{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,1,8]],"date-time":"2026-01-08T21:45:59Z","timestamp":1767908759867,"version":"3.49.0"},"reference-count":10,"publisher":"Wiley","issue":"2","license":[{"start":{"date-parts":[[2017,12,21]],"date-time":"2017-12-21T00:00:00Z","timestamp":1513814400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Experimental Dermatology"],"published-print":{"date-parts":[[2018,2]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>Data on <jats:italic><jats:styled-content style=\"fixed-case\">BRAF<\/jats:styled-content><\/jats:italic>,<jats:italic> <jats:styled-content style=\"fixed-case\">NRAS<\/jats:styled-content><\/jats:italic> and <jats:italic><jats:styled-content style=\"fixed-case\">KIT<\/jats:styled-content><\/jats:italic> mutations are scarce in patients with vulvo\u2010vaginal melanomas and are associated with important therapeutic issues. We investigated their prevalence in a cohort of patients with female lower genital tract melanomas between 2003 and 2017. Of the 22 patients, 5 (22.7%) harboured a <jats:italic><jats:styled-content style=\"fixed-case\">BRAF<\/jats:styled-content><\/jats:italic> mutation, which was much higher than the rate of 5% reported in the literature. One patient, who was tested negative on the primary melanoma, had a <jats:italic><jats:styled-content style=\"fixed-case\">NRAS<\/jats:styled-content><\/jats:italic> mutation in a cutaneous metastasis. Our data provide a rationale for prospective and repeated mutations testing in female lower genital tract melanomas.<\/jats:p>","DOI":"10.1111\/exd.13472","type":"journal-article","created":{"date-parts":[[2017,11,25]],"date-time":"2017-11-25T16:22:37Z","timestamp":1511626957000},"page":"210-213","source":"Crossref","is-referenced-by-count":20,"title":["<i><scp>BRAF<\/scp><\/i> mutations might be more common than supposed in vulvar melanomas"],"prefix":"10.1111","volume":"27","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-3301-0195","authenticated-orcid":false,"given":"Sophie","family":"Wylomanski","sequence":"first","affiliation":[{"name":"Department of Obstetrics and Gynecology Nantes University Hospital  Nantes France"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Marc G.","family":"Denis","sequence":"additional","affiliation":[{"name":"INSERM U 1232  Nantes France"},{"name":"Department of Biochemistry Nantes University Hospital  Nantes France"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Sandrine","family":"Th\u00e9oleyre","sequence":"additional","affiliation":[{"name":"INSERM U 1232  Nantes France"},{"name":"Department of Biochemistry Nantes University Hospital  Nantes France"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"R\u00e9jane","family":"Bouquin","sequence":"additional","affiliation":[{"name":"Department of Obstetrics and Gynecology Nantes University Hospital  Nantes France"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Audrey","family":"Vall\u00e9e","sequence":"additional","affiliation":[{"name":"INSERM U 1232  Nantes France"},{"name":"Department of Biochemistry Nantes University Hospital  Nantes France"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Anne\u2010Chantal","family":"Knol","sequence":"additional","affiliation":[{"name":"INSERM U 1232  Nantes France"},{"name":"Immuno\u2010Dermatology Laboratory Nantes University Hospital  Nantes France"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"M\u00e9lanie","family":"Saint\u2010Jean","sequence":"additional","affiliation":[{"name":"INSERM U 1232  Nantes France"},{"name":"Immuno\u2010Dermatology Laboratory Nantes University Hospital  Nantes France"},{"name":"Department of Dermatology Nantes University Hospital  Nantes France"},{"name":"INSERM CIC 1413 Clinical Investigation Center Nantes University Hospital  Nantes France"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Lucie","family":"Peuvrel","sequence":"additional","affiliation":[{"name":"INSERM U 1232  Nantes France"},{"name":"Immuno\u2010Dermatology Laboratory Nantes University Hospital  Nantes France"},{"name":"Department of Dermatology Nantes University Hospital  Nantes France"},{"name":"INSERM CIC 1413 Clinical Investigation Center Nantes University Hospital  Nantes 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