{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,2]],"date-time":"2026-06-02T20:34:15Z","timestamp":1780432455058,"version":"3.54.1"},"reference-count":10,"publisher":"Wiley","issue":"10","license":[{"start":{"date-parts":[[2017,7,10]],"date-time":"2017-07-10T00:00:00Z","timestamp":1499644800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"name":"Interdisciplinary Center for Clinical Research","award":["IZKF\/CTRP 07"],"award-info":[{"award-number":["IZKF\/CTRP 07"]}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Experimental Dermatology"],"published-print":{"date-parts":[[2017,10]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>Prurigo nodularis (<jats:styled-content style=\"fixed-case\">PN<\/jats:styled-content>) is a pruritic condition with altered epidermal neuroanatomy as demonstrated previously. Here we elucidated neuroimmunological mechanisms by combining functional, morphological and gene expression experiments in twelve subjects with <jats:styled-content style=\"fixed-case\">PN<\/jats:styled-content> and eight healthy controls. Subjects with <jats:styled-content style=\"fixed-case\">PN<\/jats:styled-content> showed a reduced intra\u2010epidermal nerve fibre density (<jats:styled-content style=\"fixed-case\">IENFD<\/jats:styled-content>) in lesional skin. Quantitative sensory testing indicated maintenance of somatosensory function compared to controls. None of the tested molecular markers including the neuron\u2010distracting <jats:styled-content style=\"fixed-case\">SEMA<\/jats:styled-content>3A and neuron\u2010attracting <jats:styled-content style=\"fixed-case\">NGF<\/jats:styled-content> were altered in lesional vs non\u2010lesional skin in <jats:styled-content style=\"fixed-case\">PN<\/jats:styled-content> subjects. Accordingly, we speculate that scratching may contribute to reduced <jats:styled-content style=\"fixed-case\">IENFD<\/jats:styled-content> rather than an authentic endogenous neuropathy.<\/jats:p>","DOI":"10.1111\/exd.13343","type":"journal-article","created":{"date-parts":[[2017,3,31]],"date-time":"2017-03-31T07:22:54Z","timestamp":1490944974000},"page":"969-971","source":"Crossref","is-referenced-by-count":44,"title":["There is no functional small\u2010fibre neuropathy in prurigo nodularis despite neuroanatomical alterations"],"prefix":"10.1111","volume":"26","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-5649-2698","authenticated-orcid":false,"given":"Manuel P.","family":"Pereira","sequence":"first","affiliation":[{"name":"Department of Dermatology and Center for Chronic Pruritus University Hospital M\u00fcnster  M\u00fcnster Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Esther","family":"Pogatzki\u2010Zahn","sequence":"additional","affiliation":[{"name":"Department of Anaesthesiology Intensive Care and Pain Medicine University Hospital M\u00fcnster  M\u00fcnster Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Chantal","family":"Snels","sequence":"additional","affiliation":[{"name":"Health, Medical and Neuropsychology Unit Institute of Psychology University of Leiden  Leiden The Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Thai\u2010Ha","family":"Vu","sequence":"additional","affiliation":[{"name":"Department of Dermatology and Center for Chronic Pruritus University Hospital M\u00fcnster  M\u00fcnster Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nurcan","family":"\u00dc\u00e7eyler","sequence":"additional","affiliation":[{"name":"Department of Neurology University of W\u00fcrzburg  W\u00fcrzburg Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Karin","family":"Loser","sequence":"additional","affiliation":[{"name":"Department of Dermatology and Center for Chronic Pruritus University Hospital M\u00fcnster  M\u00fcnster Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Claudia","family":"Sommer","sequence":"additional","affiliation":[{"name":"Department of Neurology University of W\u00fcrzburg  W\u00fcrzburg Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Andrea Walburga Maria","family":"Evers","sequence":"additional","affiliation":[{"name":"Health, Medical and Neuropsychology Unit Institute of Psychology University of Leiden  Leiden The Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Antoinette I. 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