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This structural network consists of hemidesmosomal\u2010anchoring filament complexes connecting the basal keratinocytes to the basement membrane. The anchoring filaments in turn interact with the anchoring fibrils to attach the basement membrane to the underlying dermis. Several of these structural proteins are recognized by autoantibodies in pemphigoid diseases, a heterogeneous group of clinically and immunopathologically diverse entities. Targeted proteins include the two intracellular plakins, plectin isoform 1a and\n                    <jats:styled-content style=\"fixed-case\">BP<\/jats:styled-content>\n                    230 (also called bullous pemphigoid antigen (\n                    <jats:styled-content style=\"fixed-case\">BPAG<\/jats:styled-content>\n                    ) 1 isoform e (\n                    <jats:styled-content style=\"fixed-case\">BPAG<\/jats:styled-content>\n                    1e)). Plectin 1a and BP230 are connected to the intermediate filaments and to the cell surface receptor \u03b16\u03b24 integrin, which in turn is connected to laminin 332, a component of the anchoring filaments. Further essential adhesion proteins are\n                    <jats:styled-content style=\"fixed-case\">BP<\/jats:styled-content>\n                    180, a transmembrane protein, laminin \u03b31 and type\n                    <jats:styled-content style=\"fixed-case\">VII<\/jats:styled-content>\n                    collagen. Latter protein is the major constituent of the anchoring fibrils. Mutations in the corresponding genes of these adhesion molecules lead to inherited epidermolysis bullosa emphasizing the importance of these proteins for the integrity of the dermal\u2010epidermal junction. This review will provide an overview on the structure and function of the proteins situated in the dermal\u2010epidermal junction targeted by autoantibodies.\n                  <\/jats:p>","DOI":"10.1111\/exd.13446","type":"journal-article","created":{"date-parts":[[2017,9,8]],"date-time":"2017-09-08T22:33:03Z","timestamp":1504909983000},"page":"1154-1162","source":"Crossref","is-referenced-by-count":91,"title":["Structural proteins of the dermal\u2010epidermal junction targeted by autoantibodies in pemphigoid diseases"],"prefix":"10.1111","volume":"26","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-0355-4290","authenticated-orcid":false,"given":"Stephanie","family":"Goletz","sequence":"first","affiliation":[{"name":"L\u00fcbeck Institute of Experimental Dermatology (LIED) University of L\u00fcbeck  L\u00fcbeck Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Detlef","family":"Zillikens","sequence":"additional","affiliation":[{"name":"Department of Dermatology University of L\u00fcbeck  L\u00fcbeck Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Enno","family":"Schmidt","sequence":"additional","affiliation":[{"name":"L\u00fcbeck Institute of Experimental Dermatology (LIED) University of L\u00fcbeck  L\u00fcbeck Germany"},{"name":"Department of Dermatology University of L\u00fcbeck  L\u00fcbeck Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2017,12,27]]},"reference":[{"key":"e_1_2_14_2_1","doi-asserted-by":"publisher","DOI":"10.1111\/1523-1747.ep12598050"},{"key":"e_1_2_14_3_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.det.2009.10.001"},{"key":"e_1_2_14_4_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0955-0674(05)80005-5"},{"key":"e_1_2_14_5_1","doi-asserted-by":"publisher","DOI":"10.1006\/excr.1994.1166"},{"key":"e_1_2_14_6_1","doi-asserted-by":"publisher","DOI":"10.1002\/(SICI)1521-1878(199806)20:6<488::AID-BIES7>3.0.CO;2-I"},{"key":"e_1_2_14_7_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00441-015-2216-6"},{"key":"e_1_2_14_8_1","doi-asserted-by":"publisher","DOI":"10.1111\/1523-1747.ep12319337"},{"key":"e_1_2_14_9_1","doi-asserted-by":"publisher","DOI":"10.1177\/44.11.8918896"},{"key":"e_1_2_14_10_1","doi-asserted-by":"publisher","DOI":"10.1083\/jcb.103.4.1577"},{"key":"e_1_2_14_11_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jaad.2008.02.004"},{"key":"e_1_2_14_12_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jaad.2014.01.903"},{"key":"e_1_2_14_13_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(12)61140-4"},{"key":"e_1_2_14_14_1","volume-title":"Rook's Textbook of Dermatology","author":"Schmidt E.","year":"2016"},{"key":"e_1_2_14_15_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMra061111"},{"key":"e_1_2_14_16_1","doi-asserted-by":"publisher","DOI":"10.1146\/annurev-pathol-012615-044313"},{"key":"e_1_2_14_17_1","doi-asserted-by":"crossref","first-page":"873","DOI":"10.1001\/archderm.1994.01690070067010","volume":"130","author":"Gao S. 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