{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,13]],"date-time":"2026-10-13T14:09:50Z","timestamp":1791900590644,"version":"4.3.4"},"reference-count":130,"publisher":"Wiley","issue":"12","license":[{"start":{"date-parts":[[2017,12,27]],"date-time":"2017-12-27T00:00:00Z","timestamp":1514332800000},"content-version":"vor","delay-in-days":26,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Experimental Dermatology"],"published-print":{"date-parts":[[2017,12]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:p>\n                    Bullous pemphigoid (\n                    <jats:styled-content style=\"fixed-case\">BP<\/jats:styled-content>\n                    ) is the most common autoimmune subepidermal blistering disease of the skin. Investigation of the\n                    <jats:styled-content style=\"fixed-case\">BP<\/jats:styled-content>\n                    \u2010associated pathophysiological processes during the last decades showed that the generation of autoantibodies directed against the hemidesmosome proteins\n                    <jats:styled-content style=\"fixed-case\">BP<\/jats:styled-content>\n                    180 and\n                    <jats:styled-content style=\"fixed-case\">BP<\/jats:styled-content>\n                    230, a hallmark of the\n                    <jats:styled-content style=\"fixed-case\">BP<\/jats:styled-content>\n                    \u2010associated autoimmune response, leads to the recruitment of inflammatory immune cells at the dermal\u2010epidermal junction, and subsequently to the release of a large amount of inflammatory molecules involved in blister formation. Analysis in transversal and longitudinal studies of autoantibodies and inflammatory molecules production both at the time of diagnosis and under treatment was mainly performed within the serum but also in the blister fluid. Some autoimmune or inflammatory molecules expression was related to the presence of clinical signs, while others were mere bystanders. In this review, we focused on the autoimmune and inflammatory molecules that have been identified as potential biomarkers of\n                    <jats:styled-content style=\"fixed-case\">BP<\/jats:styled-content>\n                    development and outcome.\n                  <\/jats:p>","DOI":"10.1111\/exd.13459","type":"journal-article","created":{"date-parts":[[2017,11,3]],"date-time":"2017-11-03T13:36:13Z","timestamp":1509716173000},"page":"1240-1247","source":"Crossref","is-referenced-by-count":27,"title":["Biomarkers related to bullous pemphigoid activity and outcome"],"prefix":"10.1111","volume":"26","author":[{"given":"Delphine","family":"Giusti","sequence":"first","affiliation":[{"name":"Laboratory of Dermatology, Faculty of Medicine of Reims IFR CAP Sant\u00e9, University of Reims Champagne\u2010Ardenne  Reims France"},{"name":"Laboratory of Immunology, Reims University Hospital University of Reims Champagne\u2010Ardenne  Reims France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-4027-2855","authenticated-orcid":false,"given":"S\u00e9bastien","family":"Le Jan","sequence":"additional","affiliation":[{"name":"Laboratory of Dermatology, Faculty of Medicine of Reims IFR CAP Sant\u00e9, University of Reims Champagne\u2010Ardenne  Reims France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Gregory","family":"Gatouillat","sequence":"additional","affiliation":[{"name":"Laboratory of Dermatology, Faculty of Medicine of Reims IFR CAP Sant\u00e9, University of Reims Champagne\u2010Ardenne  Reims France"},{"name":"Laboratory of Immunology, Reims University Hospital University of Reims Champagne\u2010Ardenne  Reims France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Philippe","family":"Bernard","sequence":"additional","affiliation":[{"name":"Laboratory of Dermatology, Faculty of Medicine of Reims IFR CAP Sant\u00e9, University of Reims Champagne\u2010Ardenne  Reims France"},{"name":"Department of Dermatology, Reims University Hospital University of Reims Champagne\u2010Ardenne  Reims France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Bach Nga","family":"Pham","sequence":"additional","affiliation":[{"name":"Laboratory of Dermatology, Faculty of Medicine of Reims IFR CAP Sant\u00e9, University of Reims Champagne\u2010Ardenne  Reims France"},{"name":"Laboratory of Immunology, Reims University Hospital University of Reims Champagne\u2010Ardenne  Reims France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Frank","family":"Antonicelli","sequence":"additional","affiliation":[{"name":"Laboratory of Dermatology, Faculty of Medicine of Reims IFR CAP Sant\u00e9, University of Reims Champagne\u2010Ardenne  Reims France"},{"name":"Department of Biological Sciences, Immunology, UFR Odontology University of Reims Champagne\u2010Ardenne  Reims France"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2017,12,27]]},"reference":[{"key":"e_1_2_8_2_1","doi-asserted-by":"publisher","DOI":"10.1136\/bmj.a180"},{"key":"e_1_2_8_3_1","doi-asserted-by":"publisher","DOI":"10.3389\/fimmu.2017.00603"},{"key":"e_1_2_8_4_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2133.1980.tb01683.x"},{"key":"e_1_2_8_5_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2133.1961.tb14442.x"},{"key":"e_1_2_8_6_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0190-9622(87)80227-X"},{"key":"e_1_2_8_7_1","doi-asserted-by":"publisher","DOI":"10.1097\/00062752-200101000-00006"},{"key":"e_1_2_8_8_1","first-page":"123","volume":"10","author":"D'Auria L.","year":"1999","journal-title":"Eur. Cytokine Netw."},{"key":"e_1_2_8_9_1","doi-asserted-by":"publisher","DOI":"10.1016\/0190-9622(93)70170-X"},{"key":"e_1_2_8_10_1","doi-asserted-by":"publisher","DOI":"10.1038\/jid.2014.263"},{"key":"e_1_2_8_11_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jaci.2016.08.012"},{"key":"e_1_2_8_12_1","first-page":"321","volume":"346","author":"Joly P.","year":"2002","journal-title":"J. Med."},{"key":"e_1_2_8_13_1","first-page":"25","volume":"150","author":"Murrell D. F.","year":"2014","journal-title":"J. Am. Acad. Dermatol."},{"key":"e_1_2_8_14_1","doi-asserted-by":"publisher","DOI":"10.1172\/JCI113803"},{"key":"e_1_2_8_15_1","doi-asserted-by":"publisher","DOI":"10.1111\/1523-1747.ep12616580"},{"key":"e_1_2_8_16_1","doi-asserted-by":"publisher","DOI":"10.1111\/1523-1747.ep12337492"},{"key":"e_1_2_8_17_1","first-page":"2015","volume":"176","author":"Thoma\u2010Uszynski S.","year":"2006","journal-title":"J. Immunol. Baltim. Md 1950"},{"key":"e_1_2_8_18_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.clim.2008.04.012"},{"key":"e_1_2_8_19_1","doi-asserted-by":"publisher","DOI":"10.1046\/j.1523-1747.2003.12146.x"},{"key":"e_1_2_8_20_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jid.2016.06.622"},{"key":"e_1_2_8_21_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0923-1811(02)00109-3"},{"key":"e_1_2_8_22_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2133.2004.06082.x"},{"key":"e_1_2_8_23_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jdermsci.2004.10.007"},{"key":"e_1_2_8_24_1","doi-asserted-by":"publisher","DOI":"10.1001\/archdermatol.2011.23"},{"key":"e_1_2_8_25_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-4632.2008.03824.x"},{"key":"e_1_2_8_26_1","doi-asserted-by":"publisher","DOI":"10.1001\/archderm.136.2.174"},{"key":"e_1_2_8_27_1","doi-asserted-by":"publisher","DOI":"10.1001\/archderm.134.9.1075"},{"key":"e_1_2_8_28_1","doi-asserted-by":"publisher","DOI":"10.1111\/1523-1747.ep12507222"},{"key":"e_1_2_8_29_1","first-page":"3461","volume":"177","author":"Sitaru C.","year":"2006","journal-title":"J. Immunol. Baltim. Md 1950"},{"key":"e_1_2_8_30_1","doi-asserted-by":"publisher","DOI":"10.1172\/JCI116856"},{"key":"e_1_2_8_31_1","doi-asserted-by":"publisher","DOI":"10.1038\/nm1496"},{"key":"e_1_2_8_32_1","first-page":"2166","volume":"184","author":"Ujiie H.","year":"2010","journal-title":"J. Immunol. Baltim. Md 1950"},{"key":"e_1_2_8_33_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1600-0625.2007.00592.x"},{"key":"e_1_2_8_34_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ajpath.2014.05.007"},{"key":"e_1_2_8_35_1","doi-asserted-by":"publisher","DOI":"10.1046\/j.1523-1747.2002.19529.x"},{"key":"e_1_2_8_36_1","doi-asserted-by":"publisher","DOI":"10.1001\/archderm.136.2.174"},{"key":"e_1_2_8_37_1","doi-asserted-by":"publisher","DOI":"10.1001\/jamadermatol.2013.5757"},{"key":"e_1_2_8_38_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jaad.2014.06.014"},{"key":"e_1_2_8_39_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00403-015-1606-7"},{"key":"e_1_2_8_40_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1744-9987.2012.01075.x"},{"key":"e_1_2_8_41_1","doi-asserted-by":"publisher","DOI":"10.1159\/000452828"},{"key":"e_1_2_8_42_1","doi-asserted-by":"publisher","DOI":"10.1111\/ced.13092"},{"key":"e_1_2_8_43_1","doi-asserted-by":"publisher","DOI":"10.1111\/bjd.13633"},{"key":"e_1_2_8_44_1","first-page":"577","volume":"42","author":"D\u00f6pp R.","year":"2000","journal-title":"J. Am. Acad. Dermatol."},{"key":"e_1_2_8_45_1","doi-asserted-by":"publisher","DOI":"10.1586\/1744666X.2016.1123092"},{"key":"e_1_2_8_46_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jim.2009.04.013"},{"key":"e_1_2_8_47_1","doi-asserted-by":"publisher","DOI":"10.1001\/archdermatol.2007.9"},{"key":"e_1_2_8_48_1","doi-asserted-by":"publisher","DOI":"10.1001\/jamadermatol.2016.3357"},{"key":"e_1_2_8_49_1","doi-asserted-by":"publisher","DOI":"10.2340\/00015555-2101"},{"key":"e_1_2_8_50_1","doi-asserted-by":"crossref","first-page":"3642","DOI":"10.4049\/jimmunol.157.8.3642","volume":"157","author":"Delaporte E.","year":"1996","journal-title":"J. Immunol."},{"key":"e_1_2_8_51_1","doi-asserted-by":"publisher","DOI":"10.1046\/j.1523-1747.2003.12146.x"},{"key":"e_1_2_8_52_1","doi-asserted-by":"publisher","DOI":"10.4049\/jimmunol.1001753"},{"key":"e_1_2_8_53_1","first-page":"111","volume":"31","author":"Messingham K. A. N.","year":"2012","journal-title":"Hybrid 2005"},{"key":"e_1_2_8_54_1","doi-asserted-by":"publisher","DOI":"10.1038\/sj.jid.5700958"},{"key":"e_1_2_8_55_1","doi-asserted-by":"publisher","DOI":"10.1038\/sj.jid.5700681"},{"key":"e_1_2_8_56_1","doi-asserted-by":"publisher","DOI":"10.1001\/archdermatol.2012.1604"},{"key":"e_1_2_8_57_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jaci.2008.11.035"},{"key":"e_1_2_8_58_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jaad.2014.04.053"},{"key":"e_1_2_8_59_1","doi-asserted-by":"publisher","DOI":"10.1111\/jdv.13758"},{"key":"e_1_2_8_60_1","first-page":"768","volume":"96","author":"Cozzani E.","year":"2016","journal-title":"Acta Derm. Venereol."},{"key":"e_1_2_8_61_1","doi-asserted-by":"publisher","DOI":"10.1001\/jamadermatol.2013.1434"},{"key":"e_1_2_8_62_1","doi-asserted-by":"publisher","DOI":"10.1111\/bjd.13874"},{"key":"e_1_2_8_63_1","doi-asserted-by":"publisher","DOI":"10.1001\/archderm.138.3.370"},{"key":"e_1_2_8_64_1","doi-asserted-by":"crossref","first-page":"1102","DOI":"10.1001\/archderm.1997.03890450048006","volume":"133","author":"Ghohestani R. F.","year":"1997","journal-title":"Arch. Dermatol."},{"key":"e_1_2_8_65_1","doi-asserted-by":"publisher","DOI":"10.1046\/j.1365-2133.2001.04471.x"},{"key":"e_1_2_8_66_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.clim.2004.04.010"},{"key":"e_1_2_8_67_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2133.2005.06998.x"},{"key":"e_1_2_8_68_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jaad.2016.11.002"},{"key":"e_1_2_8_69_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2133.2012.10820.x"},{"key":"e_1_2_8_70_1","doi-asserted-by":"publisher","DOI":"10.1016\/0190-9622(92)70161-8"},{"key":"e_1_2_8_71_1","doi-asserted-by":"publisher","DOI":"10.1001\/archdermatol.2011.21"},{"key":"e_1_2_8_72_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.clim.2003.12.007"},{"key":"e_1_2_8_73_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1749-6632.2009.04630.x"},{"key":"e_1_2_8_74_1","doi-asserted-by":"crossref","first-page":"155","DOI":"10.1684\/ejd.2015.2719","volume":"26","author":"Hayakawa T.","year":"2016","journal-title":"Eur. J. Dermatol. EJD"},{"key":"e_1_2_8_75_1","doi-asserted-by":"publisher","DOI":"10.1038\/jid.2011.180"},{"key":"e_1_2_8_76_1","doi-asserted-by":"publisher","DOI":"10.1046\/j.1523-1747.1998.00107.x"},{"key":"e_1_2_8_77_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.humimm.2014.01.005"},{"key":"e_1_2_8_78_1","doi-asserted-by":"publisher","DOI":"10.1111\/1523-1747.ep12358276"},{"key":"e_1_2_8_79_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jaut.2004.09.007"},{"key":"e_1_2_8_80_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jdermsci.2007.08.008"},{"key":"e_1_2_8_81_1","doi-asserted-by":"publisher","DOI":"10.1001\/archderm.141.6.691"},{"key":"e_1_2_8_82_1","doi-asserted-by":"crossref","first-page":"119","DOI":"10.47102\/annals-acadmedsg.V44N4p119","volume":"44","author":"Cai S. C. S.","year":"2015","journal-title":"Ann. Acad. Med. Singapore"},{"key":"e_1_2_8_83_1","doi-asserted-by":"publisher","DOI":"10.1007\/s004030050259"},{"key":"e_1_2_8_84_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0923-1811(97)00044-3"},{"key":"e_1_2_8_85_1","doi-asserted-by":"publisher","DOI":"10.1006\/cyto.2000.0791"},{"key":"e_1_2_8_86_1","doi-asserted-by":"publisher","DOI":"10.1046\/j.0022-202x.2001.01505.x"},{"key":"e_1_2_8_87_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1600-0625.1998.tb00317.x"},{"key":"e_1_2_8_88_1","doi-asserted-by":"publisher","DOI":"10.1046\/j.1365-2133.1998.02169.x"},{"key":"e_1_2_8_89_1","doi-asserted-by":"publisher","DOI":"10.1080\/000155500750012162"},{"key":"e_1_2_8_90_1","doi-asserted-by":"publisher","DOI":"10.1007\/BF00372588"},{"key":"e_1_2_8_91_1","doi-asserted-by":"publisher","DOI":"10.1007\/s004030050272"},{"key":"e_1_2_8_92_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2133.2006.07601.x"},{"key":"e_1_2_8_93_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00403-006-0661-5"},{"key":"e_1_2_8_94_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jdermsci.2006.06.002"},{"key":"e_1_2_8_95_1","doi-asserted-by":"publisher","DOI":"10.1111\/jdv.12719"},{"key":"e_1_2_8_96_1","doi-asserted-by":"publisher","DOI":"10.1046\/j.1365-2133.2003.05066.x"},{"key":"e_1_2_8_97_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2133.2008.08979.x"},{"key":"e_1_2_8_98_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2249.2011.04464.x"},{"key":"e_1_2_8_99_1","doi-asserted-by":"publisher","DOI":"10.1046\/j.1365-2133.2000.03599.x"},{"key":"e_1_2_8_100_1","first-page":"27","volume":"12","author":"Frezzolini A.","year":"2002","journal-title":"Eur. J. Dermatol. EJD"},{"key":"e_1_2_8_101_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.0022-202X.2005.23700.x"},{"key":"e_1_2_8_102_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2133.1980.tb01683.x"},{"key":"e_1_2_8_103_1","doi-asserted-by":"publisher","DOI":"10.1111\/all.13131"},{"key":"e_1_2_8_104_1","doi-asserted-by":"publisher","DOI":"10.1016\/0190-9622(93)70170-X"},{"key":"e_1_2_8_105_1","first-page":"897","volume":"148","author":"Borrego L.","year":"1996","journal-title":"Am. J. Pathol."},{"key":"e_1_2_8_106_1","doi-asserted-by":"publisher","DOI":"10.1111\/jdv.12464"},{"key":"e_1_2_8_107_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41598-017-04687-5"},{"key":"e_1_2_8_108_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1468-3083.1999.tb00801.x"},{"key":"e_1_2_8_109_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jdermsci.2016.04.009"},{"key":"e_1_2_8_110_1","doi-asserted-by":"publisher","DOI":"10.1038\/nri2691"},{"key":"e_1_2_8_111_1","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0068145"},{"key":"e_1_2_8_112_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1600-0625.2011.01378.x"},{"key":"e_1_2_8_113_1","doi-asserted-by":"publisher","DOI":"10.1038\/srep18001"},{"key":"e_1_2_8_114_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1749-6632.1996.tb32587.x"},{"key":"e_1_2_8_115_1","doi-asserted-by":"publisher","DOI":"10.1042\/bj3330457"},{"key":"e_1_2_8_116_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0190-9622(96)80146-0"},{"key":"e_1_2_8_117_1","doi-asserted-by":"publisher","DOI":"10.1111\/jdv.12091"},{"key":"e_1_2_8_118_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41598-017-04687-5"},{"key":"e_1_2_8_119_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0923-1811(99)00016-X"},{"key":"e_1_2_8_120_1","doi-asserted-by":"publisher","DOI":"10.1046\/j.1365-2249.2000.01104.x"},{"key":"e_1_2_8_121_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0161-6420(93)31644-1"},{"key":"e_1_2_8_122_1","doi-asserted-by":"publisher","DOI":"10.1076\/ceyr.16.8.820.8987"},{"key":"e_1_2_8_123_1","first-page":"1449","volume":"15","author":"Lambiase A.","year":"2009","journal-title":"Mol. Vis."},{"key":"e_1_2_8_124_1","doi-asserted-by":"publisher","DOI":"10.1167\/iovs.11-9322"},{"key":"e_1_2_8_125_1","doi-asserted-by":"publisher","DOI":"10.1155\/2013\/812029"},{"key":"e_1_2_8_126_1","doi-asserted-by":"publisher","DOI":"10.1038\/JID.2015.356"},{"key":"e_1_2_8_127_1","doi-asserted-by":"publisher","DOI":"10.1172\/JCI11494"},{"key":"e_1_2_8_128_1","doi-asserted-by":"publisher","DOI":"10.1172\/JCI3693"},{"key":"e_1_2_8_129_1","doi-asserted-by":"publisher","DOI":"10.1084\/jem.169.1.333"},{"key":"e_1_2_8_130_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.cyto.2016.05.010"},{"key":"e_1_2_8_131_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.cyto.2017.05.014"}],"container-title":["Experimental Dermatology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1111%2Fexd.13459","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/exd.13459","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,9,13]],"date-time":"2023-09-13T08:42:10Z","timestamp":1694594530000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1111\/exd.13459"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2017,12]]},"references-count":130,"journal-issue":{"issue":"12","published-print":{"date-parts":[[2017,12]]}},"alternative-id":["10.1111\/exd.13459"],"URL":"https:\/\/doi.org\/10.1111\/exd.13459","archive":["Portico"],"relation":{"has-review":[{"id-type":"doi","id":"10.3410\/f.732080539.793549780","asserted-by":"object"}]},"ISSN":["0906-6705","1600-0625"],"issn-type":[{"value":"0906-6705","type":"print"},{"value":"1600-0625","type":"electronic"}],"subject":[],"published":{"date-parts":[[2017,12]]}}}