{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,1,15]],"date-time":"2026-01-15T21:05:23Z","timestamp":1768511123050,"version":"3.49.0"},"reference-count":13,"publisher":"Wiley","issue":"12","license":[{"start":{"date-parts":[[2017,12,27]],"date-time":"2017-12-27T00:00:00Z","timestamp":1514332800000},"content-version":"vor","delay-in-days":26,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["81371325"],"award-info":[{"award-number":["81371325"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["81571593"],"award-info":[{"award-number":["81571593"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001659","name":"Deutsche Forschungsgemeinschaft","doi-asserted-by":"publisher","award":["GRK1727"],"award-info":[{"award-number":["GRK1727"]}],"id":[{"id":"10.13039\/501100001659","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Experimental Dermatology"],"published-print":{"date-parts":[[2017,12]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p><jats:styled-content style=\"fixed-case\">CD<\/jats:styled-content>11b, the \u03b1\u2010chain of \u03b2<jats:sub>2<\/jats:sub> integrin Mac\u20101, is involved in many activation processes of phagocytes. Depending on the respective autoimmune disorder, <jats:styled-content style=\"fixed-case\">CD<\/jats:styled-content>11b has been shown to exert pro\u2010inflammatory functions or be dispensable in their pathogenesis. Here, we investigated the role of <jats:styled-content style=\"fixed-case\">CD<\/jats:styled-content>11b in the pathogenesis of experimental epidermolysis bullosa acquisita (<jats:styled-content style=\"fixed-case\">EBA<\/jats:styled-content>), an autoimmune skin blistering disease mediated by autoantibodies to type <jats:styled-content style=\"fixed-case\">VII<\/jats:styled-content> collagen. Unexpectedly, in an antibody transfer\u2010induced model of <jats:styled-content style=\"fixed-case\">EBA<\/jats:styled-content>,<jats:styled-content style=\"fixed-case\"> CD<\/jats:styled-content>11b\u2010deficient mice developed more severe disease symptoms than wild\u2010type mice in the late phase of the disease. Furthermore, as compared to wild\u2010type controls, <jats:styled-content style=\"fixed-case\">CD<\/jats:styled-content>11b\u2010deficient mice expressed increased levels of circulating <jats:styled-content style=\"fixed-case\">IFN<\/jats:styled-content>\u2010\u03b3 and <jats:styled-content style=\"fixed-case\">IL<\/jats:styled-content>\u20104. Taken together, for the first time, our results suggest an anti\u2010inflammatory role for <jats:styled-content style=\"fixed-case\">CD<\/jats:styled-content>11b in experimental autoimmune diseases.<\/jats:p>","DOI":"10.1111\/exd.13434","type":"journal-article","created":{"date-parts":[[2017,8,31]],"date-time":"2017-08-31T12:07:16Z","timestamp":1504181236000},"page":"1175-1178","source":"Crossref","is-referenced-by-count":10,"title":["<scp>CD<\/scp>11b\u2010deficient mice exhibit an increased severity in the late phase of antibody transfer\u2010induced experimental epidermolysis bullosa acquisita"],"prefix":"10.1111","volume":"26","author":[{"given":"Fengyuan","family":"Deng","sequence":"first","affiliation":[{"name":"Xiamen\u2010Borstel Joint Laboratory of Autoimmunity Medical College of Xiamen University  Xiamen China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yan","family":"Chen","sequence":"additional","affiliation":[{"name":"Xiamen\u2010Borstel Joint Laboratory of Autoimmunity Medical College of Xiamen University  Xiamen China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Junfeng","family":"Zheng","sequence":"additional","affiliation":[{"name":"Institute of Psychiatry and Neuroscience Xinxiang Medical University  XinXiang Henan China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Qiaoniang","family":"Huang","sequence":"additional","affiliation":[{"name":"Xiamen\u2010Borstel Joint Laboratory of Autoimmunity Medical College of Xiamen University  Xiamen China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Xuetao","family":"Cao","sequence":"additional","affiliation":[{"name":"National Key Laboratory of Medical Molecular Biology Department of Immunology Institute of Basic Medical Sciences Peking Union Medical College Chinese Academy of Medical Sciences  Beijing China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Detlef","family":"Zillikens","sequence":"additional","affiliation":[{"name":"Department of Dermatology University of L\u00fcbeck  L\u00fcbeck Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Frank","family":"Petersen","sequence":"additional","affiliation":[{"name":"Priority Area Asthma &amp; Allergy Research Center Borstel Airway Research Center North (ARCN) German Center for Lung Research (DZL)  Borstel Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-3014-3435","authenticated-orcid":false,"given":"Xinhua","family":"Yu","sequence":"additional","affiliation":[{"name":"Xiamen\u2010Borstel Joint Laboratory of Autoimmunity Medical College of Xiamen University  Xiamen China"},{"name":"Priority Area Asthma &amp; Allergy Research Center Borstel Airway Research Center North (ARCN) German Center for Lung Research (DZL)  Borstel Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2017,12,27]]},"reference":[{"key":"e_1_2_2_2_1","doi-asserted-by":"publisher","DOI":"10.1007\/978-1-61779-166-6_17"},{"key":"e_1_2_2_3_1","doi-asserted-by":"publisher","DOI":"10.1042\/BSR20110101"},{"key":"e_1_2_2_4_1","doi-asserted-by":"publisher","DOI":"10.4049\/jimmunol.175.10.6327"},{"key":"e_1_2_2_5_1","doi-asserted-by":"publisher","DOI":"10.1182\/blood-2005-08-3123"},{"key":"e_1_2_2_6_1","doi-asserted-by":"publisher","DOI":"10.4049\/jimmunol.174.6.3668"},{"key":"e_1_2_2_7_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0002-9440(10)63325-1"},{"key":"e_1_2_2_8_1","doi-asserted-by":"publisher","DOI":"10.3109\/08916934.2011.606450"},{"key":"e_1_2_2_9_1","doi-asserted-by":"publisher","DOI":"10.4049\/jimmunol.177.5.3461"},{"key":"e_1_2_2_10_1","doi-asserted-by":"publisher","DOI":"10.1002\/eji.201444769"},{"key":"e_1_2_2_11_1","doi-asserted-by":"publisher","DOI":"10.1172\/JCI200521386"},{"key":"e_1_2_2_12_1","doi-asserted-by":"publisher","DOI":"10.1038\/ni.1908"},{"key":"e_1_2_2_13_1","doi-asserted-by":"publisher","DOI":"10.1002\/hep.28001"},{"key":"e_1_2_2_14_1","doi-asserted-by":"publisher","DOI":"10.1556\/1886.2015.00038"}],"container-title":["Experimental Dermatology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1111%2Fexd.13434","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/exd.13434","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,9,13]],"date-time":"2023-09-13T12:41:11Z","timestamp":1694608871000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1111\/exd.13434"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2017,12]]},"references-count":13,"journal-issue":{"issue":"12","published-print":{"date-parts":[[2017,12]]}},"alternative-id":["10.1111\/exd.13434"],"URL":"https:\/\/doi.org\/10.1111\/exd.13434","archive":["Portico"],"relation":{},"ISSN":["0906-6705","1600-0625"],"issn-type":[{"value":"0906-6705","type":"print"},{"value":"1600-0625","type":"electronic"}],"subject":[],"published":{"date-parts":[[2017,12]]}}}