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Based on these observations, we asked whether <jats:styled-content style=\"fixed-case\">CDNP<\/jats:styled-content>s would improve inflammatory skin disorders. To address this, we utilized two distinct mouse models of cutaneous inflammation: the autoimmune skin\u2010blistering disease epidermolysis bullosa acquisita (<jats:styled-content style=\"fixed-case\">EBA<\/jats:styled-content>) as an example of an autoantibody\u2010induced cutaneous inflammation, and <jats:italic>Leishmania major<\/jats:italic> (<jats:italic>L.\u00a0major<\/jats:italic>) infection as an example of a pathogen\u2010induced cutaneous inflammation. In both models, we observed that <jats:styled-content style=\"fixed-case\">CDNP<\/jats:styled-content>s increased <jats:styled-content style=\"fixed-case\">mRNA<\/jats:styled-content> expression of the Th2 cytokine <jats:styled-content style=\"fixed-case\">IL<\/jats:styled-content>\u20104. Clinically, <jats:styled-content style=\"fixed-case\">CDNP<\/jats:styled-content>s decreased inflammation due to <jats:styled-content style=\"fixed-case\">EBA<\/jats:styled-content> and increased <jats:italic>L.\u00a0major<\/jats:italic>\u2010specific IgG1 levels without major effects on infected skin lesions. In addition, <jats:styled-content style=\"fixed-case\">CDNP<\/jats:styled-content>s supported the growth of keratinocytes in human skin cultures. In vitro studies revealed that <jats:styled-content style=\"fixed-case\">CDNP<\/jats:styled-content>s were taken up predominantly by macrophages, leading to a shift towards the expression of anti\u2010inflammatory cytokine genes. Altogether, our data demonstrate that treatment with porcine <jats:styled-content style=\"fixed-case\">CDNP<\/jats:styled-content>s may be a new therapeutic option for the control of autoimmune\u2010mediated inflammatory skin disorders.<\/jats:p>","DOI":"10.1111\/exd.13450","type":"journal-article","created":{"date-parts":[[2017,9,23]],"date-time":"2017-09-23T08:03:09Z","timestamp":1506153789000},"page":"1199-1206","source":"Crossref","is-referenced-by-count":6,"title":["Nanoparticles prepared from porcine cells support the healing of cutaneous inflammation in mice and wound re\u2010epithelialization in human skin"],"prefix":"10.1111","volume":"26","author":[{"given":"Natalia","family":"Kunz","sequence":"first","affiliation":[{"name":"Institute of Anatomy University of Luebeck Luebeck Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Eva","family":"Hauenschild","sequence":"additional","affiliation":[{"name":"Institute of Anatomy University of Luebeck Luebeck Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Sebastian","family":"Maass","sequence":"additional","affiliation":[{"name":"Institute of Anatomy University of Luebeck Luebeck Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Kai\u2010Uwe","family":"Kalies","sequence":"additional","affiliation":[{"name":"Institute of Biology University of Luebeck Luebeck Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Matthias","family":"Klinger","sequence":"additional","affiliation":[{"name":"Institute of Anatomy University of Luebeck Luebeck Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Melanie","family":"Barra","sequence":"additional","affiliation":[{"name":"Institute of Anatomy University of Luebeck Luebeck Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Lars","family":"Hecht","sequence":"additional","affiliation":[{"name":"Varicula Biotec GmbH Teterow Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Franz","family":"Helbig","sequence":"additional","affiliation":[{"name":"Varicula Biotec GmbH Teterow Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Stefan","family":"Soellner","sequence":"additional","affiliation":[{"name":"Clinic for Aesthetic\u2010Plastic Surgery Prien Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Charles C.","family":"Caldwell","sequence":"additional","affiliation":[{"name":"Division of Research Department of Surgery University of Cincinnati College of Medicine Cincinnati OH USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-1394-1737","authenticated-orcid":false,"given":"Ralf J.","family":"Ludwig","sequence":"additional","affiliation":[{"name":"The L\u00fcbeck Institute of Experimental Dermatology University of Luebeck Luebeck Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"J\u00fcrgen","family":"Westermann","sequence":"additional","affiliation":[{"name":"Institute of Anatomy University of Luebeck Luebeck Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-8929-4249","authenticated-orcid":false,"given":"Kathrin","family":"Kalies","sequence":"additional","affiliation":[{"name":"Institute of Anatomy University of Luebeck Luebeck Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2017,11,7]]},"reference":[{"key":"e_1_2_8_2_1","doi-asserted-by":"publisher","DOI":"10.1002\/elsc.200420070"},{"key":"e_1_2_8_3_1","unstructured":"P.Solisch K.\u2010U.Kalies S.Bergmann Patent. 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