{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,29]],"date-time":"2026-04-29T11:10:54Z","timestamp":1777461054405,"version":"3.51.4"},"reference-count":18,"publisher":"Wiley","issue":"12","license":[{"start":{"date-parts":[[2017,12,27]],"date-time":"2017-12-27T00:00:00Z","timestamp":1514332800000},"content-version":"vor","delay-in-days":26,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/501100001659","name":"Deutsche Forschungsgemeinschaft","doi-asserted-by":"publisher","award":["GRK 1727\/2 project TP1"],"award-info":[{"award-number":["GRK 1727\/2 project TP1"]}],"id":[{"id":"10.13039\/501100001659","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001659","name":"Deutsche Forschungsgemeinschaft","doi-asserted-by":"publisher","award":["EXC306\/XTP4"],"award-info":[{"award-number":["EXC306\/XTP4"]}],"id":[{"id":"10.13039\/501100001659","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Experimental Dermatology"],"published-print":{"date-parts":[[2017,12]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>Autoimmune diseases affect a large fraction of the population in Western countries. To elucidate the underlying causes, autoantibody transfer\u2010induced mouse models have been established that greatly contributed to the understanding of the pathophysiology of these diseases. However, the role of a potentially co\u2010occurring murine xenogeneic immune response to commonly utilized rabbit anti\u2010mouse IgG remains poorly understood. Using the established rabbit anti\u2010mouse type <jats:styled-content style=\"fixed-case\">VII<\/jats:styled-content> collagen (<jats:styled-content style=\"fixed-case\">COL<\/jats:styled-content>7) IgG\u2010induced mouse model of the mucocutaneous blistering disorder epidermolysis bullosa acquisita (<jats:styled-content style=\"fixed-case\">EBA<\/jats:styled-content>), we found in this study a profound T\u2010 and B\u2010cell response along with an altered cytokine expression profile in draining lymph nodes of mice injected with the xenogeneic IgG. This was associated with the formation of circulating and skin\u2010bound mouse anti\u2010rabbit IgG in wild\u2010type but not <jats:styled-content style=\"fixed-case\">CD<\/jats:styled-content>154\u2010deficient or B\u2010cell\u2010deficient <jats:styled-content style=\"fixed-case\">JHT<\/jats:styled-content> mice challenged with pathogenic rabbit IgG. Development of <jats:styled-content style=\"fixed-case\">EBA<\/jats:styled-content> skin lesions was attenuated in the two mouse strains lacking a B\u2010cell response at later observation time points, but was not affected in mice treated with the T\u2010cell trafficking blocker <jats:styled-content style=\"fixed-case\">FTY<\/jats:styled-content>720. Collectively, our results implicate a host's xenoreactive immune response to rabbit anti\u2010mouse <jats:styled-content style=\"fixed-case\">COL<\/jats:styled-content>7 IgG, a confounding effect that may contribute to immune complex\u2010driven inflammation and tissue damage in this antibody transfer\u2010induced <jats:styled-content style=\"fixed-case\">EBA<\/jats:styled-content> mouse model, especially at later time points. In this regard, it may be recommended to finish the evaluation of results obtained by experiments employing antibody\u2010transferred mouse models within the first 2\u00a0weeks after the pathogenic antibody injection.<\/jats:p>","DOI":"10.1111\/exd.13439","type":"journal-article","created":{"date-parts":[[2017,9,9]],"date-time":"2017-09-09T02:33:05Z","timestamp":1504924385000},"page":"1207-1213","source":"Crossref","is-referenced-by-count":9,"title":["Evidence for a contributory role of a xenogeneic immune response in experimental epidermolysis bullosa acquisita"],"prefix":"10.1111","volume":"26","author":[{"given":"Markus","family":"Niebuhr","sequence":"first","affiliation":[{"name":"Institute of Anatomy University of L\u00fcbeck  L\u00fcbeck Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Michael","family":"Kasperkiewicz","sequence":"additional","affiliation":[{"name":"Department of Dermatology University of L\u00fcbeck  L\u00fcbeck Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Sebastian","family":"Maass","sequence":"additional","affiliation":[{"name":"Institute of Anatomy University of L\u00fcbeck  L\u00fcbeck Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Eva","family":"Hauenschild","sequence":"additional","affiliation":[{"name":"Institute of Anatomy University of L\u00fcbeck  L\u00fcbeck Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Katja","family":"Bieber","sequence":"additional","affiliation":[{"name":"L\u00fcbeck Institute of Experimental Dermatology University of L\u00fcbeck  L\u00fcbeck Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ralf J.","family":"Ludwig","sequence":"additional","affiliation":[{"name":"Department of Dermatology University of L\u00fcbeck  L\u00fcbeck Germany"},{"name":"L\u00fcbeck Institute of Experimental Dermatology University of L\u00fcbeck  L\u00fcbeck Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"J\u00fcrgen","family":"Westermann","sequence":"additional","affiliation":[{"name":"Institute of Anatomy University of L\u00fcbeck  L\u00fcbeck Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Kathrin","family":"Kalies","sequence":"additional","affiliation":[{"name":"Institute of Anatomy University of L\u00fcbeck  L\u00fcbeck Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2017,12,27]]},"reference":[{"key":"e_1_2_8_2_1","doi-asserted-by":"publisher","DOI":"10.2174\/1381612821666150316122502"},{"key":"e_1_2_8_3_1","doi-asserted-by":"publisher","DOI":"10.1038\/JID.2015.356"},{"key":"e_1_2_8_4_1","doi-asserted-by":"publisher","DOI":"10.1038\/ki.1997.97"},{"key":"e_1_2_8_5_1","doi-asserted-by":"publisher","DOI":"10.4049\/jimmunol.172.8.5047"},{"key":"e_1_2_8_6_1","doi-asserted-by":"publisher","DOI":"10.1002\/art.10887"},{"key":"e_1_2_8_7_1","doi-asserted-by":"publisher","DOI":"10.1038\/srep38357"},{"key":"e_1_2_8_8_1","doi-asserted-by":"publisher","DOI":"10.1172\/JCI200521386"},{"key":"e_1_2_8_9_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00430-011-0201-6"},{"key":"e_1_2_8_10_1","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0067746"},{"key":"e_1_2_8_11_1","doi-asserted-by":"publisher","DOI":"10.4049\/jimmunol.1100796"},{"key":"e_1_2_8_12_1","doi-asserted-by":"publisher","DOI":"10.4049\/jimmunol.0901412"},{"key":"e_1_2_8_13_1","doi-asserted-by":"publisher","DOI":"10.1111\/jdv.12091"},{"key":"e_1_2_8_14_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1600-0625.2011.01378.x"},{"key":"e_1_2_8_15_1","author":"Yuan H.","year":"2017","journal-title":"J. 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