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Tissue inhibitor of metalloproteinases\u20101 (TIMP\u20101) was known to have effects on promoting growth and anti\u2010apoptosis for cells. We aimed to determine the actual levels of TIMP\u20101 and cell apoptosis in: (i) the biopsies of diabetic and non\u2010diabetic foot tissue and (ii) the human fibroblasts with or without treatments of advanced glycation end\u2010products (AGEs). Next, we aimed to determine the improved levels of cell apoptosis and wound healing after the treatments of either active protein of TIMP\u20101 or in vivo expression of gene therapy vector\u2010mediated TIMP\u20101 in both the human fibroblasts and the animal model of diabetic rats. The levels of TIMP\u20101 were significantly reduced in diabetic skin tissues and in AGEs\u2010treated fibroblasts. Both AGEs\u2010treated cells were effectively protected from apoptosis by active protein of TIMP\u20101 at appropriate dose level. So did the induced in vivo TIMP\u20101 expression after gene delivery. Similar effects were also found on the significant improvement of impaired wound healing in diabetic rats. We concluded that TIMP\u20101 improved wound healing through its anti\u2010apoptotic effect. Treatments with either active protein TIMP\u20101 or TIMP\u20101 gene therapy delivered in local wound sites may be used as a strategy for accelerating diabetic wound healing.<\/jats:p>","DOI":"10.1111\/exd.13442","type":"journal-article","created":{"date-parts":[[2017,9,9]],"date-time":"2017-09-09T02:33:09Z","timestamp":1504924389000},"page":"528-535","source":"Crossref","is-referenced-by-count":37,"title":["Human tissue inhibitor of metalloproteinases\u20101 improved wound healing in diabetes through its anti\u2010apoptotic effect"],"prefix":"10.1111","volume":"28","author":[{"given":"Guojuan","family":"Lao","sequence":"first","affiliation":[{"name":"Department of Endocrinology Sun Yat\u2010sen Memorial Hospital Sun Yat\u2010sen University  Guangzhou China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Meng","family":"Ren","sequence":"additional","affiliation":[{"name":"Department of Endocrinology Sun Yat\u2010sen Memorial Hospital Sun Yat\u2010sen University  Guangzhou China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xiaoyi","family":"Wang","sequence":"additional","affiliation":[{"name":"Department of Endocrinology Sun Yat\u2010sen Memorial Hospital Sun Yat\u2010sen University  Guangzhou China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jinglu","family":"Zhang","sequence":"additional","affiliation":[{"name":"Department of Endocrinology Sun Yat\u2010sen Memorial Hospital Sun Yat\u2010sen University  Guangzhou China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yanrui","family":"Huang","sequence":"additional","affiliation":[{"name":"Department of Endocrinology Sun Yat\u2010sen Memorial Hospital Sun Yat\u2010sen University  Guangzhou China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Dan","family":"Liu","sequence":"additional","affiliation":[{"name":"Department of Endocrinology Sun Yat\u2010sen Memorial Hospital Sun Yat\u2010sen University  Guangzhou China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hengcong","family":"Luo","sequence":"additional","affiliation":[{"name":"Department of Endocrinology Sun Yat\u2010sen Memorial Hospital Sun Yat\u2010sen University  Guangzhou China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Chuan","family":"Yang","sequence":"additional","affiliation":[{"name":"Department of Endocrinology Sun Yat\u2010sen Memorial Hospital Sun Yat\u2010sen University  Guangzhou China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-0303-0921","authenticated-orcid":false,"given":"Li","family":"Yan","sequence":"additional","affiliation":[{"name":"Department of Endocrinology Sun Yat\u2010sen Memorial Hospital Sun Yat\u2010sen University  Guangzhou China"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2018,1,5]]},"reference":[{"key":"e_1_2_8_2_1","doi-asserted-by":"publisher","DOI":"10.1038\/nrendo.2011.183"},{"key":"e_1_2_8_3_1","doi-asserted-by":"publisher","DOI":"10.1007\/s11892-013-0433-5"},{"key":"e_1_2_8_4_1","doi-asserted-by":"publisher","DOI":"10.1007\/PL00002941"},{"key":"e_1_2_8_5_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(03)13169-8"},{"key":"e_1_2_8_6_1","doi-asserted-by":"publisher","DOI":"10.1080\/00015458.2005.11679687"},{"key":"e_1_2_8_7_1","doi-asserted-by":"publisher","DOI":"10.1002\/dmrr.833"},{"key":"e_1_2_8_8_1","doi-asserted-by":"publisher","DOI":"10.4239\/wjd.v5.i6.756"},{"key":"e_1_2_8_9_1","doi-asserted-by":"publisher","DOI":"10.1177\/154405910608500103"},{"key":"e_1_2_8_10_1","first-page":"754","volume":"2013","author":"Xu F.","year":"2013","journal-title":"Biomed. 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