{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,3]],"date-time":"2026-06-03T13:01:17Z","timestamp":1780491677910,"version":"3.54.1"},"reference-count":13,"publisher":"Wiley","issue":"2","license":[{"start":{"date-parts":[[2017,12,18]],"date-time":"2017-12-18T00:00:00Z","timestamp":1513555200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Experimental Dermatology"],"published-print":{"date-parts":[[2018,2]]},"abstract":"Abstract<\/jats:title>The skin\u2010associated chemokine CTACK<\/jats:styled-content> plays a key role in many inflammatory conditions and could be instrumental in the pathophysiology of tissue\u2010specific immunological diseases such as oral lichen planus (OLP<\/jats:styled-content>). In this study, we investigated, by RT<\/jats:styled-content>\u2010PCR<\/jats:styled-content>, ELISA<\/jats:styled-content>, chemotaxis assays, and fluorescence\u2010activated cell sorting (FACS<\/jats:styled-content>), the production of CTACK<\/jats:styled-content> in oral keratinocytes, its expression in tissues from normal and OLP<\/jats:styled-content> patients, and its role in T\u2010cell recruitment.<\/jats:bold>CTACK<\/jats:styled-content> was produced by the oral epithelium, and it affects chemotaxis of memory CLA<\/jats:styled-content>+ cells to the oral epithelium. CTACK mRNA<\/jats:styled-content> was expressed constitutively in primary oral epithelium and was increased during pro\u2010inflammatory IFN<\/jats:styled-content>\u2010\u03b3 treatment. We found a constitutive production of CTACK<\/jats:styled-content> at a protein level in oral primary cells that increased after IFN<\/jats:styled-content>\u2010\u03b3 treatment. Moreover, we confirmed that CTACK<\/jats:styled-content> attracts memory T cells and those T cells that express CLA<\/jats:styled-content> above the level of basal migration.<\/jats:p>","DOI":"10.1111\/exd.13471","type":"journal-article","created":{"date-parts":[[2017,11,24]],"date-time":"2017-11-24T05:56:41Z","timestamp":1511503001000},"page":"207-210","source":"Crossref","is-referenced-by-count":8,"title":["Oral keratinocytes synthesize CTACK<\/scp>: A new insight into the pathophysiology of the oral mucosa"],"prefix":"10.1111","volume":"27","author":[{"given":"Alison","family":"Marshall","sequence":"first","affiliation":[{"name":"University College London UCL Eastman Dental Institute London UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-4293-2511","authenticated-orcid":false,"given":"Antonio","family":"Celentano","sequence":"additional","affiliation":[{"name":"Melbourne Dental School, Oral Health CRC The University of Melbourne Melbourne Vic. Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nicola","family":"Cirillo","sequence":"additional","affiliation":[{"name":"Melbourne Dental School, Oral Health CRC The University of Melbourne Melbourne Vic. Australia"},{"name":"Centre for Innovation, Research, Education and Health (IRIS) Caposele Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Michael","family":"McCullough","sequence":"additional","affiliation":[{"name":"Melbourne Dental School, Oral Health CRC The University of Melbourne Melbourne Vic. Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Stephen","family":"Porter","sequence":"additional","affiliation":[{"name":"University College London UCL Eastman Dental Institute London UK"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2017,12,18]]},"reference":[{"key":"e_1_2_2_2_1","doi-asserted-by":"publisher","DOI":"10.1016\/S1074-7613(01)00261-8"},{"key":"e_1_2_2_3_1","doi-asserted-by":"publisher","DOI":"10.1111\/jop.12142"},{"key":"e_1_2_2_4_1","doi-asserted-by":"publisher","DOI":"10.2334\/josnusd.16-0334"},{"key":"e_1_2_2_5_1","doi-asserted-by":"publisher","DOI":"10.1111\/eos.12293"},{"key":"e_1_2_2_6_1","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.96.25.14470"},{"key":"e_1_2_2_7_1","doi-asserted-by":"publisher","DOI":"10.1038\/nm0202-157"},{"key":"e_1_2_2_8_1","doi-asserted-by":"publisher","DOI":"10.1084\/jem.194.10.1541"},{"key":"e_1_2_2_9_1","doi-asserted-by":"publisher","DOI":"10.1046\/j.1365-2567.1999.00855.x"},{"key":"e_1_2_2_10_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1600-0714.1997.tb00239.x"},{"key":"e_1_2_2_11_1","doi-asserted-by":"publisher","DOI":"10.1002\/jcp.24643"},{"key":"e_1_2_2_12_1","doi-asserted-by":"publisher","DOI":"10.1067\/mjd.2002.119648"},{"key":"e_1_2_2_13_1","doi-asserted-by":"publisher","DOI":"10.1093\/carcin\/12.2.277"},{"key":"e_1_2_2_14_1","doi-asserted-by":"publisher","DOI":"10.1002\/path.1711600313"}],"container-title":["Experimental Dermatology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1111%2Fexd.13471","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/exd.13471","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,9,24]],"date-time":"2023-09-24T00:54:15Z","timestamp":1695516855000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1111\/exd.13471"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2017,12,18]]},"references-count":13,"journal-issue":{"issue":"2","published-print":{"date-parts":[[2018,2]]}},"alternative-id":["10.1111\/exd.13471"],"URL":"https:\/\/doi.org\/10.1111\/exd.13471","archive":["Portico"],"relation":{},"ISSN":["0906-6705","1600-0625"],"issn-type":[{"value":"0906-6705","type":"print"},{"value":"1600-0625","type":"electronic"}],"subject":[],"published":{"date-parts":[[2017,12,18]]}}}