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As both the incidence of the disease and the relative proportion of the elderly population continue to rise, it represents a significant medical burden. Whereas some progress has been achieved in defining genetic risk factors for autoimmune blistering diseases, no environmental agent has been conclusively identified. Emerging evidence suggests that host immunity may influence the skin microbiota, while the latter modulates cutaneous immunity. Nevertheless, the relationship between skin microbial communities and autoimmune bullous disease has yet to be studied in humans. Here, we aim to characterise and compare the skin microbiome of patients with<jats:styled-content style=\"fixed-case\">BP<\/jats:styled-content>and healthy, age\u2010matched controls at numerous body sites. Similar to what has been shown in healthy controls, the composition of skin microbiota in patients with<jats:styled-content style=\"fixed-case\">BP<\/jats:styled-content>appears to be very divergent and site specific. Microbial phylum abundances differ between perilesional sites of patients with<jats:styled-content style=\"fixed-case\">BP<\/jats:styled-content>and the same anatomic locations of control patients. A distinct cutaneous microbiota profile, which correlates with<jats:styled-content style=\"fixed-case\">BP<\/jats:styled-content>, further strengthens the significance of commensal\u2010host interaction on our immune system. Moreover, these results raise the possibility that the cutaneous microbiome may contribute to the pathogenesis of<jats:styled-content style=\"fixed-case\">BP<\/jats:styled-content>, with important implications for the treatment of this disease.<\/jats:p>","DOI":"10.1111\/exd.13357","type":"journal-article","created":{"date-parts":[[2017,4,18]],"date-time":"2017-04-18T13:57:22Z","timestamp":1492523842000},"page":"1221-1227","source":"Crossref","is-referenced-by-count":33,"title":["A distinct cutaneous microbiota profile in autoimmune bullous disease patients"],"prefix":"10.1111","volume":"26","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-8027-4631","authenticated-orcid":false,"given":"Mor","family":"Miodovnik","sequence":"first","affiliation":[{"name":"Department of Dermatology Tel Aviv Sourasky Medical Center Tel Aviv Israel"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Axel","family":"K\u00fcnstner","sequence":"additional","affiliation":[{"name":"L\u00fcbeck Institute of Experimental Dermatology (LIED) University of L\u00fcbeck L\u00fcbeck Germany"},{"name":"Max Planck Institute for Evolutionary Biology Pl\u00f6n Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ewan A.","family":"Langan","sequence":"additional","affiliation":[{"name":"Institute of Medical Microbiology und Hygiene University of L\u00fcbeck L\u00fcbeck Germany"},{"name":"Department of Dermatological Science Division of Musculoskeletal &amp; 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