{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,27]],"date-time":"2026-09-27T23:53:15Z","timestamp":1790553195236,"version":"4.1.0"},"reference-count":9,"publisher":"Wiley","issue":"11","license":[{"start":{"date-parts":[[2017,8,15]],"date-time":"2017-08-15T00:00:00Z","timestamp":1502755200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/501100004085","name":"Ministry of Education, Science and Technology","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100004085","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100002648","name":"Catholic University of Korea","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100002648","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Experimental Dermatology"],"published-print":{"date-parts":[[2017,11]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>Brimonidine is a highly selective \u03b12\u2010adrenergic receptor agonist approved by the <jats:styled-content style=\"fixed-case\">FDA<\/jats:styled-content> for the treatment of rosacea. Rosacea is a major clinical disease with vasodilatation and rash on the centre of the face, and that brimonidine as a vasoconstrictor can act as a remedy for rosacea. However, there is no study of how brimonidine has an effect on rosacea\u2010related immune cells or mechanisms in the skin to improve rosacea. In this study, we observed that clinical features of rosacea induced by <jats:styled-content style=\"fixed-case\">LL<\/jats:styled-content>\u201037 in Balb\/c mice were improved after the application of brimonidine gel, and we also showed a marked decrease in the number of inflammatory cells, especially mast cells (<jats:styled-content style=\"fixed-case\">MC<\/jats:styled-content>s) histologically. Furthermore, we confirmed that <jats:styled-content style=\"fixed-case\">mRNA<\/jats:styled-content> levels of <jats:styled-content style=\"fixed-case\">MC<\/jats:styled-content> enzymes increased by <jats:styled-content style=\"fixed-case\">LL<\/jats:styled-content>\u201037 were reduced by brimonidine gel. To our knowledge, we first found that brimonidine has a mechanism of treating rosacea by reducing the number and <jats:styled-content style=\"fixed-case\">mRNA<\/jats:styled-content> levels of <jats:styled-content style=\"fixed-case\">MC<\/jats:styled-content>\u2010specific enzymes, an important immune cell in the pathogenesis of rosacea.<\/jats:p>","DOI":"10.1111\/exd.13381","type":"journal-article","created":{"date-parts":[[2017,5,13]],"date-time":"2017-05-13T08:05:50Z","timestamp":1494662750000},"page":"1143-1145","source":"Crossref","is-referenced-by-count":27,"title":["Inhibition of mast cell infiltration in an <scp>LL<\/scp>\u201037\u2010induced rosacea mouse model using topical brimonidine tartrate 0.33% gel"],"prefix":"10.1111","volume":"26","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-5167-3449","authenticated-orcid":false,"given":"Miri","family":"Kim","sequence":"first","affiliation":[{"name":"Department of Dermatology Yeouido St. Mary's Hospital The Catholic University of Korea  Seoul Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jongsic","family":"Kim","sequence":"additional","affiliation":[{"name":"Department of Dermatology Yeouido St. Mary's Hospital The Catholic University of Korea  Seoul Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Seo\u2010won","family":"Jeong","sequence":"additional","affiliation":[{"name":"Department of Dermatology Yeouido St. Mary's Hospital The Catholic University of Korea  Seoul Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hyunmu","family":"Jo","sequence":"additional","affiliation":[{"name":"Department of Dermatology Yeouido St. Mary's Hospital The Catholic University of Korea  Seoul Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-2903-9534","authenticated-orcid":false,"given":"Yu Ri","family":"Woo","sequence":"additional","affiliation":[{"name":"Department of Dermatology Yeouido St. Mary's Hospital The Catholic University of Korea  Seoul Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hyun Jeong","family":"Park","sequence":"additional","affiliation":[{"name":"Department of Dermatology Yeouido St. Mary's Hospital The Catholic University of Korea  Seoul Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2017,8,15]]},"reference":[{"key":"e_1_2_2_2_1","doi-asserted-by":"publisher","DOI":"10.1111\/exd.12745"},{"key":"e_1_2_2_3_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2133.2011.10716.x"},{"key":"e_1_2_2_4_1","doi-asserted-by":"crossref","unstructured":"A. M.Layton M.Schaller B.Homey M. A.Hofmann A. P.Bewley P.Lehmann C.Nohlgard D. B.Sarwer N.Kerrouche Y. M.Ma J. Eur. Acad. Dermatol. Venereol.2015 29 2405.","DOI":"10.1111\/jdv.13305"},{"key":"e_1_2_2_5_1","doi-asserted-by":"publisher","DOI":"10.1038\/jid.2014.222"},{"key":"e_1_2_2_6_1","doi-asserted-by":"crossref","unstructured":"R. A.Dorschner M. R.Williams R. L.Gallo Br. J. Dermatol.2014 171 1282.","DOI":"10.1111\/bjd.13446"},{"key":"e_1_2_2_7_1","doi-asserted-by":"crossref","unstructured":"G. H.Caughey Immunol. Rev.2007 217 141.","DOI":"10.1111\/j.1600-065X.2007.00509.x"},{"key":"e_1_2_2_8_1","doi-asserted-by":"crossref","unstructured":"Y. R.Helfrich L. E.Maier Y.Cui G. J.Fisher H.Chubb S.Fligiel D.Sachs J.Varani J.Voorhees JAMA Dermatol2015 151 825.","DOI":"10.1001\/jamadermatol.2014.4728"},{"key":"e_1_2_2_9_1","doi-asserted-by":"crossref","unstructured":"E.Tchougounova A.Lundequist I.Fajardo J. O.Winberg M.Abrink G.Pejler J. Biol. Chem.2005 280 9291.","DOI":"10.1074\/jbc.M410396200"},{"key":"e_1_2_2_10_1","doi-asserted-by":"crossref","unstructured":"A. M.Two W.Wu R. L.Gallo T. R.Hata J. Am. Acad. Dermatol.2015 72 761; quiz 771\u2010762.","DOI":"10.1016\/j.jaad.2014.08.027"}],"container-title":["Experimental Dermatology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1111%2Fexd.13381","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/exd.13381","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,9,23]],"date-time":"2023-09-23T23:59:13Z","timestamp":1695513553000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1111\/exd.13381"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2017,8,15]]},"references-count":9,"journal-issue":{"issue":"11","published-print":{"date-parts":[[2017,11]]}},"alternative-id":["10.1111\/exd.13381"],"URL":"https:\/\/doi.org\/10.1111\/exd.13381","archive":["Portico"],"relation":{},"ISSN":["0906-6705","1600-0625"],"issn-type":[{"value":"0906-6705","type":"print"},{"value":"1600-0625","type":"electronic"}],"subject":[],"published":{"date-parts":[[2017,8,15]]}}}