{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,23]],"date-time":"2026-10-23T23:26:48Z","timestamp":1792798008419,"version":"4.5.0"},"reference-count":136,"publisher":"Wiley","issue":"4","license":[{"start":{"date-parts":[[2017,5,9]],"date-time":"2017-05-09T00:00:00Z","timestamp":1494288000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"name":"Valeant Pharmaceuticals North America LLC","id":[{"id":"https:\/\/ror.org\/01zgpn844","id-type":"ROR","asserted-by":"crossref"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Experimental Dermatology"],"published-print":{"date-parts":[[2018,4]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:p>\n                    Atopic dermatitis (\n                    <jats:styled-content style=\"fixed-case\">AD<\/jats:styled-content>\n                    ) and psoriasis are inflammatory skin diseases that negatively affect patients\u2019 quality of life. Although distinctions exist between these diseases, both are characterized by erythematous, thickened epidermal lesions that vary in intensity and affected body surface area. Early models of aetiology attributed symptoms of both diseases to cutaneous inflammation at lesion sites, but recent studies have established that activated immune mediators in the circulation drive disease severity. Activation of T helper 2 (Th2) and Th22 cells in the circulation appears to be the principal initiator of acute\n                    <jats:styled-content style=\"fixed-case\">AD<\/jats:styled-content>\n                    pathology, with the emergence of Th1 and Th17\/interleukin (\n                    <jats:styled-content style=\"fixed-case\">IL<\/jats:styled-content>\n                    )\u201023 pathway activation marking the transition to a chronic state. The Th17\/\n                    <jats:styled-content style=\"fixed-case\">IL<\/jats:styled-content>\n                    \u201023 pathway also has an important role in psoriasis. The role of systemic inflammation in AD and psoriasis is supported by the occurrence of non\u2010cutaneous comorbidities that affect patients, most of which intensify morbidity and disability associated with lesional skin. Atopic dermatitis is associated with allergic disorders consisting of the \u201catopic march,\u201d whereas psoriasis is frequently accompanied by psoriatic arthritis. Patients with both disorders are at significantly higher risk of obesity, metabolic disorders, and cardiovascular diseases, all of which feature inflammatory components in their pathology models. These insights have led to novel therapeutics aimed at addressing psoriasis by targeting tumor necrosis factor\u2010 and Th17\u2010related cytokine pathways. The success of these agents in psoriasis management is driving new therapeutic approaches for moderate\u2010to\u2010severe\n                    <jats:styled-content style=\"fixed-case\">AD<\/jats:styled-content>\n                    , including agents targeting the Th2 and Th17\/Th22 cytokine pathways.\n                  <\/jats:p>","DOI":"10.1111\/exd.13336","type":"journal-article","created":{"date-parts":[[2017,3,7]],"date-time":"2017-03-07T08:17:04Z","timestamp":1488874624000},"page":"409-417","source":"Crossref","is-referenced-by-count":195,"title":["Systemic immune mechanisms in atopic dermatitis and psoriasis with implications for treatment"],"prefix":"10.1111","volume":"27","author":[{"given":"Emma","family":"Guttman\u2010Yassky","sequence":"first","affiliation":[{"name":"Department of Dermatology Icahn School of Medicine at Mount Sinai  New York NY USA"},{"name":"Laboratory for Investigative Dermatology The Rockefeller University  New York NY USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"James G.","family":"Krueger","sequence":"additional","affiliation":[{"name":"Laboratory for Investigative Dermatology The Rockefeller University  New York NY USA"},{"name":"Center for Clinical and Translational Science The Rockefeller University  New York NY USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mark G.","family":"Lebwohl","sequence":"additional","affiliation":[{"name":"Department of Dermatology Icahn School of Medicine at Mount Sinai  New York NY USA"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2017,5,9]]},"reference":[{"key":"e_1_2_9_2_1","doi-asserted-by":"publisher","DOI":"10.2165\/00128071-200506060-00005"},{"key":"e_1_2_9_3_1","doi-asserted-by":"publisher","DOI":"10.1111\/bjd.13084"},{"key":"e_1_2_9_4_1","doi-asserted-by":"publisher","DOI":"10.1038\/jid.2010.251"},{"key":"e_1_2_9_5_1","doi-asserted-by":"publisher","DOI":"10.5021\/ad.2010.22.2.125"},{"key":"e_1_2_9_6_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jaci.2011.01.053"},{"key":"e_1_2_9_7_1","doi-asserted-by":"publisher","DOI":"10.1038\/jid.2012.339"},{"key":"e_1_2_9_8_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jaci.2014.11.015"},{"key":"e_1_2_9_9_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jaci.2007.03.006"},{"key":"e_1_2_9_10_1","doi-asserted-by":"publisher","DOI":"10.4049\/jimmunol.171.6.3262"},{"key":"e_1_2_9_11_1","doi-asserted-by":"publisher","DOI":"10.1002\/(SICI)1097-0029(19970815)38:4<361::AID-JEMT4>3.0.CO;2-M"},{"key":"e_1_2_9_12_1","doi-asserted-by":"publisher","DOI":"10.1146\/annurev-med-042915-103905"},{"key":"e_1_2_9_13_1","doi-asserted-by":"publisher","DOI":"10.3390\/jcm4050858"},{"key":"e_1_2_9_14_1","doi-asserted-by":"publisher","DOI":"10.1067\/mjd.2002.120568"},{"key":"e_1_2_9_15_1","doi-asserted-by":"publisher","DOI":"10.1067\/mai.2000.106484"},{"key":"e_1_2_9_16_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jaci.2014.08.008"},{"key":"e_1_2_9_17_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jaci.2014.10.013"},{"key":"e_1_2_9_18_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jaci.2010.12.1124"},{"key":"e_1_2_9_19_1","doi-asserted-by":"publisher","DOI":"10.1016\/0140-6736(91)90134-B"},{"key":"e_1_2_9_20_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jaad.2006.08.031"},{"key":"e_1_2_9_21_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jid.2016.09.037"},{"key":"e_1_2_9_22_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jaci.2009.09.031"},{"key":"e_1_2_9_23_1","doi-asserted-by":"publisher","DOI":"10.1038\/ng1767"},{"key":"e_1_2_9_24_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jaci.2012.07.012"},{"key":"e_1_2_9_25_1","doi-asserted-by":"publisher","DOI":"10.1038\/nrm910"},{"key":"e_1_2_9_26_1","doi-asserted-by":"publisher","DOI":"10.1038\/nri2735"},{"key":"e_1_2_9_27_1","doi-asserted-by":"publisher","DOI":"10.1038\/jid.2014.83"},{"key":"e_1_2_9_28_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jdermsci.2012.07.004"},{"key":"e_1_2_9_29_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jaci.2011.10.042"},{"key":"e_1_2_9_30_1","doi-asserted-by":"publisher","DOI":"10.2332\/allergolint.13-RAI-0564"},{"key":"e_1_2_9_31_1","doi-asserted-by":"publisher","DOI":"10.1084\/jem.20061308"},{"key":"e_1_2_9_32_1","doi-asserted-by":"publisher","DOI":"10.4049\/jimmunol.181.10.7420"},{"key":"e_1_2_9_33_1","doi-asserted-by":"publisher","DOI":"10.1038\/jid.2009.173"},{"key":"e_1_2_9_34_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.yexcr.2011.01.024"},{"key":"e_1_2_9_35_1","doi-asserted-by":"publisher","DOI":"10.4049\/jimmunol.1401740"},{"key":"e_1_2_9_36_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2133.2008.08769.x"},{"key":"e_1_2_9_37_1","doi-asserted-by":"publisher","DOI":"10.1038\/nrd3794"},{"key":"e_1_2_9_38_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2133.2008.08902.x"},{"key":"e_1_2_9_39_1","doi-asserted-by":"publisher","DOI":"10.4049\/jimmunol.181.12.8504"},{"key":"e_1_2_9_40_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jaci.2009.08.046"},{"key":"e_1_2_9_41_1","doi-asserted-by":"publisher","DOI":"10.1111\/jdv.12163"},{"key":"e_1_2_9_42_1","doi-asserted-by":"publisher","DOI":"10.1111\/all.12685"},{"key":"e_1_2_9_43_1","doi-asserted-by":"publisher","DOI":"10.1001\/jamadermatol.2014.3059"},{"key":"e_1_2_9_44_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jaci.2014.11.023"},{"key":"e_1_2_9_45_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jaci.2011.01.063"},{"key":"e_1_2_9_46_1","doi-asserted-by":"publisher","DOI":"10.1097\/DER.0000000000000034"},{"key":"e_1_2_9_47_1","doi-asserted-by":"publisher","DOI":"10.1097\/DER.0000000000000047"},{"key":"e_1_2_9_48_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jaad.2014.12.013"},{"key":"e_1_2_9_49_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jid.2016.08.022"},{"key":"e_1_2_9_50_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jaci.2003.12.591"},{"key":"e_1_2_9_51_1","first-page":"202","volume":"5","author":"Bantz S. K.","year":"2014","journal-title":"J. Clin. Cell. Immunol."},{"key":"e_1_2_9_52_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jaci.2004.01.778"},{"key":"e_1_2_9_53_1","doi-asserted-by":"publisher","DOI":"10.1186\/1471-5945-12-11"},{"key":"e_1_2_9_54_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jaci.2013.08.054"},{"key":"e_1_2_9_55_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jaci.2008.05.018"},{"key":"e_1_2_9_56_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jaad.2006.04.064"},{"key":"e_1_2_9_57_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1600-0625.2011.01261.x"},{"key":"e_1_2_9_58_1","doi-asserted-by":"publisher","DOI":"10.1177\/1203475415586332"},{"key":"e_1_2_9_59_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jaad.2006.08.040"},{"key":"e_1_2_9_60_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1468-3083.2010.03573.x"},{"key":"e_1_2_9_61_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2133.2007.07986.x"},{"key":"e_1_2_9_62_1","doi-asserted-by":"publisher","DOI":"10.1001\/archdermatol.2012.1401"},{"key":"e_1_2_9_63_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.amjmed.2015.05.041"},{"key":"e_1_2_9_64_1","doi-asserted-by":"publisher","DOI":"10.1093\/eurheartj\/ehp567"},{"key":"e_1_2_9_65_1","doi-asserted-by":"publisher","DOI":"10.1001\/archderm.143.12.1493"},{"key":"e_1_2_9_66_1","doi-asserted-by":"publisher","DOI":"10.1001\/archdermatol.2012.2502"},{"key":"e_1_2_9_67_1","doi-asserted-by":"publisher","DOI":"10.1038\/jid.2015.87"},{"key":"e_1_2_9_68_1","doi-asserted-by":"publisher","DOI":"10.1038\/jid.2009.321"},{"key":"e_1_2_9_69_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2133.2008.09020.x"},{"key":"e_1_2_9_70_1","doi-asserted-by":"publisher","DOI":"10.1038\/jid.2010.103"},{"key":"e_1_2_9_71_1","doi-asserted-by":"publisher","DOI":"10.5021\/ad.2016.28.1.74"},{"key":"e_1_2_9_72_1","doi-asserted-by":"publisher","DOI":"10.1038\/jid.2009.399"},{"key":"e_1_2_9_73_1","doi-asserted-by":"publisher","DOI":"10.1038\/jid.2009.112"},{"key":"e_1_2_9_74_1","doi-asserted-by":"publisher","DOI":"10.1001\/archdermatol.2011.119"},{"key":"e_1_2_9_75_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jaci.2016.01.015"},{"key":"e_1_2_9_76_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jaci.2015.03.032"},{"key":"e_1_2_9_77_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jaci.2015.08.027"},{"key":"e_1_2_9_78_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.clim.2009.01.006"},{"key":"e_1_2_9_79_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1399-3038.2011.01241.x"},{"key":"e_1_2_9_80_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jdermsci.2010.08.013"},{"key":"e_1_2_9_81_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1398-9995.2005.00774.x"},{"key":"e_1_2_9_82_1","doi-asserted-by":"publisher","DOI":"10.1136\/ard.2004.032482"},{"key":"e_1_2_9_83_1","doi-asserted-by":"publisher","DOI":"10.1080\/00015550252948130"},{"key":"e_1_2_9_84_1","doi-asserted-by":"publisher","DOI":"10.1186\/s12969-016-0074-8"},{"key":"e_1_2_9_85_1","doi-asserted-by":"publisher","DOI":"10.1038\/ncprheum0987"},{"key":"e_1_2_9_86_1","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0046740"},{"key":"e_1_2_9_87_1","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pgen.1000041"},{"key":"e_1_2_9_88_1","doi-asserted-by":"publisher","DOI":"10.1111\/bjd.12381"},{"key":"e_1_2_9_89_1","doi-asserted-by":"publisher","DOI":"10.1183\/09031936.02.00245802"},{"key":"e_1_2_9_90_1","doi-asserted-by":"publisher","DOI":"10.1002\/ijc.21883"},{"key":"e_1_2_9_91_1","doi-asserted-by":"publisher","DOI":"10.1001\/archderm.141.9.1123"},{"key":"e_1_2_9_92_1","doi-asserted-by":"publisher","DOI":"10.1093\/aje\/kwq004"},{"key":"e_1_2_9_93_1","doi-asserted-by":"publisher","DOI":"10.1093\/aje\/kwq233"},{"key":"e_1_2_9_94_1","doi-asserted-by":"publisher","DOI":"10.1158\/1055-9965.EPI-14-1243"},{"key":"e_1_2_9_95_1","doi-asserted-by":"publisher","DOI":"10.1111\/pde.12665"},{"key":"e_1_2_9_96_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.clim.2006.08.008"},{"key":"e_1_2_9_97_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2133.1974.tb06447.x"},{"key":"e_1_2_9_98_1","doi-asserted-by":"publisher","DOI":"10.2165\/00128071-200607050-00001"},{"key":"e_1_2_9_99_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2133.2010.09743.x"},{"key":"e_1_2_9_100_1","doi-asserted-by":"publisher","DOI":"10.1016\/S1081-1206(10)60859-9"},{"key":"e_1_2_9_101_1","doi-asserted-by":"publisher","DOI":"10.1111\/pde.12786"},{"key":"e_1_2_9_102_1","doi-asserted-by":"publisher","DOI":"10.1111\/1346-8138.12265"},{"key":"e_1_2_9_103_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jaci.2009.05.020"},{"key":"e_1_2_9_104_1","doi-asserted-by":"publisher","DOI":"10.1001\/jamadermatol.2015.3605"},{"key":"e_1_2_9_105_1","doi-asserted-by":"publisher","DOI":"10.1038\/jid.2013.508"},{"key":"e_1_2_9_106_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1742-1241.2006.01047.x"},{"key":"e_1_2_9_107_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jaci.2012.10.041"},{"key":"e_1_2_9_108_1","doi-asserted-by":"publisher","DOI":"10.2340\/00015555-2183"},{"key":"e_1_2_9_109_1","doi-asserted-by":"publisher","DOI":"10.1038\/jid.2014.530"},{"key":"e_1_2_9_110_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1398-9995.2010.02449.x"},{"key":"e_1_2_9_111_1","doi-asserted-by":"crossref","first-page":"2994","DOI":"10.4049\/jimmunol.159.6.2994","volume":"159","author":"Mittleman B. B.","year":"1997","journal-title":"J. Immunol."},{"key":"e_1_2_9_112_1","doi-asserted-by":"publisher","DOI":"10.1067\/mjd.2000.105948"},{"key":"e_1_2_9_113_1","unstructured":"National Institutes of Health Study to compare efficacy and safety of ABP 501 and adalimumab (Humira\u00ae) in adults with moderate to severe plaque psoriasis https:\/\/clinicaltrials.gov\/ct2\/show\/NCT01970488(accessed: 22 April 2016)."},{"key":"e_1_2_9_114_1","unstructured":"US Food and Drug Administration FDA approves INFLECTRA a biosimilar to remicade http:\/\/www.fda.gov\/NewsEvents\/Newsroom\/PressAnnouncements\/ucm494227.htm(accessed: 16 August 2016)."},{"key":"e_1_2_9_115_1","doi-asserted-by":"publisher","DOI":"10.1038\/jid.2015.206"},{"key":"e_1_2_9_116_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jaad.2005.03.013"},{"key":"e_1_2_9_117_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jaad.2004.11.022"},{"key":"e_1_2_9_118_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa1314768"},{"key":"e_1_2_9_119_1","unstructured":"National Institutes of Health Phase 2 study to evaluate the efficacy and safety of tralokinumab in adults with atopic dermatitis (D2213C00001) https:\/\/clinicaltrials.gov\/ct2\/show\/NCT02347176(accessed: 22 April 2016)."},{"key":"e_1_2_9_120_1","unstructured":"National Institutes of Health A study of lebrikizumab in patients with persistent moderate to severe atopic dermatitis https:\/\/clinicaltrials.gov\/ct2\/show\/NCT02340234(accessed: 10 May 2016)."},{"key":"e_1_2_9_121_1","unstructured":"National Institutes of Health A phase 2 study of CIM331 for atopic dermatitis patients https:\/\/clinicaltrials.gov\/ct2\/show\/NCT01986933(accessed: 22 April 2016)."},{"key":"e_1_2_9_122_1","unstructured":"National Institutes of Health To assess the safety and activity of GBR 830 compared to placebo in adult patients with moderate\u2010to\u2010severe atopic dermatitis (AD) https:\/\/clinicaltrials.gov\/ct2\/show\/NCT02683928(accessed: 22 April 2016)."},{"key":"e_1_2_9_123_1","unstructured":"National Institutes of Health Safety study of AMG 157 in healthy subjects and subjects with atopic dermatitis https:\/\/clinicaltrials.gov\/ct2\/show\/NCT00757042(accessed: 10 May 2016)."},{"key":"e_1_2_9_124_1","first-page":"786","volume":"14","author":"McAndrew R.","year":"2015","journal-title":"J. Drugs Dermatol."},{"key":"e_1_2_9_125_1","unstructured":"National Institutes of Health Tofacitinib ointment for atopic dermatitis (atopic eczema) https:\/\/clinicaltrials.gov\/ct2\/show\/NCT02001181(accessed: 25 April 2016)."},{"key":"e_1_2_9_126_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jaad.2015.06.045"},{"key":"e_1_2_9_127_1","doi-asserted-by":"publisher","DOI":"10.1111\/bjd.14403"},{"key":"e_1_2_9_128_1","unstructured":"National Institutes of Health A study of baricitinib (LY3009104) in participants with moderate\u2010to\u2010severe atopic dermatitis https:\/\/clinicaltrials.gov\/ct2\/show\/NCT02576938(accessed: 22 April 2016)."},{"key":"e_1_2_9_129_1","unstructured":"National Institutes of Health Efficacy and safety study of QAW039 in the treatment of patients with moderate to severe atopic dermatitis https:\/\/clinicaltrials.gov\/ct2\/show\/study\/NCT01785602(accessed: 25 April 2016)."},{"key":"e_1_2_9_130_1","doi-asserted-by":"publisher","DOI":"10.1124\/mol.115.101832"},{"key":"e_1_2_9_131_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1398-9995.2005.00791.x"},{"key":"e_1_2_9_132_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jdcr.2014.10.007"},{"key":"e_1_2_9_133_1","unstructured":"National Institutes of Health Pilot study of ustekinumab for subjects with chronic atopic dermatitis https:\/\/clinicaltrials.gov\/ct2\/show\/NCT01806662(accessed: 25 April 2016)."},{"key":"e_1_2_9_134_1","unstructured":"Taltz [package insert] Eli Lilly & Co Indianapolis IN2016."},{"key":"e_1_2_9_135_1","unstructured":"Cosentyx [package insert] Novartis Pharmaceuticals Corp East Hanover NJ2016."},{"key":"e_1_2_9_136_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa1503824"},{"key":"e_1_2_9_137_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jaad.2013.12.036"}],"container-title":["Experimental Dermatology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1111%2Fexd.13336","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/exd.13336","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,9,12]],"date-time":"2023-09-12T14:11:31Z","timestamp":1694527891000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1111\/exd.13336"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2017,5,9]]},"references-count":136,"journal-issue":{"issue":"4","published-print":{"date-parts":[[2018,4]]}},"alternative-id":["10.1111\/exd.13336"],"URL":"https:\/\/doi.org\/10.1111\/exd.13336","archive":["Portico"],"relation":{},"ISSN":["0906-6705","1600-0625"],"issn-type":[{"value":"0906-6705","type":"print"},{"value":"1600-0625","type":"electronic"}],"subject":[],"published":{"date-parts":[[2017,5,9]]}}}