{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,10]],"date-time":"2026-06-10T02:46:39Z","timestamp":1781059599169,"version":"3.54.1"},"reference-count":9,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2017,12,6]],"date-time":"2017-12-06T00:00:00Z","timestamp":1512518400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/501100001659","name":"Deutsche Forschungsgemeinschaft","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100001659","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Experimental Dermatology"],"published-print":{"date-parts":[[2018,1]]},"abstract":"Abstract<\/jats:title>Healing of leishmaniasis\u2014a parasitic skin disease\u2014is associated with high levels of secreted interferon (IFN<\/jats:styled-content>)\u03b3 and IL<\/jats:styled-content>\u201012 in resistant C57BL<\/jats:styled-content>\/6 mice and humans. Susceptible BALB<\/jats:styled-content>\/c mice predominantly react with a Th17\/Th2\/Treg\u2010related immune response and finally succumb to infection. Previously, we showed that BALB<\/jats:styled-content>\/c IL<\/jats:styled-content>\u201017A\u2212\/\u2212<\/jats:sup> mice are protected against Leishmania (L.) major<\/jats:italic> infections, indicating that IL<\/jats:styled-content>\u201017A\u2014predominantly produced by Th17 cells\u2014plays an important role for disease outcome. We now investigated DC<\/jats:styled-content>\u2010derived cytokines and finally identified IL<\/jats:styled-content>\u201023p19 as key cytokine responsible for induction of Leishmania<\/jats:italic>\u2010specific Th17 cells that play an important role for progressive disease in susceptible BALB<\/jats:styled-content>\/c mice.<\/jats:p>","DOI":"10.1111\/exd.13455","type":"journal-article","created":{"date-parts":[[2017,10,27]],"date-time":"2017-10-27T19:46:36Z","timestamp":1509133596000},"page":"101-103","source":"Crossref","is-referenced-by-count":10,"title":["Insufficient generation of Th17 cells in IL<\/scp>\u201023p19\u2010deficient BALB<\/scp>\/c mice protects against progressive cutaneous leishmaniasis"],"prefix":"10.1111","volume":"27","author":[{"given":"Kirsten","family":"Dietze\u2010Schwonberg","sequence":"first","affiliation":[{"name":"Department of Dermatology University Hospital of the Johannes Gutenberg\u2010University Mainz Mainz Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Beate","family":"Lorenz","sequence":"additional","affiliation":[{"name":"Department of Dermatology University Hospital of the Johannes Gutenberg\u2010University Mainz Mainz Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Susanna Lopez","family":"Kostka","sequence":"additional","affiliation":[{"name":"Department of Dermatology University Hospital of the Johannes Gutenberg\u2010University Mainz Mainz Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Beatrix","family":"Schumak","sequence":"additional","affiliation":[{"name":"Institute of Medical Microbiology, Immunology and Parasitology University Hospital Bonn Bonn Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Andr\u00e9","family":"Gessner","sequence":"additional","affiliation":[{"name":"Institute of Clinical Microbiology and Hygiene University Medical Center Regensburg Regensburg Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-9802-9642","authenticated-orcid":false,"given":"Esther","family":"von Stebut","sequence":"additional","affiliation":[{"name":"Department of Dermatology University Hospital of the Johannes Gutenberg\u2010University Mainz Mainz Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2017,12,6]]},"reference":[{"key":"e_1_2_9_2_1","doi-asserted-by":"publisher","DOI":"10.1038\/nri933"},{"key":"e_1_2_9_3_1","doi-asserted-by":"publisher","DOI":"10.1038\/ni725"},{"key":"e_1_2_9_4_1","doi-asserted-by":"publisher","DOI":"10.4049\/jimmunol.0713598"},{"key":"e_1_2_9_5_1","doi-asserted-by":"publisher","DOI":"10.1038\/emi.2013.58"},{"key":"e_1_2_9_6_1","doi-asserted-by":"publisher","DOI":"10.2174\/187152812800392805"},{"key":"e_1_2_9_7_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jid.2016.05.111"},{"key":"e_1_2_9_8_1","doi-asserted-by":"publisher","DOI":"10.1126\/science.1159194"},{"key":"e_1_2_9_9_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00335-002-3058-6"},{"key":"e_1_2_9_10_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0167-5699(97)01126-2"}],"container-title":["Experimental Dermatology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1111%2Fexd.13455","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/exd.13455","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,9,24]],"date-time":"2023-09-24T06:50:17Z","timestamp":1695538217000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1111\/exd.13455"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2017,12,6]]},"references-count":9,"journal-issue":{"issue":"1","published-print":{"date-parts":[[2018,1]]}},"alternative-id":["10.1111\/exd.13455"],"URL":"https:\/\/doi.org\/10.1111\/exd.13455","archive":["Portico"],"relation":{},"ISSN":["0906-6705","1600-0625"],"issn-type":[{"value":"0906-6705","type":"print"},{"value":"1600-0625","type":"electronic"}],"subject":[],"published":{"date-parts":[[2017,12,6]]}}}