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In the<jats:styled-content style=\"fixed-case\">PD<\/jats:styled-content>epidermolysis bullosa acquisita (<jats:styled-content style=\"fixed-case\">EBA<\/jats:styled-content>), the target autoantigen is type<jats:styled-content style=\"fixed-case\">VII<\/jats:styled-content>collagen. Current treatment options of<jats:styled-content style=\"fixed-case\">PD<\/jats:styled-content>, especially<jats:styled-content style=\"fixed-case\">EBA<\/jats:styled-content>, are limited and are mostly based on systemic immunosuppression. Animal models of<jats:styled-content style=\"fixed-case\">PD<\/jats:styled-content>have greatly advanced our understanding of<jats:styled-content style=\"fixed-case\">PD<\/jats:styled-content>pathogenesis. This has led to the identification of several novel therapeutic targets, including signalling molecules. Herein, the contribution of signalling molecules in the pathogenesis of the<jats:styled-content style=\"fixed-case\">PD EBA<\/jats:styled-content>and the effects of pharmacological targeting of these pathways are reviewed in detail. The p38<jats:styled-content style=\"fixed-case\">MAPK<\/jats:styled-content>,<jats:styled-content style=\"fixed-case\">ERK<\/jats:styled-content>1\/2,<jats:styled-content style=\"fixed-case\">AKT<\/jats:styled-content>,<jats:styled-content style=\"fixed-case\">PI<\/jats:styled-content>3K\u03b2, Hsp90,<jats:styled-content style=\"fixed-case\">ROR<\/jats:styled-content>\u03b1,<jats:styled-content style=\"fixed-case\">PDE<\/jats:styled-content>4, Src kinases and<jats:styled-content style=\"fixed-case\">CARD<\/jats:styled-content>9 have been demonstrated to be critically involved in<jats:styled-content style=\"fixed-case\">EBA<\/jats:styled-content>pathogenesis. With the advent of new signal transduction inhibitors, we expect that the so far poor prognosis of<jats:styled-content style=\"fixed-case\">EBA<\/jats:styled-content>and other<jats:styled-content style=\"fixed-case\">PD<\/jats:styled-content>will improve significantly in the future.<\/jats:p>","DOI":"10.1111\/exd.13335","type":"journal-article","created":{"date-parts":[[2017,3,7]],"date-time":"2017-03-07T13:18:39Z","timestamp":1488892719000},"page":"1179-1186","source":"Crossref","is-referenced-by-count":25,"title":["Signalling and targeted therapy of inflammatory cells in epidermolysis bullosa acquisita"],"prefix":"10.1111","volume":"26","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-1394-1737","authenticated-orcid":false,"given":"Ralf J.","family":"Ludwig","sequence":"first","affiliation":[{"name":"L\u00fcbeck Institute of Experimental Dermatology and Department of Dermatology University of L\u00fcbeck L\u00fcbeck Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2017,5,9]]},"reference":[{"key":"e_1_2_6_2_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMra020100"},{"key":"e_1_2_6_3_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jaut.2007.05.002"},{"key":"e_1_2_6_4_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa011592"},{"key":"e_1_2_6_5_1","doi-asserted-by":"publisher","DOI":"10.1146\/annurev-pathol-012615-044313"},{"key":"e_1_2_6_6_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(12)61140-4"},{"key":"e_1_2_6_7_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.molmed.2013.06.003"},{"key":"e_1_2_6_8_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jid.2016.07.013"},{"key":"e_1_2_6_9_1","first-page":"423","volume":"144","author":"Heimbach L.","year":"2009","journal-title":"G. 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