{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,20]],"date-time":"2026-09-20T08:34:24Z","timestamp":1789893264414,"version":"4.0.1"},"reference-count":25,"publisher":"Wiley","issue":"12","license":[{"start":{"date-parts":[[2017,5,12]],"date-time":"2017-05-12T00:00:00Z","timestamp":1494547200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/501100000646","name":"Japan Society for the Promotion of Science London","doi-asserted-by":"publisher","award":["26860861"],"award-info":[{"award-number":["26860861"]}],"id":[{"id":"10.13039\/501100000646","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Experimental Dermatology"],"published-print":{"date-parts":[[2017,12]]},"abstract":"Abstract<\/jats:title>\n \n Type\n XVII<\/jats:styled-content>\n collagen (\n COL<\/jats:styled-content>\n 17) and the non\u2010collagenous 16A (\n NC<\/jats:styled-content>\n 16A) domain is regarded as the major pathogenic domains for bullous pemphigoid (\n BP<\/jats:styled-content>\n ). Some patients with\n BP<\/jats:styled-content>\n have autoantibodies against parts of\n COL<\/jats:styled-content>\n 17 outside the\n NC<\/jats:styled-content>\n 16A domain (hereinafter the non\u2010\n NC<\/jats:styled-content>\n 16A domain) and show less inflammatory manifestations. There were no significant differences in titres and IgG subclasses between\n NC<\/jats:styled-content>\n 16A\u2010\n BP<\/jats:styled-content>\n and non\u2010\n NC<\/jats:styled-content>\n 16A\u2010\n BP<\/jats:styled-content>\n as determined by indirect immunofluorescent microscopy. The neutrophil activation capacities determined by\n ROS<\/jats:styled-content>\n release did not differ between\n NC<\/jats:styled-content>\n 16A\u2010\n BP<\/jats:styled-content>\n and non\u2010\n NC<\/jats:styled-content>\n 16A\u2010\n BP<\/jats:styled-content>\n . However,\n NC<\/jats:styled-content>\n 16A\u2010\n BP<\/jats:styled-content>\n IgG depleted\n COL<\/jats:styled-content>\n 17 in a dose\u2010dependent manner. Treatment with\n NC<\/jats:styled-content>\n 16A\u2010\n BP<\/jats:styled-content>\n IgG, but not with non\u2010\n NC<\/jats:styled-content>\n 16A\u2010\n BP<\/jats:styled-content>\n IgG, significantly decreased the adhesion strength. We speculate that the differences in clinical severity between\n NC<\/jats:styled-content>\n 16A\u2010\n BP<\/jats:styled-content>\n and non\u2010\n NC<\/jats:styled-content>\n 16A\u2010\n BP<\/jats:styled-content>\n relate to the degree of\n COL<\/jats:styled-content>\n 17 depletion.\n <\/jats:p>","DOI":"10.1111\/exd.13331","type":"journal-article","created":{"date-parts":[[2017,3,7]],"date-time":"2017-03-07T06:52:40Z","timestamp":1488869560000},"page":"1171-1174","source":"Crossref","is-referenced-by-count":14,"title":["Autoantibodies of non\u2010inflammatory bullous pemphigoid hardly deplete type\n XVII<\/scp>\n collagen of keratinocytes"],"prefix":"10.1111","volume":"26","author":[{"given":"Keisuke","family":"Imafuku","sequence":"first","affiliation":[{"name":"Department of Dermatology Graduate School of Medicine Hokkaido University Sapporo 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