{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,8]],"date-time":"2026-03-08T19:50:17Z","timestamp":1772999417007,"version":"3.50.1"},"reference-count":52,"publisher":"Wiley","issue":"10","license":[{"start":{"date-parts":[[2017,5,9]],"date-time":"2017-05-09T00:00:00Z","timestamp":1494288000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/501100004587","name":"Instituto de Salud Carlos III","doi-asserted-by":"publisher","award":["PT13\/0001"],"award-info":[{"award-number":["PT13\/0001"]}],"id":[{"id":"10.13039\/501100004587","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Experimental Dermatology"],"published-print":{"date-parts":[[2017,10]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>Sunlight exposure induces signalling pathways leading to the activation of melanin synthesis and tanning response. Micro<jats:styled-content style=\"fixed-case\">RNA<\/jats:styled-content>s (mi<jats:styled-content style=\"fixed-case\">RNA<\/jats:styled-content>s) can regulate the expression of genes involved in pigmentation pathways by binding to the complementary sequence in their 3\u2032untranslated regions (3\u2032<jats:styled-content style=\"fixed-case\">UTR<\/jats:styled-content>s). Therefore, 3\u2032<jats:styled-content style=\"fixed-case\">UTR SNP<\/jats:styled-content>s are predicted to modify the ability of mi<jats:styled-content style=\"fixed-case\">RNA<\/jats:styled-content>s to target genes, resulting in differential gene expression. In this study, we investigated the role in pigmentation and sun\u2010sensitivity traits, as well as in melanoma susceptibility, of 38 different 3\u2032<jats:styled-content style=\"fixed-case\">UTR SNP<\/jats:styled-content>s from 38 pigmentation\u2010related genes. A total of 869 individuals of Spanish origin (526 melanoma cases and 343 controls) were analysed. The association of genotypic data with pigmentation traits was analysed via logistic regression. Web\u2010based tools for predicting the effect of genetic variants in micro<jats:styled-content style=\"fixed-case\">RNA<\/jats:styled-content>\u2010binding sites in 3\u2032<jats:styled-content style=\"fixed-case\">UTR<\/jats:styled-content> gene regions were also used. Seven 3\u2032<jats:styled-content style=\"fixed-case\">UTR SNP<\/jats:styled-content>s showed a potential implication in melanoma risk phenotypes. This association is especially noticeable for two of them, rs2325813 in the <jats:italic><jats:styled-content style=\"fixed-case\">MLPH<\/jats:styled-content><\/jats:italic> gene and rs752107 in the <jats:italic><jats:styled-content style=\"fixed-case\">WNT<\/jats:styled-content>3A<\/jats:italic> gene. These two <jats:styled-content style=\"fixed-case\">SNP<\/jats:styled-content>s were predicted to disrupt a mi<jats:styled-content style=\"fixed-case\">RNA<\/jats:styled-content>\u2010binding site and to impact on mi<jats:styled-content style=\"fixed-case\">RNA<\/jats:styled-content>\u2010<jats:styled-content style=\"fixed-case\">mRNA<\/jats:styled-content> interaction. To our knowledge, this is the first time that these two 3\u2032<jats:styled-content style=\"fixed-case\">UTR SNP<\/jats:styled-content>s have been associated with sun\u2010sensitivity traits. We state the potential implication of these <jats:styled-content style=\"fixed-case\">SNP<\/jats:styled-content>s in human pigmentation and sensitivity to sunlight, possibly as a result of changes in the level of gene expression through the disruption of putative mi<jats:styled-content style=\"fixed-case\">RNA<\/jats:styled-content>\u2010binding sites.<\/jats:p>","DOI":"10.1111\/exd.13333","type":"journal-article","created":{"date-parts":[[2017,3,7]],"date-time":"2017-03-07T12:52:37Z","timestamp":1488891157000},"page":"896-903","source":"Crossref","is-referenced-by-count":11,"title":["Genetic 3\u2032<scp>UTR<\/scp> variation is associated with human pigmentation characteristics and sensitivity to sunlight"],"prefix":"10.1111","volume":"26","author":[{"given":"Barbara","family":"Hernando","sequence":"first","affiliation":[{"name":"Department of Medicine Jaume I University of Castellon  Castellon Spain"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Maria","family":"Pe\u00f1a\u2010Chilet","sequence":"additional","affiliation":[{"name":"Department of Medical Oncology Biomedical Research Institute \u2010 INCLIVA  Valencia Spain"},{"name":"Network Centre for Biomedical Cancer Research (CIBERONC)  Valencia Spain"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Maider","family":"Ibarrola\u2010Villava","sequence":"additional","affiliation":[{"name":"Department of Medical Oncology Biomedical Research Institute \u2010 INCLIVA  Valencia Spain"},{"name":"Network Centre for Biomedical Cancer Research (CIBERONC)  Valencia Spain"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Manuel","family":"Martin\u2010Gonzalez","sequence":"additional","affiliation":[{"name":"Department of Dermatology Ramon y Cajal Hospital  Madrid Spain"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Cristina","family":"Gomez\u2010Fernandez","sequence":"additional","affiliation":[{"name":"Department of Dermatology La Paz Hospital  Madrid Spain"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Gloria","family":"Ribas","sequence":"additional","affiliation":[{"name":"Department of Medical Oncology Biomedical Research Institute \u2010 INCLIVA  Valencia Spain"},{"name":"Network Centre for Biomedical Cancer Research (CIBERONC)  Valencia Spain"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-5252-563X","authenticated-orcid":false,"given":"Conrado","family":"Martinez\u2010Cadenas","sequence":"additional","affiliation":[{"name":"Department of Medicine Jaume I University of Castellon  Castellon Spain"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2017,5,9]]},"reference":[{"key":"e_1_2_8_2_1","doi-asserted-by":"publisher","DOI":"10.1158\/1055-9965.EPI-14-0295"},{"key":"e_1_2_8_3_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.mrrev.2010.06.002"},{"key":"e_1_2_8_4_1","doi-asserted-by":"publisher","DOI":"10.1038\/ng.2007.13"},{"key":"e_1_2_8_5_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.semcdb.2013.03.013"},{"key":"e_1_2_8_6_1","doi-asserted-by":"publisher","DOI":"10.1002\/humu.20804"},{"key":"e_1_2_8_7_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1600-0625.2010.01115.x"},{"key":"e_1_2_8_8_1","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0019271"},{"key":"e_1_2_8_9_1","doi-asserted-by":"publisher","DOI":"10.1002\/ijc.29257"},{"key":"e_1_2_8_10_1","doi-asserted-by":"publisher","DOI":"10.1186\/1471-2407-13-160"},{"key":"e_1_2_8_11_1","doi-asserted-by":"publisher","DOI":"10.1038\/jid.2009.258"},{"key":"e_1_2_8_12_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1600-0625.2009.00846.x"},{"key":"e_1_2_8_13_1","first-page":"1341","volume":"39","author":"Bataille V.","year":"2003","journal-title":"Cancer"},{"key":"e_1_2_8_14_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-4632.2010.04474.x"},{"key":"e_1_2_8_15_1","doi-asserted-by":"publisher","DOI":"10.1038\/sj.jidsp.5640178"},{"key":"e_1_2_8_16_1","doi-asserted-by":"publisher","DOI":"10.1089\/jir.2005.25.1"},{"key":"e_1_2_8_17_1","doi-asserted-by":"publisher","DOI":"10.1146\/annurev.neuro.24.1.239"},{"key":"e_1_2_8_18_1","doi-asserted-by":"publisher","DOI":"10.4331\/wjbc.v5.i1.40"},{"key":"e_1_2_8_19_1","first-page":"1","volume":"29","author":"L\u00f3pez de Silanes I.","year":"2007","journal-title":"Cell Oncol."},{"key":"e_1_2_8_20_1","doi-asserted-by":"publisher","DOI":"10.1038\/nrg2290"},{"key":"e_1_2_8_21_1","first-page":"276","volume":"19","author":"Przyby\u0142a A.","year":"2015","journal-title":"Contemp. 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