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Recently,\n                    <jats:styled-content style=\"fixed-case\">AMP<\/jats:styled-content>\n                    s\/\n                    <jats:styled-content style=\"fixed-case\">HDP<\/jats:styled-content>\n                    s were shown to have important biological functions, including inducing cell proliferation, migration and differentiation; regulating inflammatory responses; controlling the production of various cytokines\/chemokines; promoting wound healing; and improving skin barrier function. Despite the fact that\n                    <jats:styled-content style=\"fixed-case\">AMP<\/jats:styled-content>\n                    s\/\n                    <jats:styled-content style=\"fixed-case\">HDP<\/jats:styled-content>\n                    s protect our body, several studies have hypothesized that these molecules actively contribute to the pathogenesis of various skin diseases. For example,\n                    <jats:styled-content style=\"fixed-case\">AMP<\/jats:styled-content>\n                    s\/\n                    <jats:styled-content style=\"fixed-case\">HDP<\/jats:styled-content>\n                    s play crucial roles in the pathological processes of psoriasis, atopic dermatitis, rosacea, acne vulgaris, systemic lupus erythematosus and systemic sclerosis. Thus,\n                    <jats:styled-content style=\"fixed-case\">AMP<\/jats:styled-content>\n                    s\/\n                    <jats:styled-content style=\"fixed-case\">HDP<\/jats:styled-content>\n                    s may be a double\u2010edged sword, promoting cutaneous immunity while simultaneously initiating the pathogenesis of some skin disorders. This review will describe the most common skin\u2010derived\n                    <jats:styled-content style=\"fixed-case\">AMP<\/jats:styled-content>\n                    s\/\n                    <jats:styled-content style=\"fixed-case\">HDP<\/jats:styled-content>\n                    s (defensins, cathelicidins, S100 proteins, ribonucleases and dermcidin) and discuss the biology and both the positive and negative aspects of these\n                    <jats:styled-content style=\"fixed-case\">AMP<\/jats:styled-content>\n                    s\/\n                    <jats:styled-content style=\"fixed-case\">HDP<\/jats:styled-content>\n                    s in skin inflammatory\/infectious diseases. Understanding the regulation, functions and mechanisms of\n                    <jats:styled-content style=\"fixed-case\">AMP<\/jats:styled-content>\n                    s\/\n                    <jats:styled-content style=\"fixed-case\">HDP<\/jats:styled-content>\n                    s may offer new therapeutic opportunities in the treatment of various skin disorders.\n                  <\/jats:p>","DOI":"10.1111\/exd.13314","type":"journal-article","created":{"date-parts":[[2017,2,13]],"date-time":"2017-02-13T02:22:44Z","timestamp":1486952564000},"page":"989-998","source":"Crossref","is-referenced-by-count":164,"title":["Friends or Foes? 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Thailand"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Panjit","family":"Chieosilapatham","sequence":"additional","affiliation":[{"name":"Atopy (Allergy) Research Center Juntendo University Graduate School of Medicine  Tokyo Japan"},{"name":"Department of Dermatology and Allergology Juntendo University Graduate School of Medicine  Tokyo Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hideoki","family":"Ogawa","sequence":"additional","affiliation":[{"name":"Atopy (Allergy) Research Center Juntendo University Graduate School of Medicine  Tokyo 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