{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,4]],"date-time":"2026-06-04T15:25:37Z","timestamp":1780586737883,"version":"3.54.1"},"reference-count":9,"publisher":"Wiley","issue":"10","license":[{"start":{"date-parts":[[2017,4,21]],"date-time":"2017-04-21T00:00:00Z","timestamp":1492732800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/501100003625","name":"Ministry of Health and Welfare","doi-asserted-by":"publisher","award":["HN12C0061"],"award-info":[{"award-number":["HN12C0061"]}],"id":[{"id":"10.13039\/501100003625","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Experimental Dermatology"],"published-print":{"date-parts":[[2017,10]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>Sebum production and excretion is a primary function of the sebaceous glands, but abnormally increased sebum production is a major cause of acne vulgaris. To identify a new candidate that regulates sebum production, we investigated the possible inhibitory effects of apple polyphenols (<jats:styled-content style=\"fixed-case\">APP<\/jats:styled-content>) purified from unripe apples on primary cultured human sebocytes and in patients with acne vulgaris. Dexamethasone (Dex) increased lipid synthesis and expression of the sterol response element\u2010binding protein 1 (<jats:styled-content style=\"fixed-case\">SREBP<\/jats:styled-content> 1) and its target enzymes, acetyl\u2010CoA carboxylase (<jats:styled-content style=\"fixed-case\">ACC<\/jats:styled-content>) and fatty acid synthase (<jats:styled-content style=\"fixed-case\">FAS<\/jats:styled-content>), in the sebocytes. However, <jats:styled-content style=\"fixed-case\">APP<\/jats:styled-content> inhibited Dex\u2010induced lipid production and expression of <jats:styled-content style=\"fixed-case\">SREBP<\/jats:styled-content>\u20101, <jats:styled-content style=\"fixed-case\">ACC<\/jats:styled-content> and <jats:styled-content style=\"fixed-case\">FAS<\/jats:styled-content>. <jats:styled-content style=\"fixed-case\">APP<\/jats:styled-content> also inhibited the increase in the expression and activation of glucocorticoid receptor in the sebocytes. Taken together, these results suggest that <jats:styled-content style=\"fixed-case\">APP<\/jats:styled-content> may be useful to regulate sebum production and may alleviate sebum\u2010involved skin disease, such as acne vulgaris.<\/jats:p>","DOI":"10.1111\/exd.13319","type":"journal-article","created":{"date-parts":[[2017,2,13]],"date-time":"2017-02-13T07:42:36Z","timestamp":1486971756000},"page":"958-960","source":"Crossref","is-referenced-by-count":30,"title":["Polyphenol\u2010rich apple extract inhibits dexamethasone\u2010induced sebaceous lipids production by regulating <scp>SREBP<\/scp>1 expression"],"prefix":"10.1111","volume":"26","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-8656-2263","authenticated-orcid":false,"given":"Kyung\u2010Eun","family":"Lee","sequence":"first","affiliation":[{"name":"R&amp;I Center Cosmax Co. Ltd.  Seongnam South Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jong\u2010Kyung","family":"Youm","sequence":"additional","affiliation":[{"name":"R&amp;I Center Cosmax Co. Ltd.  Seongnam South Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Weon Ju","family":"Lee","sequence":"additional","affiliation":[{"name":"Department of Dermatology Kyungpook National University School of Medicine  Daegu South Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Seunghyun","family":"Kang","sequence":"additional","affiliation":[{"name":"R&amp;I Center Cosmax Co. Ltd.  Seongnam South Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Youn Joon","family":"Kim","sequence":"additional","affiliation":[{"name":"R&amp;I Center Cosmax Co. Ltd.  Seongnam South Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2017,4,21]]},"reference":[{"key":"e_1_2_2_2_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.clindermatol.2004.03.004"},{"key":"e_1_2_2_3_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00403-008-0879-5"},{"key":"e_1_2_2_4_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.0906-6705.2005.0285a.x"},{"key":"e_1_2_2_5_1","doi-asserted-by":"publisher","DOI":"10.1136\/bmj.280.6229.1394"},{"key":"e_1_2_2_6_1","doi-asserted-by":"publisher","DOI":"10.4161\/derm.3.1.13900"},{"key":"e_1_2_2_7_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1600-0625.2009.00890.x"},{"key":"e_1_2_2_8_1","doi-asserted-by":"publisher","DOI":"10.1111\/bjd.12009"},{"key":"e_1_2_2_9_1","doi-asserted-by":"publisher","DOI":"10.1152\/ajpendo.90555.2008"},{"key":"e_1_2_2_10_1","doi-asserted-by":"publisher","DOI":"10.1677\/JOE-08-0054"}],"container-title":["Experimental Dermatology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1111%2Fexd.13319","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/exd.13319","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,9,24]],"date-time":"2023-09-24T14:19:00Z","timestamp":1695565140000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1111\/exd.13319"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2017,4,21]]},"references-count":9,"journal-issue":{"issue":"10","published-print":{"date-parts":[[2017,10]]}},"alternative-id":["10.1111\/exd.13319"],"URL":"https:\/\/doi.org\/10.1111\/exd.13319","archive":["Portico"],"relation":{},"ISSN":["0906-6705","1600-0625"],"issn-type":[{"value":"0906-6705","type":"print"},{"value":"1600-0625","type":"electronic"}],"subject":[],"published":{"date-parts":[[2017,4,21]]}}}