{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,1]],"date-time":"2026-05-01T02:52:19Z","timestamp":1777603939532,"version":"3.51.4"},"reference-count":16,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2017,11,10]],"date-time":"2017-11-10T00:00:00Z","timestamp":1510272000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/501100003725","name":"National Research Foundation of Korea","doi-asserted-by":"publisher","award":["NRF\u20102016R1D1A1B03932749"],"award-info":[{"award-number":["NRF\u20102016R1D1A1B03932749"]}],"id":[{"id":"10.13039\/501100003725","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100003725","name":"National Research Foundation of Korea","doi-asserted-by":"publisher","award":["NRF\u20102012R1A5A2048183"],"award-info":[{"award-number":["NRF\u20102012R1A5A2048183"]}],"id":[{"id":"10.13039\/501100003725","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100003710","name":"Korea Health Industry Development Institute","doi-asserted-by":"publisher","award":["HN14C0094"],"award-info":[{"award-number":["HN14C0094"]}],"id":[{"id":"10.13039\/501100003710","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Experimental Dermatology"],"published-print":{"date-parts":[[2018,1]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>Cutaneous vasculature systems play a role in regulating skin pigmentation. We analysed <jats:styled-content style=\"fixed-case\">RNA<\/jats:styled-content> sequencing data to identify novel antimelanogenic factors secreted from endothelial cells and found that one of the secreted factors, clusterin, is highly expressed by <jats:styled-content style=\"fixed-case\">HDMEC<\/jats:styled-content>s. To investigate the paracrine effect of clusterin from <jats:styled-content style=\"fixed-case\">HDMEC<\/jats:styled-content>s on the regulation of melanogenesis, <jats:styled-content style=\"fixed-case\">HDMEC<\/jats:styled-content>s were infected with clusterin or sh\u2010clusterin lentivirus and the <jats:styled-content style=\"fixed-case\">HDMEC<\/jats:styled-content>\u2010derived conditioned media were used to treat normal human melanocytes. It was found that <jats:styled-content style=\"fixed-case\">HDMEC<\/jats:styled-content>\u2010derived clusterin inhibits melanogenesis through <jats:styled-content style=\"fixed-case\">MITF<\/jats:styled-content>\/tyrosinase downregulation. The findings here suggest that <jats:styled-content style=\"fixed-case\">HDMEC<\/jats:styled-content>s secrete copious amounts of clusterin and that the clusterin is a factor contributing to the inhibitory effect of endothelial cells on melanogenesis <jats:italic>via<\/jats:italic> paracrine crosstalk between endothelial cells and melanocytes.<\/jats:p>","DOI":"10.1111\/exd.13443","type":"journal-article","created":{"date-parts":[[2017,9,9]],"date-time":"2017-09-09T02:33:09Z","timestamp":1504924389000},"page":"98-100","source":"Crossref","is-referenced-by-count":15,"title":["Paracrine crosstalk between endothelial cells and melanocytes through clusterin to inhibit pigmentation"],"prefix":"10.1111","volume":"27","author":[{"given":"Misun","family":"Kim","sequence":"first","affiliation":[{"name":"Department of Dermatology Ajou University School of Medicine  Suwon Korea"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jiun","family":"Lee","sequence":"additional","affiliation":[{"name":"Department of Dermatology Ajou University School of Medicine  Suwon Korea"},{"name":"Department of Biomedical Science The Graduate School Ajou University  Suwon Korea"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Tae Jun","family":"Park","sequence":"additional","affiliation":[{"name":"Department of Biochemistry and Molecular Biology Ajou University School of Medicine  Suwon Korea"},{"name":"Chronic Inflammatory Disease Research Center Ajou University School of Medicine  Suwon Korea"},{"name":"Department of Biomedical Science The Graduate School Ajou University  Suwon Korea"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-8697-4292","authenticated-orcid":false,"given":"Hee Young","family":"Kang","sequence":"additional","affiliation":[{"name":"Department of Dermatology Ajou University School of Medicine  Suwon Korea"},{"name":"Department of Biomedical Science The Graduate School Ajou University  Suwon Korea"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2017,11,10]]},"reference":[{"key":"e_1_2_2_2_1","doi-asserted-by":"publisher","DOI":"10.1111\/exd.12937"},{"key":"e_1_2_2_3_1","doi-asserted-by":"publisher","DOI":"10.1111\/exd.13090"},{"key":"e_1_2_2_4_1","doi-asserted-by":"publisher","DOI":"10.1002\/biof.29"},{"key":"e_1_2_2_5_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jdermsci.2007.01.009"},{"key":"e_1_2_2_6_1","doi-asserted-by":"publisher","DOI":"10.1111\/1346-8138.13458"},{"key":"e_1_2_2_7_1","doi-asserted-by":"publisher","DOI":"10.1172\/JCI69404"},{"key":"e_1_2_2_8_1","doi-asserted-by":"publisher","DOI":"10.1038\/jid.2015.332"},{"key":"e_1_2_2_9_1","doi-asserted-by":"publisher","DOI":"10.1111\/pcmr.12491"},{"key":"e_1_2_2_10_1","doi-asserted-by":"publisher","DOI":"10.1038\/sj.cdd.4401779"},{"key":"e_1_2_2_11_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.anai.2013.12.012"},{"key":"e_1_2_2_12_1","first-page":"2707","volume":"26","author":"Shannan B.","year":"2006","journal-title":"Anticancer Res."},{"key":"e_1_2_2_13_1","doi-asserted-by":"publisher","DOI":"10.1242\/jcs.01651"},{"key":"e_1_2_2_14_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jid.2017.03.035"},{"key":"e_1_2_2_15_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.bbrc.2007.12.033"},{"key":"e_1_2_2_16_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.molcel.2008.11.002"},{"key":"e_1_2_2_17_1","doi-asserted-by":"publisher","DOI":"10.1038\/nature05660"}],"container-title":["Experimental Dermatology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1111%2Fexd.13443","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/exd.13443","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,9,24]],"date-time":"2023-09-24T06:50:25Z","timestamp":1695538225000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1111\/exd.13443"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2017,11,10]]},"references-count":16,"journal-issue":{"issue":"1","published-print":{"date-parts":[[2018,1]]}},"alternative-id":["10.1111\/exd.13443"],"URL":"https:\/\/doi.org\/10.1111\/exd.13443","archive":["Portico"],"relation":{},"ISSN":["0906-6705","1600-0625"],"issn-type":[{"value":"0906-6705","type":"print"},{"value":"1600-0625","type":"electronic"}],"subject":[],"published":{"date-parts":[[2017,11,10]]}}}