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Adequate animal models for <jats:styled-content style=\"fixed-case\">AA<\/jats:styled-content> are currently lacking. The objective of this study was to elucidate the mechanism of autoimmune\u2010like alopecia (<jats:styled-content style=\"fixed-case\">ALA<\/jats:styled-content>) in C57<jats:styled-content style=\"fixed-case\">BL<\/jats:styled-content>\/6.<jats:styled-content style=\"fixed-case\">CD<\/jats:styled-content>80<jats:styled-content style=\"fixed-case\">CD<\/jats:styled-content>86\u2010deficient (B6.<jats:styled-content style=\"fixed-case\">CD<\/jats:styled-content>80<jats:styled-content style=\"fixed-case\">CD<\/jats:styled-content>86<jats:sup>\u2212\/\u2212<\/jats:sup>) mice. Incidence and severity of alopecia were analysed in 58 B6.<jats:styled-content style=\"fixed-case\">CD<\/jats:styled-content>80<jats:styled-content style=\"fixed-case\">CD<\/jats:styled-content>86<jats:sup>\u2212\/\u2212<\/jats:sup> mice using histological examination, flow cytometry, multiplex enzyme\u2010linked immunosorbent assay, quantitative <jats:styled-content style=\"fixed-case\">RT<\/jats:styled-content>\u2010<jats:styled-content style=\"fixed-case\">PCR<\/jats:styled-content> and <jats:styled-content style=\"fixed-case\">CD<\/jats:styled-content>25 inhibition test. Both male and female B6.<jats:styled-content style=\"fixed-case\">CD<\/jats:styled-content>80<jats:styled-content style=\"fixed-case\">CD<\/jats:styled-content>86<jats:sup>\u2212\/\u2212<\/jats:sup> mice showed almost 100% incidence of hair loss at 40 weeks of age. Moreover, <jats:styled-content style=\"fixed-case\">CD<\/jats:styled-content>4+FoxP3+Treg (Treg) cell population in B6.<jats:styled-content style=\"fixed-case\">CD<\/jats:styled-content>80<jats:styled-content style=\"fixed-case\">CD<\/jats:styled-content>86<jats:sup>\u2212\/\u2212<\/jats:sup> mice was significantly lower than in B6 mice, which presumably underlined autoimmune reaction. Histologically, B6.<jats:styled-content style=\"fixed-case\">CD<\/jats:styled-content>80<jats:styled-content style=\"fixed-case\">CD<\/jats:styled-content>86<jats:sup>\u2212\/\u2212<\/jats:sup> mice showed <jats:styled-content style=\"fixed-case\">CD<\/jats:styled-content>4+ and <jats:styled-content style=\"fixed-case\">CD<\/jats:styled-content>8+ T\u2010cell infiltration around terminal follicle region and exhibited hair follicle destruction in the anagen or catagen stage. Negative correlation between the number of <jats:styled-content style=\"fixed-case\">CD<\/jats:styled-content>4+FoxP3+ Tregs and <jats:styled-content style=\"fixed-case\">ALA<\/jats:styled-content> was confirmed by the <jats:styled-content style=\"fixed-case\">CD<\/jats:styled-content>25 depletion test in B6 mice, as follicle destruction was similar to that observed in B6.<jats:styled-content style=\"fixed-case\">CD<\/jats:styled-content>80<jats:styled-content style=\"fixed-case\">CD<\/jats:styled-content>86<jats:sup>\u2212\/\u2212<\/jats:sup> animals. <jats:styled-content style=\"fixed-case\">CD<\/jats:styled-content>80<jats:styled-content style=\"fixed-case\">CD<\/jats:styled-content>86 deficiency disrupted <jats:styled-content style=\"fixed-case\">CD<\/jats:styled-content>4+FoxP3+ Treg homoeostasis and prompted the development of <jats:styled-content style=\"fixed-case\">ALA<\/jats:styled-content>. We demonstrated that B6.<jats:styled-content style=\"fixed-case\">CD<\/jats:styled-content>80<jats:styled-content style=\"fixed-case\">CD<\/jats:styled-content>86<jats:sup>\u2212\/\u2212<\/jats:sup> mice might have several advantages as an <jats:styled-content style=\"fixed-case\">ALA<\/jats:styled-content> model, because they exhibited high incidence of disease phenotype and epipathogenesis similar to that observed in human <jats:styled-content style=\"fixed-case\">AA<\/jats:styled-content>.<\/jats:p>","DOI":"10.1111\/exd.13371","type":"journal-article","created":{"date-parts":[[2017,4,19]],"date-time":"2017-04-19T16:28:36Z","timestamp":1492619316000},"page":"1053-1059","source":"Crossref","is-referenced-by-count":9,"title":["<scp>CD<\/scp>80<scp>CD<\/scp>86 deficiency disrupts regulatory <scp>CD<\/scp>4+FoxP3+T cell homoeostasis and induces autoimmune\u2010like alopecia"],"prefix":"10.1111","volume":"26","author":[{"given":"Ji\u2010Hyun","family":"Bae","sequence":"first","affiliation":[{"name":"Designed Animal and Transplantation Research Institute Greenbio Research and Technology Seoul National University  Pyeongchang Kangwon Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Woo\u2010Sung","family":"Hwang","sequence":"additional","affiliation":[{"name":"Designed Animal and Transplantation Research Institute Greenbio Research and Technology Seoul National University  Pyeongchang Kangwon Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yoo\u2010Jin","family":"Jang","sequence":"additional","affiliation":[{"name":"Graduate School of International Agricultural Technology Seoul National University  Pyeongchang Kangwon Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yoon\u2010Hoo","family":"Lee","sequence":"additional","affiliation":[{"name":"Graduate School of International Agricultural Technology Seoul National University  Pyeongchang Kangwon Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Da\u2010Eun","family":"Jang","sequence":"additional","affiliation":[{"name":"Graduate School of International Agricultural Technology Seoul National University  Pyeongchang Kangwon Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jung\u2010Sik","family":"Kim","sequence":"additional","affiliation":[{"name":"Institute of Endemic Diseases Seoul National University College of Medicine  Seoul Korea"},{"name":"Xenotransplantation Research Center Seoul National University  Chongno Seol Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-9491-5740","authenticated-orcid":false,"given":"Su\u2010Cheong","family":"Yeom","sequence":"additional","affiliation":[{"name":"Designed Animal and Transplantation Research Institute Greenbio Research and Technology Seoul National University  Pyeongchang Kangwon Korea"},{"name":"Graduate School of International Agricultural Technology Seoul National University  Pyeongchang Kangwon Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2017,7,3]]},"reference":[{"key":"e_1_2_8_2_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.autrev.2014.10.014"},{"key":"e_1_2_8_3_1","doi-asserted-by":"publisher","DOI":"10.1038\/nrdp.2017.11"},{"key":"e_1_2_8_4_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1529-8019.2011.01414.x"},{"key":"e_1_2_8_5_1","doi-asserted-by":"publisher","DOI":"10.1038\/sj.jid.5701183"},{"key":"e_1_2_8_6_1","doi-asserted-by":"publisher","DOI":"10.1172\/JCI31942"},{"key":"e_1_2_8_7_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.autrev.2016.03.008"},{"key":"e_1_2_8_8_1","doi-asserted-by":"publisher","DOI":"10.1155\/2015\/351732"},{"key":"e_1_2_8_9_1","doi-asserted-by":"publisher","DOI":"10.1111\/bjd.12396"},{"key":"e_1_2_8_10_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jdermsci.2013.01.006"},{"key":"e_1_2_8_11_1","doi-asserted-by":"publisher","DOI":"10.1111\/1523-1747.ep12382416"},{"key":"e_1_2_8_12_1","doi-asserted-by":"publisher","DOI":"10.1046\/j.1523-1747.2002.01745.x"},{"key":"e_1_2_8_13_1","doi-asserted-by":"publisher","DOI":"10.1016\/S1074-7613(00)80195-8"},{"key":"e_1_2_8_14_1","doi-asserted-by":"publisher","DOI":"10.4049\/jimmunol.1301424"},{"key":"e_1_2_8_15_1","doi-asserted-by":"publisher","DOI":"10.2337\/db13-1094"},{"key":"e_1_2_8_16_1","doi-asserted-by":"publisher","DOI":"10.1172\/JCI200420483"},{"key":"e_1_2_8_17_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.trim.2008.09.009"},{"key":"e_1_2_8_18_1","doi-asserted-by":"publisher","DOI":"10.4049\/jimmunol.1100657"},{"key":"e_1_2_8_19_1","doi-asserted-by":"publisher","DOI":"10.1093\/nar\/gkp1005"},{"key":"e_1_2_8_20_1","first-page":"191","volume":"20","author":"Alzolibani A. 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