{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,1]],"date-time":"2026-10-01T05:49:32Z","timestamp":1790833772285,"version":"4.1.0"},"reference-count":57,"publisher":"Wiley","issue":"10","license":[{"start":{"date-parts":[[2017,7,3]],"date-time":"2017-07-03T00:00:00Z","timestamp":1499040000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/501100001602","name":"Science Foundation Ireland","doi-asserted-by":"publisher","award":["13\/CDA\/2155"],"award-info":[{"award-number":["13\/CDA\/2155"]}],"id":[{"id":"10.13039\/501100001602","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Experimental Dermatology"],"published-print":{"date-parts":[[2017,10]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>Volatile organic compounds emitted by human skin were sampled before and after acute barrier disruption of the volar forearm to investigate the significance of this approach to skin physiology research. A small wearable housing integrating a solid\u2010phase micro\u2010extraction fibre permitting rapid enclosed headspace sampling of human skin volatiles is presented, enabling non\u2010invasive sample collection in 15\u00a0minutes, in a comfortable wearable format. Gas chromatography\u2010mass spectrometry was utilised to separate and identify the volatile metabolites. A total of 37 compounds were identified, with aldehydes (hexanal, nonanal, decanal), acids (nonanoic, decanoic, dodecanoic, tetradecanoic and pentadecanoic acids) and hydrocarbons (squalane, squalene) predominant within the chemical profile. Acute barrier disruption was achieved through tape stripping (<jats:styled-content style=\"fixed-case\">TS<\/jats:styled-content>) of the stratum corneum to determine the impact on the volatile signature. Principle component analysis demonstrated there to be a discriminating volatile signature before and after <jats:styled-content style=\"fixed-case\">TS<\/jats:styled-content>. The dysregulation of significant features was examined. Several compounds derived from sebaceous components and their oxidation products were altered following barrier disruption, including squalane, squalene, octanal and nonanal. The upregulation of glycine was also observed, which may indicate a perturbation to the skin's natural moisturising factor production. <jats:styled-content style=\"fixed-case\">TS<\/jats:styled-content> impacted the hydro\u2010lipid film that functions within the skin barrier, resulting in a differing volatile signature from affected skin. This provides a valuable non\u2010invasive approach for scientific and clinical studies in dermatology, particularly around dermatological disorders associated with compromised barrier function.<\/jats:p>","DOI":"10.1111\/exd.13344","type":"journal-article","created":{"date-parts":[[2017,3,31]],"date-time":"2017-03-31T07:22:50Z","timestamp":1490944970000},"page":"919-925","source":"Crossref","is-referenced-by-count":35,"title":["Probing skin physiology through the volatile footprint: Discriminating volatile emissions before and after acute barrier disruption"],"prefix":"10.1111","volume":"26","author":[{"given":"Emer","family":"Duffy","sequence":"first","affiliation":[{"name":"School of Chemical Sciences National Centre for Sensor Research Dublin City University  Dublin Ireland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Matthew R.","family":"Jacobs","sequence":"additional","affiliation":[{"name":"School of Chemical Sciences National Centre for Sensor Research Dublin City University  Dublin Ireland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Brian","family":"Kirby","sequence":"additional","affiliation":[{"name":"Dermatology Research Group St. Vincent's University Hospital  Dublin Ireland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-3031-4794","authenticated-orcid":false,"given":"Aoife","family":"Morrin","sequence":"additional","affiliation":[{"name":"School of Chemical Sciences National Centre for Sensor Research Dublin City University  Dublin Ireland"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2017,7,3]]},"reference":[{"key":"e_1_2_8_2_1","doi-asserted-by":"publisher","DOI":"10.1093\/jb\/mvr090"},{"key":"e_1_2_8_3_1","doi-asserted-by":"publisher","DOI":"10.1183\/09031936.00142508"},{"key":"e_1_2_8_4_1","doi-asserted-by":"publisher","DOI":"10.1039\/C3CS60329F"},{"key":"e_1_2_8_5_1","doi-asserted-by":"publisher","DOI":"10.1586\/erm.10.112"},{"key":"e_1_2_8_6_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.healun.2003.07.017"},{"key":"e_1_2_8_7_1","first-page":"1020","volume":"3","author":"Calenic B.","year":"2015","journal-title":"Open Chem."},{"key":"e_1_2_8_8_1","doi-asserted-by":"publisher","DOI":"10.1515\/CCLM.2002.101"},{"key":"e_1_2_8_9_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0891-5849(99)00212-9"},{"key":"e_1_2_8_10_1","doi-asserted-by":"publisher","DOI":"10.1586\/erm.11.31"},{"key":"e_1_2_8_11_1","doi-asserted-by":"publisher","DOI":"10.2116\/analsci.21.1471"},{"key":"e_1_2_8_12_1","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0013813"},{"key":"e_1_2_8_13_1","doi-asserted-by":"publisher","DOI":"10.4172\/1948-5956.1000076"},{"key":"e_1_2_8_14_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jchromb.2013.05.007"},{"key":"e_1_2_8_15_1","doi-asserted-by":"publisher","DOI":"10.1007\/s11306-013-0523-z"},{"key":"e_1_2_8_16_1","doi-asserted-by":"publisher","DOI":"10.1002\/rcm.3402"},{"key":"e_1_2_8_17_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ijms.2006.02.015"},{"key":"e_1_2_8_18_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jchromb.2012.10.028"},{"key":"e_1_2_8_19_1","doi-asserted-by":"publisher","DOI":"10.1016\/B978-0-12-416017-0.00001-2"},{"key":"e_1_2_8_20_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2133.2008.08748.x"},{"key":"e_1_2_8_21_1","doi-asserted-by":"publisher","DOI":"10.1021\/ac990963k"},{"key":"e_1_2_8_22_1","doi-asserted-by":"publisher","DOI":"10.1021\/ac0606204"},{"key":"e_1_2_8_23_1","doi-asserted-by":"publisher","DOI":"10.1098\/rsif.2006.0182"},{"key":"e_1_2_8_24_1","doi-asserted-by":"publisher","DOI":"10.1039\/b802515k"},{"key":"e_1_2_8_25_1","doi-asserted-by":"publisher","DOI":"10.1039\/C4AN00134F"},{"key":"e_1_2_8_26_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jchromb.2005.06.026"},{"key":"e_1_2_8_27_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jchromb.2007.09.033"},{"key":"e_1_2_8_28_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.aca.2013.09.056"},{"key":"e_1_2_8_29_1","doi-asserted-by":"publisher","DOI":"10.1007\/s10886-013-0286-z"},{"key":"e_1_2_8_30_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1524-475X.2010.00592.x"},{"key":"e_1_2_8_31_1","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0069271"},{"key":"e_1_2_8_32_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.chroma.2009.12.052"},{"key":"e_1_2_8_33_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1600-065X.2011.01027.x"},{"key":"e_1_2_8_34_1","doi-asserted-by":"publisher","DOI":"10.1007\/BF00371571"},{"key":"e_1_2_8_35_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.0022-202X.2005.23668.x"},{"key":"e_1_2_8_36_1","doi-asserted-by":"publisher","DOI":"10.1111\/srt.12028"},{"key":"e_1_2_8_37_1","doi-asserted-by":"publisher","DOI":"10.1007\/s10886-005-5801-4"},{"key":"e_1_2_8_38_1","first-page":"81","volume":"1","author":"Prada P. A.","year":"2008","journal-title":"Rev. Cien. Foren."},{"key":"e_1_2_8_39_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1556-4029.2009.01236.x"},{"key":"e_1_2_8_40_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1556-4029.2012.02215.x"},{"key":"e_1_2_8_41_1","doi-asserted-by":"publisher","DOI":"10.1186\/1471-2105-11-405"},{"key":"e_1_2_8_42_1","doi-asserted-by":"publisher","DOI":"10.1021\/ac300698c"},{"key":"e_1_2_8_43_1","doi-asserted-by":"publisher","DOI":"10.1021\/ac3029745"},{"key":"e_1_2_8_44_1","volume-title":"Cosmetic and Toiletry Formulations","author":"Flick E. W.","year":"2001"},{"key":"e_1_2_8_45_1","doi-asserted-by":"publisher","DOI":"10.4161\/derm.1.2.7811"},{"key":"e_1_2_8_46_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1574-6941.2010.00908.x"},{"key":"e_1_2_8_47_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.foodchem.2011.02.063"},{"key":"e_1_2_8_48_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0022-2275(20)37014-0"},{"key":"e_1_2_8_49_1","doi-asserted-by":"crossref","first-page":"563","DOI":"10.1016\/S0022-2275(20)36757-2","volume":"15","author":"Nikkari T.","year":"1974","journal-title":"J. Lipid Res."},{"key":"e_1_2_8_50_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jchromb.2014.04.006"},{"key":"e_1_2_8_51_1","doi-asserted-by":"publisher","DOI":"10.1046\/j.0022-202x.2001.01287.x"},{"key":"e_1_2_8_52_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2133.2004.06084.x"},{"key":"e_1_2_8_53_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ejpb.2008.08.008"},{"key":"e_1_2_8_54_1","doi-asserted-by":"publisher","DOI":"10.1067\/mjd.2003.105"},{"key":"e_1_2_8_55_1","first-page":"29","volume-title":"Current Problems in Dermatology","author":"Thiele J. J.","year":"2001"},{"key":"e_1_2_8_56_1","doi-asserted-by":"publisher","DOI":"10.1111\/ics.12019"},{"key":"e_1_2_8_57_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1396-0296.2004.04S1005.x"},{"key":"e_1_2_8_58_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1600-0625.2012.01545.x"}],"container-title":["Experimental Dermatology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1111%2Fexd.13344","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/exd.13344","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,9,24]],"date-time":"2023-09-24T14:18:03Z","timestamp":1695565083000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1111\/exd.13344"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2017,7,3]]},"references-count":57,"journal-issue":{"issue":"10","published-print":{"date-parts":[[2017,10]]}},"alternative-id":["10.1111\/exd.13344"],"URL":"https:\/\/doi.org\/10.1111\/exd.13344","archive":["Portico"],"relation":{},"ISSN":["0906-6705","1600-0625"],"issn-type":[{"value":"0906-6705","type":"print"},{"value":"1600-0625","type":"electronic"}],"subject":[],"published":{"date-parts":[[2017,7,3]]}}}