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Histologically, the dermal infiltration of eosinophils is obvious. The objective of this review was to present evidence that eosinophils play a key role in the pathogenesis of <jats:styled-content style=\"fixed-case\">BP<\/jats:styled-content>. Eosinophils, together with cytokines and chemokines regulating their production, recruitment and activation, are abundantly present in lesional skin, in blisters and in peripheral blood of patients with <jats:styled-content style=\"fixed-case\">BP<\/jats:styled-content>. Recently, using a cryosection model, eosinophils were demonstrated to induce dermal\u2010epidermal separation in the presence of <jats:styled-content style=\"fixed-case\">BP<\/jats:styled-content> antibodies. Thus, eosinophils and their products, as well as mediators regulating their function, present promising targets for the treatment of <jats:styled-content style=\"fixed-case\">BP<\/jats:styled-content>.<\/jats:p>","DOI":"10.1111\/exd.13416","type":"journal-article","created":{"date-parts":[[2017,8,20]],"date-time":"2017-08-20T10:26:35Z","timestamp":1503224795000},"page":"1187-1192","source":"Crossref","is-referenced-by-count":34,"title":["Eosinophils as putative therapeutic targets in bullous pemphigoid"],"prefix":"10.1111","volume":"26","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-8965-9407","authenticated-orcid":false,"given":"Dagmar","family":"Simon","sequence":"first","affiliation":[{"name":"Department of Dermatology, Inselspital, Bern University Hospital University of Bern Bern Switzerland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Luca","family":"Borradori","sequence":"additional","affiliation":[{"name":"Department of Dermatology, Inselspital, Bern University Hospital University of Bern Bern Switzerland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hans\u2010Uwe","family":"Simon","sequence":"additional","affiliation":[{"name":"Institute of Pharmacology University of Bern Bern Switzerland"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2017,10,26]]},"reference":[{"key":"e_1_2_13_2_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jaad.2014.02.030"},{"key":"e_1_2_13_3_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2133.2012.11108.x"},{"key":"e_1_2_13_4_1","doi-asserted-by":"publisher","DOI":"10.1111\/bjd.13717"},{"key":"e_1_2_13_5_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0065-2776(08)60503-9"},{"key":"e_1_2_13_6_1","doi-asserted-by":"publisher","DOI":"10.1172\/JCI116856"},{"key":"e_1_2_13_7_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1398-9995.2011.02694.x"},{"key":"e_1_2_13_8_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jaci.2007.02.010"},{"key":"e_1_2_13_9_1","doi-asserted-by":"publisher","DOI":"10.1001\/archinte.1939.00190010115010"},{"key":"e_1_2_13_10_1","doi-asserted-by":"publisher","DOI":"10.1182\/blood.V79.12.3101.bloodjournal79123101"},{"key":"e_1_2_13_11_1","doi-asserted-by":"crossref","first-page":"3902","DOI":"10.4049\/jimmunol.158.8.3902","volume":"158","author":"Simon H. 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