{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,7]],"date-time":"2026-10-07T23:10:22Z","timestamp":1791414622493,"version":"4.3.3"},"reference-count":25,"publisher":"Wiley","issue":"10","license":[{"start":{"date-parts":[[2017,5,2]],"date-time":"2017-05-02T00:00:00Z","timestamp":1493683200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/501100002428","name":"Austrian Science Fund","doi-asserted-by":"publisher","award":["P23801"],"award-info":[{"award-number":["P23801"]}],"id":[{"id":"10.13039\/501100002428","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100002428","name":"Austrian Science Fund","doi-asserted-by":"publisher","award":["P28004"],"award-info":[{"award-number":["P28004"]}],"id":[{"id":"10.13039\/501100002428","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Experimental Dermatology"],"published-print":{"date-parts":[[2017,10]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:p>\n                    The expression of filaggrin in differentiated keratinocytes and the association of filaggrin mutations with ichthyosis vulgaris and atopic dermatitis suggest that this prototypical member of the S100 fused\u2010type protein (\n                    <jats:styled-content style=\"fixed-case\">SFTP<\/jats:styled-content>\n                    ) family plays a key role in the epidermal barrier to the environment. Here, we report that\n                    <jats:styled-content style=\"fixed-case\">SFTP<\/jats:styled-content>\n                    genes are present not only in amniotes but also in amphibians. Four\n                    <jats:styled-content style=\"fixed-case\">SFTP<\/jats:styled-content>\n                    s are expressed in the skin of the frog\n                    <jats:italic>Xenopus laevis<\/jats:italic>\n                    . The results of this study indicate that filaggrin has evolved from an ancestral\n                    <jats:styled-content style=\"fixed-case\">SFTP<\/jats:styled-content>\n                    that may have contributed to skin modifications during the evolutionary transition to terrestrial life.\n                  <\/jats:p>","DOI":"10.1111\/exd.13317","type":"journal-article","created":{"date-parts":[[2017,2,13]],"date-time":"2017-02-13T02:42:42Z","timestamp":1486953762000},"page":"955-957","source":"Crossref","is-referenced-by-count":19,"title":["Filaggrin has evolved from an \u201cS100 fused\u2010type protein\u201d (\n                    <scp>SFTP<\/scp>\n                    ) gene present in a common ancestor of amphibians and mammals"],"prefix":"10.1111","volume":"26","author":[{"given":"Veronika","family":"Mlitz","sequence":"first","affiliation":[{"name":"Research Division of Biology and Pathobiology of the Skin Department of Dermatology Medical University of Vienna Vienna Austria"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tajamul","family":"Hussain","sequence":"additional","affiliation":[{"name":"Research Division of Biology and Pathobiology of the Skin Department of Dermatology Medical University of Vienna Vienna Austria"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Erwin","family":"Tschachler","sequence":"additional","affiliation":[{"name":"Research Division of Biology and Pathobiology of the Skin Department of Dermatology Medical University of Vienna Vienna Austria"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-5645-2036","authenticated-orcid":false,"given":"Leopold","family":"Eckhart","sequence":"additional","affiliation":[{"name":"Research Division of Biology and Pathobiology of the Skin Department of Dermatology Medical University of Vienna Vienna 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