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In contrast to previous reports commonly focusing on limited molecular and cellular phenotypes of the disease, the aim of this study was to investigate a broad spectrum of markers of cellular immune activation in patients with BP. We found that serum levels of soluble CD4, myeloperoxidase, S100A12, eosinophil cationic protein and soluble P\u2010selectin were significantly elevated in patients with active BP compared with normal controls. Mast cell tryptase and neopterin serum levels significantly decreased at the time of clinical remission of the patients. Additionally, serum concentrations of soluble IL\u20102 receptor, mast cell tryptase and soluble P\u2010selectin were significantly associated with levels of circulating anti\u2010BP180 autoantibodies. Our findings confirm and extend previous reports suggesting some concomitant involvement of a panel of molecules representative for a wide spectrum of cellular players (T cells, mast cells, neutrophils, eosinophils, macrophages and platelets) orchestrating the inflammatory reaction in BP. These data may favour the employment of broad\u2010spectrum or combined immunosuppressants, potentially together with an anticoagulant treatment, over cell\u2010 or molecule\u2010specific targeted therapy in patients with this disorder.<\/jats:p>","DOI":"10.1111\/exd.13382","type":"journal-article","created":{"date-parts":[[2017,5,13]],"date-time":"2017-05-13T08:16:15Z","timestamp":1494663375000},"page":"1248-1252","source":"Crossref","is-referenced-by-count":34,"title":["Analysis of serum markers of cellular immune activation in patients with bullous pemphigoid"],"prefix":"10.1111","volume":"26","author":[{"given":"Katja","family":"Bieber","sequence":"first","affiliation":[{"name":"L\u00fcbeck Institute of Experimental Dermatology University of L\u00fcbeck L\u00fcbeck Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Anna Lara","family":"Ernst","sequence":"additional","affiliation":[{"name":"L\u00fcbeck Institute of Experimental Dermatology University of 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