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Researchers have revealed that stress could indeed inhibit hair growth in vivo, but the relationship between chronic stress and melanogenesis remains unknown. In this study, we established two types of stress models, chronic restraint stress (<jats:styled-content style=\"fixed-case\">CRS<\/jats:styled-content>) and chronic unpredicted mild stress (<jats:styled-content style=\"fixed-case\">CUMS<\/jats:styled-content>) mice models, and explored the possible role of stress in mice hair follicle melanogenesis. We found that stress changed hippocampal morphology, decreased 5\u2010<jats:styled-content style=\"fixed-case\">HT<\/jats:styled-content> level in brain and skin and down\u2010regulated 5\u2010<jats:styled-content style=\"fixed-case\">HT<\/jats:styled-content>1A receptor expression in hippocampal <jats:styled-content style=\"fixed-case\">CA<\/jats:styled-content>1 region and skin. The alterations of 5\u2010<jats:styled-content style=\"fixed-case\">HT<\/jats:styled-content> and 5\u2010<jats:styled-content style=\"fixed-case\">HT<\/jats:styled-content>1A receptor might be a threshold of central stress to associate with the behaviour changes. Both two stresses caused cellular damage of melanocytes and inhibition of keratinocytes proliferation in <jats:styled-content style=\"fixed-case\">HF<\/jats:styled-content>, which made the synthetic pigment loss. <jats:styled-content style=\"fixed-case\">CRS<\/jats:styled-content> which was considered primarily as a \u201cpsychological\u201d stressor had the lower melanin production in <jats:styled-content style=\"fixed-case\">HF<\/jats:styled-content>, as well as the level of 5\u2010<jats:styled-content style=\"fixed-case\">HT<\/jats:styled-content> in skin was down\u2010regulated more than those in <jats:styled-content style=\"fixed-case\">CUMS<\/jats:styled-content> group.<\/jats:p>","DOI":"10.1111\/exd.13380","type":"journal-article","created":{"date-parts":[[2017,5,8]],"date-time":"2017-05-08T10:18:43Z","timestamp":1494238723000},"page":"1083-1090","source":"Crossref","is-referenced-by-count":19,"title":["Effects of two chronic stresses on mental state and hair follicle melanogenesis in mice"],"prefix":"10.1111","volume":"26","author":[{"given":"Sha","family":"Liao","sequence":"first","affiliation":[{"name":"State Key Laboratory of Natural Medicines and Jiangsu Key Laboratory of TCM Evaluation and Translational Research China Pharmaceutical University  Nanjing China"},{"name":"Key Laboratory of Resource Biology and Biotechnology in Western China Ministry of Education Northwest University  Xi'an China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-3573-3357","authenticated-orcid":false,"given":"Jinpeng","family":"Lv","sequence":"additional","affiliation":[{"name":"State Key Laboratory of Natural Medicines and Jiangsu Key Laboratory of TCM Evaluation and Translational Research China Pharmaceutical University  Nanjing China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jia","family":"Zhou","sequence":"additional","affiliation":[{"name":"State Key Laboratory of Natural Medicines and Jiangsu Key Laboratory of TCM Evaluation and Translational Research China Pharmaceutical University  Nanjing China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Praveen Kumar","family":"Kalavagunta","sequence":"additional","affiliation":[{"name":"State Key Laboratory of Natural Medicines and Jiangsu Key Laboratory of TCM Evaluation and Translational Research China Pharmaceutical University  Nanjing China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jing","family":"Shang","sequence":"additional","affiliation":[{"name":"State Key Laboratory of Natural Medicines and Jiangsu Key Laboratory of TCM Evaluation and Translational Research China Pharmaceutical University  Nanjing China"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2017,8,14]]},"reference":[{"key":"e_1_2_8_2_1","doi-asserted-by":"publisher","DOI":"10.1038\/sj.jid.5700104"},{"key":"e_1_2_8_3_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.it.2005.10.002"},{"key":"e_1_2_8_4_1","doi-asserted-by":"publisher","DOI":"10.1096\/fj.00-0699fje"},{"key":"e_1_2_8_5_1","doi-asserted-by":"publisher","DOI":"10.1096\/fj.05-4039fje"},{"key":"e_1_2_8_6_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.neubiorev.2004.08.009"},{"key":"e_1_2_8_7_1","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0067395"},{"key":"e_1_2_8_8_1","doi-asserted-by":"publisher","DOI":"10.3109\/09638237.2013.815333"},{"key":"e_1_2_8_9_1","first-page":"619","volume":"48","author":"Hamon M.","year":"2000","journal-title":"Pathol. 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