{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,23]],"date-time":"2026-10-23T20:23:48Z","timestamp":1792787028991,"version":"4.5.0"},"reference-count":40,"publisher":"Wiley","issue":"9","license":[{"start":{"date-parts":[[2017,4,10]],"date-time":"2017-04-10T00:00:00Z","timestamp":1491782400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"funder":[{"name":"La Roche-Posay Dermatological Laboratory"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Experimental Dermatology"],"published-print":{"date-parts":[[2017,9]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:p>\n                    <jats:italic>Propionibacterium acnes<\/jats:italic>\n                    (\n                    <jats:italic>P.\u00a0acnes<\/jats:italic>\n                    ), the sebaceous gland and follicular keratinocytes are considered the three actors involved in the development of acne. This exploratory study investigated the characteristics of the skin microbiota in subjects with acne and determined microbiota changes after 28\u00a0days of application of erythromycin 4% or a dermocosmetic. Skin microbiota were collected under axenic conditions from comedones, papulo\u2010pustular lesions and non\u2010lesional skin areas from subjects with mild to moderate acne according to the GEA grading using swabs. Samples were characterized using a high\u2010throughput sequencing approach that targets a portion of the bacterial 16S rRNA gene. Overall, microbiota samples from 26 subjects showed an overabundance of Proteobacteria and Firmicutes and an under\u2010representation of Actinobacteria.\n                    <jats:italic>Staphylococci<\/jats:italic>\n                    were more abundant on the surface of comedones, papules and pustules (\n                    <jats:italic>P<\/jats:italic>\n                    =.004 and\n                    <jats:italic>P<\/jats:italic>\n                    =.003 respectively) than on non\u2010lesional skin. Their proportions increased significantly with acne severity (\n                    <jats:italic>P<\/jats:italic>\n                    &lt;.05 between GEA\u20102 and GEA\u20103).\n                    <jats:italic>Propionibacteria<\/jats:italic>\n                    represented less than 2% of the bacteria on the skin surface. At Day 28, only the number of Actinobacteria had decreased with erythromycin while the dermocosmetic decreased also the number of\n                    <jats:italic>Staphylococci<\/jats:italic>\n                    . A significant reduction (\n                    <jats:italic>P<\/jats:italic>\n                    &lt;.05) from Day 0 of comedones, papules and pustules with no significant difference between the products was observed. The bacterial diversity on all sampling areas was similar. The dermocosmetic decreased the number of Actinobacteria and\n                    <jats:italic>Staphylococcus<\/jats:italic>\n                    spp. after 28\u00a0days.\n                    <jats:italic>Staphylococcus<\/jats:italic>\n                    remained the predominant genus of the superficial skin microbiota. No significant reduction in\n                    <jats:italic>Staphylococcus<\/jats:italic>\n                    spp. was observed with the topical antibiotic.\n                  <\/jats:p>","DOI":"10.1111\/exd.13296","type":"journal-article","created":{"date-parts":[[2017,1,17]],"date-time":"2017-01-17T13:28:22Z","timestamp":1484659702000},"page":"798-803","source":"Crossref","is-referenced-by-count":173,"title":["Skin microbiome and\n                    <i>acne vulgaris<\/i>\n                    :\n                    <i>Staphylococcus<\/i>\n                    , a new actor in acne"],"prefix":"10.1111","volume":"26","author":[{"given":"Brigitte","family":"Dreno","sequence":"first","affiliation":[{"name":"Department of Dermatology Nantes University Hospital  Nantes France"},{"name":"CIC, Inserm U892\u2010CNRS 6299  Nantes France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Richard","family":"Martin","sequence":"additional","affiliation":[{"name":"L'Or\u00e9al Research and Innovation  Tours France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Dominique","family":"Moyal","sequence":"additional","affiliation":[{"name":"La Roche\u2010Posay Dermatological Laboratories  Asni\u00e8res France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jessica B.","family":"Henley","sequence":"additional","affiliation":[{"name":"Cooperative Institute for Research in Environmental Sciences University of Colorado  Boulder CO USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Amir","family":"Khammari","sequence":"additional","affiliation":[{"name":"Department of Dermatology Nantes University Hospital  Nantes France"},{"name":"CIC, Inserm U892\u2010CNRS 6299  Nantes France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-9335-4139","authenticated-orcid":false,"given":"Sophie","family":"Seit\u00e9","sequence":"additional","affiliation":[{"name":"La Roche\u2010Posay Dermatological Laboratories  Asni\u00e8res France"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2017,4,10]]},"reference":[{"key":"e_1_2_7_2_1","doi-asserted-by":"publisher","DOI":"10.1038\/nrmicro2537"},{"key":"e_1_2_7_3_1","doi-asserted-by":"publisher","DOI":"10.1126\/science.1171700"},{"key":"e_1_2_7_4_1","first-page":"660","volume":"12","author":"Domizio J.","year":"2016","journal-title":"Rev. Med. Suisse"},{"key":"e_1_2_7_5_1","first-page":"127","volume":"14","author":"Sanchez D. A.","year":"2015","journal-title":"J. Drugs Dermatol."},{"key":"e_1_2_7_6_1","doi-asserted-by":"publisher","DOI":"10.1111\/ajd.12253"},{"key":"e_1_2_7_7_1","doi-asserted-by":"publisher","DOI":"10.1111\/bjd.14967"},{"key":"e_1_2_7_8_1","first-page":"582","volume":"10","author":"Bellew S.","year":"2011","journal-title":"J. Drugs Dermatol."},{"key":"e_1_2_7_9_1","first-page":"615","volume":"8","author":"Bhambri S.","year":"2009","journal-title":"J. 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