{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,1,28]],"date-time":"2026-01-28T10:26:15Z","timestamp":1769595975929,"version":"3.49.0"},"reference-count":9,"publisher":"Wiley","issue":"7","license":[{"start":{"date-parts":[[2017,4,21]],"date-time":"2017-04-21T00:00:00Z","timestamp":1492732800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Experimental Dermatology"],"published-print":{"date-parts":[[2017,7]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>Immune checkpoint inhibitors and kinase inhibitors have improved prognosis of malignant melanoma (<jats:styled-content style=\"fixed-case\">MM<\/jats:styled-content>) patients. However, these therapies cannot completely overcome the metastasis of <jats:styled-content style=\"fixed-case\">MM<\/jats:styled-content>. Thus, development of new therapy against metastasis should be required. A first step towards this goal, the aim of this study, is to establish a model of pulmonary metastasis from primary cutaneous <jats:styled-content style=\"fixed-case\">MM<\/jats:styled-content> and a monitoring system. B16\u2010F10, a murine melanoma cell line, was subcutaneously injected into the pinna of mice. The pinna was excised when the lesion was detected. A metastatic nodule on T2\u2010weighted imaging was detected 4\u00a0weeks after resection of the pinna. Lung metastases were observed in 37.5% (6\/16) of the specimens. We established a novel murine model of the high pulmonary metastasis of <jats:styled-content style=\"fixed-case\">MM<\/jats:styled-content>. The <jats:styled-content style=\"fixed-case\">MRI<\/jats:styled-content> was useful for observations of the growth of the metastatic lesions in the lungs without dissection.<\/jats:p>","DOI":"10.1111\/exd.13327","type":"journal-article","created":{"date-parts":[[2017,3,7]],"date-time":"2017-03-07T11:26:37Z","timestamp":1488885997000},"page":"619-621","source":"Crossref","is-referenced-by-count":3,"title":["A pulmonary metastatic model of murine melanoma assessed by magnetic resonance imaging"],"prefix":"10.1111","volume":"26","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-6109-0156","authenticated-orcid":false,"given":"Takafumi","family":"Numata","sequence":"first","affiliation":[{"name":"Department of Dermatology Tokyo Medical University  Tokyo Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Shigeru","family":"Kiryu","sequence":"additional","affiliation":[{"name":"Department of Radiology Institute of Medical Science University of Tokyo  Tokyo Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Tatsuo","family":"Maeda","sequence":"additional","affiliation":[{"name":"Department of Dermatology Tokyo Medical University  Tokyo Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Chizu","family":"Egusa","sequence":"additional","affiliation":[{"name":"Department of Dermatology Tokyo Medical University  Tokyo Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ryoji","family":"Tsuboi","sequence":"additional","affiliation":[{"name":"Department of Dermatology Tokyo Medical University  Tokyo Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Kazutoshi","family":"Harada","sequence":"additional","affiliation":[{"name":"Department of Dermatology Tokyo Medical University  Tokyo Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2017,4,21]]},"reference":[{"key":"e_1_2_10_2_1","doi-asserted-by":"publisher","DOI":"10.1200\/JCO.2009.23.4799"},{"key":"e_1_2_10_3_1","doi-asserted-by":"publisher","DOI":"10.1016\/S1470-2045(16)30366-7"},{"key":"e_1_2_10_4_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ejca.2016.05.005"},{"key":"e_1_2_10_5_1","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0094945"},{"key":"e_1_2_10_6_1","first-page":"115","volume":"12","author":"Ishibashi S.","year":"2004","journal-title":"Oncol. 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