{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,2,27]],"date-time":"2026-02-27T02:45:06Z","timestamp":1772160306168,"version":"3.50.1"},"reference-count":60,"publisher":"Wiley","issue":"12","license":[{"start":{"date-parts":[[2017,8,29]],"date-time":"2017-08-29T00:00:00Z","timestamp":1503964800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Experimental Dermatology"],"published-print":{"date-parts":[[2017,12]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:p>Bullous pemphigoid (BP) is an autoimmune subepidermal blistering disease that clinically demonstrates tense blisters with widespread erythema, histologically demonstrates subepidermal blistering and immunologically demonstrates the presence of circulating autoantibodies against hemidesmosomal molecules. Complement activation has long been regarded as necessary for the generation of the BP. However, certain evidence has recently come to support non\u2010complemental blistering mechanisms. The story of BP blistering mechanisms is a complicated one. This review mainly focuses on a specific blistering mechanism that highlights the role of complements in BP blistering.<\/jats:p>","DOI":"10.1111\/exd.13367","type":"journal-article","created":{"date-parts":[[2017,4,18]],"date-time":"2017-04-18T09:42:22Z","timestamp":1492508542000},"page":"1235-1239","source":"Crossref","is-referenced-by-count":25,"title":["Complement\u2010independent blistering mechanisms in bullous pemphigoid"],"prefix":"10.1111","volume":"26","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-8781-2735","authenticated-orcid":false,"given":"Hiroaki","family":"Iwata","sequence":"first","affiliation":[{"name":"Department of Dermatology Hokkaido University Graduate School of Medicine Sapporo Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Hideyuki","family":"Ujiie","sequence":"additional","affiliation":[{"name":"Department of Dermatology Hokkaido University Graduate School of Medicine Sapporo Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2017,8,29]]},"reference":[{"key":"e_1_2_10_2_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(12)61140-4"},{"key":"e_1_2_10_3_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.clim.2008.04.012"},{"key":"e_1_2_10_4_1","doi-asserted-by":"publisher","DOI":"10.1172\/JCI114812"},{"key":"e_1_2_10_5_1","doi-asserted-by":"publisher","DOI":"10.1111\/1523-1747.ep12616580"},{"key":"e_1_2_10_6_1","doi-asserted-by":"publisher","DOI":"10.1016\/0092-8674(81)90115-X"},{"key":"e_1_2_10_7_1","doi-asserted-by":"publisher","DOI":"10.1111\/1523-1747.ep12876200"},{"key":"e_1_2_10_8_1","doi-asserted-by":"crossref","first-page":"17784","DOI":"10.1016\/S0021-9258(18)55195-4","volume":"266","author":"Sawamura D.","year":"1991","journal-title":"J. Biol. Chem."},{"key":"e_1_2_10_9_1","doi-asserted-by":"publisher","DOI":"10.1111\/1523-1747.ep12484863"},{"key":"e_1_2_10_10_1","doi-asserted-by":"publisher","DOI":"10.1172\/JCI117826"},{"key":"e_1_2_10_11_1","doi-asserted-by":"publisher","DOI":"10.1172\/JCI17891"},{"key":"e_1_2_10_12_1","doi-asserted-by":"publisher","DOI":"10.1172\/JCI119639"},{"key":"e_1_2_10_13_1","doi-asserted-by":"publisher","DOI":"10.1172\/JCI11494"},{"key":"e_1_2_10_14_1","first-page":"897","volume":"148","author":"Borrego L.","year":"1996","journal-title":"Am. J. Pathol."},{"key":"e_1_2_10_15_1","doi-asserted-by":"publisher","DOI":"10.4049\/jimmunol.1100596"},{"key":"e_1_2_10_16_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ajpath.2014.05.007"},{"key":"e_1_2_10_17_1","doi-asserted-by":"publisher","DOI":"10.1074\/jbc.M111.221036"},{"key":"e_1_2_10_18_1","doi-asserted-by":"publisher","DOI":"10.1016\/0190-9622(92)70235-8"},{"key":"e_1_2_10_19_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jid.2016.06.622"},{"key":"e_1_2_10_20_1","doi-asserted-by":"publisher","DOI":"10.1001\/archderm.136.2.174"},{"key":"e_1_2_10_21_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0923-1811(02)00109-3"},{"key":"e_1_2_10_22_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2133.2004.06082.x"},{"key":"e_1_2_10_23_1","doi-asserted-by":"crossref","first-page":"8825","DOI":"10.1016\/S0021-9258(18)52948-3","volume":"268","author":"Li K.","year":"1993","journal-title":"J. Biol. Chem."},{"key":"e_1_2_10_24_1","doi-asserted-by":"publisher","DOI":"10.3181\/00379727-136-35421"},{"key":"e_1_2_10_25_1","doi-asserted-by":"publisher","DOI":"10.1038\/nm1496"},{"key":"e_1_2_10_26_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jaut.2008.08.009"},{"key":"e_1_2_10_27_1","doi-asserted-by":"publisher","DOI":"10.4049\/jimmunol.0903101"},{"key":"e_1_2_10_28_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jdermsci.2015.01.013"},{"key":"e_1_2_10_29_1","doi-asserted-by":"publisher","DOI":"10.1111\/bjd.14822"},{"key":"e_1_2_10_30_1","doi-asserted-by":"publisher","DOI":"10.1172\/JCI116856"},{"key":"e_1_2_10_31_1","doi-asserted-by":"publisher","DOI":"10.4049\/jimmunol.1000667"},{"key":"e_1_2_10_32_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2133.1991.tb00579.x"},{"key":"e_1_2_10_33_1","doi-asserted-by":"publisher","DOI":"10.1111\/1523-1747.ep12371702"},{"key":"e_1_2_10_34_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-4632.2007.03396.x"},{"key":"e_1_2_10_35_1","doi-asserted-by":"publisher","DOI":"10.1111\/1523-1747.ep12537474"},{"key":"e_1_2_10_36_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2133.1978.tb02016.x"},{"key":"e_1_2_10_37_1","doi-asserted-by":"crossref","first-page":"1273","DOI":"10.4049\/jimmunol.141.4.1273","volume":"141","author":"Basset\u2010Seguin N.","year":"1988","journal-title":"J. Immunol."},{"key":"e_1_2_10_38_1","doi-asserted-by":"publisher","DOI":"10.1002\/jcla.1860030509"},{"key":"e_1_2_10_39_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1346-8138.1990.tb03008.x"},{"key":"e_1_2_10_40_1","doi-asserted-by":"publisher","DOI":"10.1111\/bjd.14411"},{"key":"e_1_2_10_41_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jaci.2009.09.046"},{"key":"e_1_2_10_42_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jaut.2016.06.019"},{"key":"e_1_2_10_43_1","doi-asserted-by":"crossref","first-page":"4470","DOI":"10.1002\/j.1460-2075.1995.tb00126.x","volume":"14","author":"Mainiero F.","year":"1995","journal-title":"EMBO J."},{"key":"e_1_2_10_44_1","doi-asserted-by":"publisher","DOI":"10.1093\/emboj\/16.9.2365"},{"key":"e_1_2_10_45_1","doi-asserted-by":"publisher","DOI":"10.1111\/exd.12146"},{"key":"e_1_2_10_46_1","doi-asserted-by":"publisher","DOI":"10.1111\/exd.12939"},{"key":"e_1_2_10_47_1","doi-asserted-by":"publisher","DOI":"10.1016\/0014-4827(92)90034-6"},{"key":"e_1_2_10_48_1","doi-asserted-by":"publisher","DOI":"10.1159\/000246928"},{"key":"e_1_2_10_49_1","doi-asserted-by":"publisher","DOI":"10.1111\/1523-1747.ep12470554"},{"key":"e_1_2_10_50_1","doi-asserted-by":"publisher","DOI":"10.1046\/j.1365-2133.1998.02028.x"},{"key":"e_1_2_10_51_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1346-8138.1994.tb03299.x"},{"key":"e_1_2_10_52_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jid.2015.11.030"},{"key":"e_1_2_10_53_1","doi-asserted-by":"publisher","DOI":"10.1038\/labinvest.2016.108"},{"key":"e_1_2_10_54_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ajpath.2012.11.029"},{"key":"e_1_2_10_55_1","doi-asserted-by":"publisher","DOI":"10.1038\/jid.2008.305"},{"key":"e_1_2_10_56_1","doi-asserted-by":"publisher","DOI":"10.1111\/exd.13331"},{"key":"e_1_2_10_57_1","doi-asserted-by":"publisher","DOI":"10.4049\/jimmunol.1003402"},{"key":"e_1_2_10_58_1","doi-asserted-by":"publisher","DOI":"10.4049\/jimmunol.1400095"},{"key":"e_1_2_10_59_1","doi-asserted-by":"publisher","DOI":"10.1038\/nri1266"},{"key":"e_1_2_10_60_1","doi-asserted-by":"publisher","DOI":"10.1084\/jem.178.2.661"},{"key":"e_1_2_10_61_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jaad.2014.01.903"}],"container-title":["Experimental Dermatology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1111%2Fexd.13367","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/exd.13367","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,9,13]],"date-time":"2023-09-13T08:41:07Z","timestamp":1694594467000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1111\/exd.13367"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2017,8,29]]},"references-count":60,"journal-issue":{"issue":"12","published-print":{"date-parts":[[2017,12]]}},"alternative-id":["10.1111\/exd.13367"],"URL":"https:\/\/doi.org\/10.1111\/exd.13367","archive":["Portico"],"relation":{"has-review":[{"id-type":"doi","id":"10.3410\/f.727521950.793549772","asserted-by":"object"}]},"ISSN":["0906-6705","1600-0625"],"issn-type":[{"value":"0906-6705","type":"print"},{"value":"1600-0625","type":"electronic"}],"subject":[],"published":{"date-parts":[[2017,8,29]]}}}