-asserted-by":"publisher","DOI":"10.1097\/MED.0b013e3283419052"},{"key":"e_1_2_13_155_1","doi-asserted-by":"publisher","DOI":"10.1007\/s000110050325"},{"key":"e_1_2_13_156_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0162-3109(98)00064-2"},{"key":"e_1_2_13_157_1","doi-asserted-by":"publisher","DOI":"10.1113\/jphysiol.1982.sp014080"},{"key":"e_1_2_13_158_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1749-6632.1982.tb31591.x"},{"key":"e_1_2_13_159_1","doi-asserted-by":"publisher","DOI":"10.1159\/000234057"},{"key":"e_1_2_13_160_1","doi-asserted-by":"publisher","DOI":"10.1006\/brbi.1998.0541"},{"key":"e_1_2_13_161_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00011-011-0378-6"},{"key":"e_1_2_13_162_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jaci.2014.07.036"},{"key":"e_1_2_13_163_1","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0049767"},{"key":"e_1_2_13_164_1","doi-asserted-by":"publisher","DOI":"10.1186\/1742-2094-9-85"},{"key":"e_1_2_13_165_1","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0048934"},{"key":"e_1_2_13_166_1","doi-asserted-by":"publisher","DOI":"10.1111\/exd.12924"},{"key":"e_1_2_13_167_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jneuroim.2005.02.015"},{"key":"e_1_2_13_168_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.molimm.2006.09.030"},{"key":"e_1_2_13_169_1","doi-asserted-by":"publisher","DOI":"10.1289\/ehp.9378"},{"key":"e_1_2_13_170_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1749-6632.1998.tb09601.x"},{"key":"e_1_2_13_171_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0090-4295(96)00239-7"},{"key":"e_1_2_13_172_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1464-410X.1995.tb07303.x"},{"key":"e_1_2_13_173_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jaci.2014.11.003"},{"key":"e_1_2_13_174_1","doi-asserted-by":"publisher","DOI":"10.1136\/thorax.56.3.205"},{"key":"e_1_2_13_175_1","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0014409"},{"key":"e_1_2_13_176_1","first-page":"183","volume":"84","author":"Jaiswal K.","year":"1996","journal-title":"Acta Physiol. Hung."},{"key":"e_1_2_13_177_1","doi-asserted-by":"publisher","DOI":"10.1177\/039463200601900408"},{"key":"e_1_2_13_178_1","doi-asserted-by":"publisher","DOI":"10.1159\/000235289"},{"key":"e_1_2_13_179_1","doi-asserted-by":"publisher","DOI":"10.1111\/exd.12006"},{"key":"e_1_2_13_180_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1743-6109.2006.00397.x"},{"key":"e_1_2_13_181_1","doi-asserted-by":"publisher","DOI":"10.3109\/01485019108987633"},{"key":"e_1_2_13_182_1","doi-asserted-by":"publisher","DOI":"10.1159\/000235190"},{"key":"e_1_2_13_183_1","doi-asserted-by":"publisher","DOI":"10.1159\/000273475"},{"key":"e_1_2_13_184_1","doi-asserted-by":"publisher","DOI":"10.1080\/014850190944456"},{"key":"e_1_2_13_185_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1439-0531.2011.01897.x"},{"key":"e_1_2_13_186_1","doi-asserted-by":"publisher","DOI":"10.1038\/icb.2011.40"},{"key":"e_1_2_13_187_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ajog.2005.05.011"},{"key":"e_1_2_13_188_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0301-2115(00)00564-9"},{"key":"e_1_2_13_189_1","doi-asserted-by":"publisher","DOI":"10.1007\/BF01993113"},{"key":"e_1_2_13_190_1","doi-asserted-by":"publisher","DOI":"10.1159\/000135701"},{"key":"e_1_2_13_191_1","doi-asserted-by":"publisher","DOI":"10.1095\/biolreprod.107.066373"},{"key":"e_1_2_13_192_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ajog.2004.04.008"},{"key":"e_1_2_13_193_1","doi-asserted-by":"publisher","DOI":"10.1530\/rep.1.00018"},{"key":"e_1_2_13_194_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1600-0897.1999.tb00073.x"},{"key":"e_1_2_13_195_1","doi-asserted-by":"publisher","DOI":"10.1210\/en.2003-0063"},{"key":"e_1_2_13_196_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1600-0897.2004.00224.x"},{"key":"e_1_2_13_197_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1600-0897.1998.tb00420.x"},{"key":"e_1_2_13_198_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1600-0897.2005.00254.x"},{"key":"e_1_2_13_199_1","doi-asserted-by":"publisher","DOI":"10.1177\/1933719112438443"},{"key":"e_1_2_13_200_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1600-0897.2007.00502.x"},{"key":"e_1_2_13_201_1","doi-asserted-by":"publisher","DOI":"10.1177\/0394632016644447"},{"key":"e_1_2_13_202_1","doi-asserted-by":"publisher","DOI":"10.1038\/nm1601"},{"key":"e_1_2_13_203_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.tips.2011.05.005"},{"key":"e_1_2_13_204_1","doi-asserted-by":"publisher","DOI":"10.1146\/annurev-immunol-031210-101322"},{"key":"e_1_2_13_205_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00418-009-0575-3"},{"key":"e_1_2_13_206_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.cmet.2015.09.013"},{"key":"e_1_2_13_207_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.exphem.2006.05.022"},{"key":"e_1_2_13_208_1","doi-asserted-by":"publisher","DOI":"10.2337\/db15-0340"},{"key":"e_1_2_13_209_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.bbrc.2014.07.124"},{"key":"e_1_2_13_210_1","doi-asserted-by":"publisher","DOI":"10.1016\/S1471-4906(02)02274-3"},{"key":"e_1_2_13_211_1","doi-asserted-by":"publisher","DOI":"10.1038\/nri2327"},{"key":"e_1_2_13_212_1","doi-asserted-by":"publisher","DOI":"10.3389\/fimmu.2015.00394"},{"key":"e_1_2_13_213_1","doi-asserted-by":"publisher","DOI":"10.1097\/ACI.0b013e32832e9af1"},{"key":"e_1_2_13_214_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.tips.2004.09.007"},{"key":"e_1_2_13_215_1","first-page":"1","volume":"18","author":"Theoharides T. C.","year":"1996","journal-title":"Tissue React."},{"key":"e_1_2_13_216_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.bbadis.2011.06.004"},{"key":"e_1_2_13_217_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.clinthera.2015.04.002"},{"key":"e_1_2_13_218_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.immuni.2012.07.007"},{"key":"e_1_2_13_219_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.autrev.2015.04.008"},{"key":"e_1_2_13_220_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.coi.2009.09.010"},{"key":"e_1_2_13_221_1","doi-asserted-by":"publisher","DOI":"10.1038\/nri2018"},{"key":"e_1_2_13_222_1","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.1222878110"},{"key":"e_1_2_13_223_1","doi-asserted-by":"publisher","DOI":"10.1111\/1523-1747.ep12326075"},{"key":"e_1_2_13_224_1","doi-asserted-by":"publisher","DOI":"10.1182\/blood-2013-10-534685"},{"key":"e_1_2_13_225_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.immuni.2012.09.022"},{"key":"e_1_2_13_226_1","doi-asserted-by":"publisher","DOI":"10.1038\/nri915"}],"container-title":["Experimental Dermatology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1111%2Fexd.13288","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/exd.13288","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,6,14]],"date-time":"2025-06-14T15:17:58Z","timestamp":1749914278000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1111\/exd.13288"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2017,4,2]]},"references-count":225,"journal-issue":{"issue":"9","published-print":{"date-parts":[[2017,9]]}},"alternative-id":["10.1111\/exd.13288"],"URL":"https:\/\/doi.org\/10.1111\/exd.13288","archive":["Portico"],"relation":{},"ISSN":["0906-6705","1600-0625"],"issn-type":[{"value":"0906-6705","type":"print"},{"value":"1600-0625","type":"electronic"}],"subject":[],"published":{"date-parts":[[2017,4,2]]}}}