{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,13]],"date-time":"2026-03-13T21:23:20Z","timestamp":1773437000080,"version":"3.50.1"},"reference-count":35,"publisher":"Wiley","issue":"7","license":[{"start":{"date-parts":[[2017,5,9]],"date-time":"2017-05-09T00:00:00Z","timestamp":1494288000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Experimental Dermatology"],"published-print":{"date-parts":[[2017,7]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>The skin is known to adapt to <jats:styled-content style=\"fixed-case\">UV<\/jats:styled-content> exposures, that is become less sensitive to sunburn. Reported decreases in sensitivity vary widely from well over 10\u2010fold down to a negligible 10%. This appears to depend importantly on the <jats:styled-content style=\"fixed-case\">UV<\/jats:styled-content> irradiation spectrum to which the skin adapts and on the <jats:styled-content style=\"fixed-case\">UV<\/jats:styled-content> irradiation spectrum that is used to test the sensitivity. The sensitivity is conventionally and generally assessed by the reciprocal of the minimal erythema dose (<jats:styled-content style=\"fixed-case\">MED<\/jats:styled-content>): the <jats:styled-content style=\"fixed-case\">UV<\/jats:styled-content> dose causing a just perceptible reddening of the skin after 8\u201024\u00a0hours. However, <jats:styled-content style=\"fixed-case\">MED<\/jats:styled-content> is much too subtle for everyday life: people will not notice a minimal reddening and commonly consider themselves sunburnt at considerably higher <jats:styled-content style=\"fixed-case\">UV<\/jats:styled-content> doses causing an intense reddening. Levels of adaptation of a well\u2010tanned skin may be substantially higher at these more intense levels of reddening than <jats:styled-content style=\"fixed-case\">MED<\/jats:styled-content> levels. This expectation is based on the fact that people with a constitutively coloured skin may show moderate differences in <jats:styled-content style=\"fixed-case\">MED<\/jats:styled-content> compared with fair\u2010skinned people but far less steep increases in reddening with overexposures to solar\u2010simulated radiation (<jats:styled-content style=\"fixed-case\">SSR<\/jats:styled-content>). <jats:styled-content style=\"fixed-case\">UVA<\/jats:styled-content> exposure is known to enhance pigmentation and may thus be important in protection against overexposure to <jats:styled-content style=\"fixed-case\">SSR<\/jats:styled-content>.<\/jats:p>","DOI":"10.1111\/exd.13332","type":"journal-article","created":{"date-parts":[[2017,3,7]],"date-time":"2017-03-07T12:52:54Z","timestamp":1488891174000},"page":"557-562","source":"Crossref","is-referenced-by-count":39,"title":["UV adaptation: Pigmentation and protection against overexposure"],"prefix":"10.1111","volume":"26","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-6264-3982","authenticated-orcid":false,"given":"Frank R.","family":"de Gruijl","sequence":"first","affiliation":[{"name":"Department of Dermatology Leiden University Medical Center  Leiden The Netherlands"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2017,5,9]]},"reference":[{"key":"e_1_2_10_2_1","first-page":"403","volume":"35","author":"Miescher G.","year":"1930","journal-title":"Strahlentherapie"},{"key":"e_1_2_10_3_1","first-page":"591","volume":"119","author":"Rottier P. 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