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Skin <jats:styled-content style=\"fixed-case\">MC<\/jats:styled-content>s and cutaneous <jats:styled-content style=\"fixed-case\">MC<\/jats:styled-content> responses are subject to the effects of environmental factors including ultraviolet radiation (<jats:styled-content style=\"fixed-case\">UVR<\/jats:styled-content>). Numerous studies have assessed the effects of <jats:styled-content style=\"fixed-case\">UVR<\/jats:styled-content> on <jats:styled-content style=\"fixed-case\">MC<\/jats:styled-content>s, in vitro and in vivo. Interestingly, <jats:styled-content style=\"fixed-case\">UVR<\/jats:styled-content> seems to have variable effects on non\u2010activated and activated mast cells. In general, <jats:styled-content style=\"fixed-case\">UV<\/jats:styled-content> therapy is beneficial in the treatment of urticaria and mastocytosis, but the effects are variable depending on treatment regimen and type of <jats:styled-content style=\"fixed-case\">UVR<\/jats:styled-content>. Here, we review and summarise key reports from the older and current literature on the crosstalk of <jats:styled-content style=\"fixed-case\">UVR<\/jats:styled-content> and skin <jats:styled-content style=\"fixed-case\">MC<\/jats:styled-content>s. Specifically, we present the literature and discuss published reports on the effects of <jats:styled-content style=\"fixed-case\">UVR<\/jats:styled-content> on skin <jats:styled-content style=\"fixed-case\">MC<\/jats:styled-content>s in rodents and humans. In addition, we review the role of <jats:styled-content style=\"fixed-case\">MC<\/jats:styled-content>s in <jats:styled-content style=\"fixed-case\">UVR<\/jats:styled-content>\u2010driven skin diseases and the influence of <jats:styled-content style=\"fixed-case\">UV<\/jats:styled-content> light on <jats:styled-content style=\"fixed-case\">MC<\/jats:styled-content>\u2010mediated skin diseases. This summary of our current understanding of the interplay of skin <jats:styled-content style=\"fixed-case\">MC<\/jats:styled-content>s and <jats:styled-content style=\"fixed-case\">UVR<\/jats:styled-content> may help to improve the management of patients with urticaria and other <jats:styled-content style=\"fixed-case\">MC<\/jats:styled-content> disorders, to identify current gaps of knowledge, and to guide further research.<\/jats:p>","DOI":"10.1111\/exd.13402","type":"journal-article","created":{"date-parts":[[2017,7,5]],"date-time":"2017-07-05T02:52:43Z","timestamp":1499223163000},"page":"3-8","source":"Crossref","is-referenced-by-count":34,"title":["Ultraviolet radiation and skin mast cells: Effects, mechanisms and relevance for skin diseases"],"prefix":"10.1111","volume":"27","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-4604-8136","authenticated-orcid":false,"given":"Hanna","family":"Siiskonen","sequence":"first","affiliation":[{"name":"Department of Dermatology and Allergy Allergie\u2010Centrum\u2010Charit\u00e9 Charit\u00e9 \u2010 Universit\u00e4tsmedizin  Berlin Germany"},{"name":"Department of Dermatology University of Eastern Finland and Kuopio University Hospital  Kuopio Finland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Anna","family":"Smorodchenko","sequence":"additional","affiliation":[{"name":"Department of Dermatology and Allergy Allergie\u2010Centrum\u2010Charit\u00e9 Charit\u00e9 \u2010 Universit\u00e4tsmedizin  Berlin Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Karoline","family":"Krause","sequence":"additional","affiliation":[{"name":"Department of Dermatology and Allergy Allergie\u2010Centrum\u2010Charit\u00e9 Charit\u00e9 \u2010 Universit\u00e4tsmedizin  Berlin Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-4121-481X","authenticated-orcid":false,"given":"Marcus","family":"Maurer","sequence":"additional","affiliation":[{"name":"Department of Dermatology and Allergy Allergie\u2010Centrum\u2010Charit\u00e9 Charit\u00e9 \u2010 Universit\u00e4tsmedizin  Berlin Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2017,9,14]]},"reference":[{"key":"e_1_2_8_2_1","volume-title":"Beitr\u00e4ge zur Theorie und Praxis der histologischen F\u00e4rbung","author":"Ehrlich P.","year":"1878"},{"key":"e_1_2_8_3_1","doi-asserted-by":"publisher","DOI":"10.1369\/0022155414545334"},{"key":"e_1_2_8_4_1","doi-asserted-by":"publisher","DOI":"10.2340\/00015555-1197"},{"key":"e_1_2_8_5_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ajpath.2015.06.024"},{"key":"e_1_2_8_6_1","doi-asserted-by":"crossref","first-page":"259","DOI":"10.4049\/jimmunol.144.1.259","volume":"144","author":"Matsuda H.","year":"1990","journal-title":"J. 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