{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,27]],"date-time":"2026-09-27T08:59:04Z","timestamp":1790499544692,"version":"4.1.0"},"reference-count":9,"publisher":"Wiley","issue":"12","license":[{"start":{"date-parts":[[2017,10,29]],"date-time":"2017-10-29T00:00:00Z","timestamp":1509235200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Experimental Dermatology"],"published-print":{"date-parts":[[2017,12]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>Autoantibodies against the 3 desmocollin (Dsc; Dsc1\u2010Dsc3) isoforms have been described in different pemphigus variants. Here, we developed state\u2010of\u2010the\u2010art detection systems for serum anti\u2010Dsc1, Dsc2 and Dsc1 IgG and IgA. These assays were applied in 5 different cohorts including pemphigus vulgaris (<jats:styled-content style=\"fixed-case\">PV<\/jats:styled-content>) patients with compatible direct immunofluorescence (<jats:styled-content style=\"fixed-case\">IF<\/jats:styled-content>) microscopy but no reactivity against desmogleins 1 and 3 (n\u00a0=\u00a024) and sera from patients with autoimmune blistering diseases with positive direct <jats:styled-content style=\"fixed-case\">IF<\/jats:styled-content> microscopy taken at the time of diagnosis (n\u00a0=\u00a0749). We found that detection of anti\u2010Dsc serum reactivity is not helpful in the routine diagnosis of <jats:styled-content style=\"fixed-case\">PV<\/jats:styled-content>, pemphigus foliaceus and paraneoplastic pemphigus but may be valuable in pemphigus vegetans.<\/jats:p>","DOI":"10.1111\/exd.13409","type":"journal-article","created":{"date-parts":[[2017,8,17]],"date-time":"2017-08-17T07:00:03Z","timestamp":1502953203000},"page":"1267-1270","source":"Crossref","is-referenced-by-count":41,"title":["Routine detection of serum antidesmocollin autoantibodies is only useful in patients with atypical pemphigus"],"prefix":"10.1111","volume":"26","author":[{"given":"Swantje","family":"Mindorf","sequence":"first","affiliation":[{"name":"Institute of Experimental Immunology Euroimmun AG L\u00fcbeck Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Inga M.","family":"Dettmann","sequence":"additional","affiliation":[{"name":"Institute of Experimental Immunology Euroimmun AG L\u00fcbeck Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Stine","family":"Kr\u00fcger","sequence":"additional","affiliation":[{"name":"L\u00fcbeck Institute of Experimental Dermatology (LIED) L\u00fcbeck Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tarek","family":"Fuhrmann","sequence":"additional","affiliation":[{"name":"L\u00fcbeck Institute of Experimental Dermatology (LIED) L\u00fcbeck Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kristin","family":"Rentzsch","sequence":"additional","affiliation":[{"name":"Institute of Experimental Immunology Euroimmun AG L\u00fcbeck Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ingolf","family":"Karl","sequence":"additional","affiliation":[{"name":"L\u00fcbeck Institute of Experimental Dermatology (LIED) L\u00fcbeck Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Christian","family":"Probst","sequence":"additional","affiliation":[{"name":"Institute of Experimental Immunology Euroimmun AG L\u00fcbeck Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lars","family":"Komorowski","sequence":"additional","affiliation":[{"name":"Institute of Experimental Immunology Euroimmun AG L\u00fcbeck Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kai","family":"Fechner","sequence":"additional","affiliation":[{"name":"Institute of Experimental Immunology Euroimmun AG L\u00fcbeck Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nina","family":"van Beek","sequence":"additional","affiliation":[{"name":"Department of Dermatology University of L\u00fcbeck L\u00fcbeck Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-0803-0813","authenticated-orcid":false,"given":"Susanne","family":"Lemcke","sequence":"additional","affiliation":[{"name":"L\u00fcbeck Institute of Experimental Dermatology (LIED) L\u00fcbeck Germany"},{"name":"Human Immunophenotyping Laboratory University of L\u00fcbeck L\u00fcbeck Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mikl\u00f3s","family":"S\u00e1rdy","sequence":"additional","affiliation":[{"name":"Department of Dermatology Ludwig Maximilian University of Munich Munich Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Christine","family":"Bangert","sequence":"additional","affiliation":[{"name":"Department of Dermatology Medical University of Vienna Vienna Austria"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sandrine","family":"Benoit","sequence":"additional","affiliation":[{"name":"Department of Dermatology, Venereology and Allergy University Hospital W\u00fcrzburg W\u00fcrzburg Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-0144-3255","authenticated-orcid":false,"given":"Takashi","family":"Hashimoto","sequence":"additional","affiliation":[{"name":"Department of Dermatology Kurume University School of Medicine and Kurume University Institute of Cutaneous Cell Biology Kurume Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Detlef","family":"Zillikens","sequence":"additional","affiliation":[{"name":"Department of Dermatology University of L\u00fcbeck L\u00fcbeck Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hendri H.","family":"Pas","sequence":"additional","affiliation":[{"name":"Department of Dermatology University Medical Centre Groningen Groningen The Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Marcel F.","family":"Jonkman","sequence":"additional","affiliation":[{"name":"Department of Dermatology University Medical Centre Groningen Groningen The Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Winfried","family":"St\u00f6cker","sequence":"additional","affiliation":[{"name":"Institute of Experimental Immunology Euroimmun AG L\u00fcbeck Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-1206-8913","authenticated-orcid":false,"given":"Enno","family":"Schmidt","sequence":"additional","affiliation":[{"name":"L\u00fcbeck Institute of Experimental Dermatology (LIED) L\u00fcbeck Germany"},{"name":"Department of Dermatology University of L\u00fcbeck L\u00fcbeck Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"name":"the International Autoimmune Bullous Diseases Study 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