{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,27]],"date-time":"2026-09-27T23:53:17Z","timestamp":1790553197276,"version":"4.1.0"},"reference-count":13,"publisher":"Wiley","issue":"2","license":[{"start":{"date-parts":[[2017,12,18]],"date-time":"2017-12-18T00:00:00Z","timestamp":1513555200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/501100004837","name":"Spanish Ministerio de Ciencia e Innovaci\u00f3n","doi-asserted-by":"crossref","award":["SAF2014-59474-R"],"award-info":[{"award-number":["SAF2014-59474-R"]}],"id":[{"id":"10.13039\/501100004837","id-type":"DOI","asserted-by":"crossref"}]},{"name":"ADMIRE COST Action","award":["BM-1301"],"award-info":[{"award-number":["BM-1301"]}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Experimental Dermatology"],"published-print":{"date-parts":[[2018,2]]},"abstract":"Abstract<\/jats:title>\n \n We recently demonstrated that blockade of the mineralocorticoid receptor (MR) effectively ameliorated GC\u2010induced skin atrophy in healthy human skin explants and epidermal MR knockout mice. However, whether MR blockade improves the therapeutic index of glucocorticoids (GCs) in skin pathology was not investigated. We assessed the effects of GCs, MR antagonists (MRA) or both, in SDS\u2010treated human skin explants. All treatments restored SDS\u2010augmented epidermal thickness but only GC plus MRA restored the expression of\n COL1A1<\/jats:italic>\n . However, MRA alone or in combination with GCs may exert a dual role in regulating inflammatory cytokines. Thus, although combined treatment may be beneficial to improve irritative skin, extensive in vivo testing is required to establish whether the anti\u2010inflammatory effects of GCs are maintained in the presence of MRA.\n <\/jats:p>","DOI":"10.1111\/exd.13473","type":"journal-article","created":{"date-parts":[[2017,11,27]],"date-time":"2017-11-27T09:50:12Z","timestamp":1511776212000},"page":"185-187","source":"Crossref","is-referenced-by-count":16,"title":["Mineralocorticoid receptor blockade improves glucocorticoid\u2010induced skin atrophy but partially ameliorates anti\u2010inflammatory actions in an irritative model in human skin explants"],"prefix":"10.1111","volume":"27","author":[{"given":"Julia","family":"Boix","sequence":"first","affiliation":[{"name":"Instituto de Biomedicina de Valencia Consejo Superior de Investigaciones Cient\u00edficas (IBV\u2010CSIC) Valencia Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Van Tuan","family":"Nguyen","sequence":"additional","affiliation":[{"name":"UMR 1138 INSERM Centre de Recherche des Cordeliers Paris France"},{"name":"Basic Science Department Thai Nguyen University of Agriculture and Forestry Thai Nguyen Vietnam"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nicolette","family":"Farman","sequence":"additional","affiliation":[{"name":"UMR 1138 INSERM Centre de Recherche des Cordeliers Paris France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"S\u00e9lim","family":"Aractingi","sequence":"additional","affiliation":[{"name":"H\u00f4pital Cochin Tarnier D\u00e9partement de Dermatologie Universit\u00e9 Paris Descartes Paris France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-7166-2824","authenticated-orcid":false,"given":"Paloma","family":"P\u00e9rez","sequence":"additional","affiliation":[{"name":"Instituto de Biomedicina de Valencia Consejo Superior de Investigaciones Cient\u00edficas (IBV\u2010CSIC) Valencia Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2017,12,18]]},"reference":[{"key":"e_1_2_9_2_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.0906-6705.2006.00435.x"},{"key":"e_1_2_9_3_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.mce.2007.05.014"},{"key":"e_1_2_9_4_1","doi-asserted-by":"publisher","DOI":"10.1111\/exd.12376"},{"key":"e_1_2_9_5_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.steroids.2015.04.006"},{"key":"e_1_2_9_6_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jid.2016.07.018"},{"key":"e_1_2_9_7_1","doi-asserted-by":"publisher","DOI":"10.1038\/jid.2015.44"},{"key":"e_1_2_9_8_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1600-0536.1997.tb00369.x"},{"key":"e_1_2_9_9_1","first-page":"2201","volume":"130","author":"Clemmensen A.","year":"2010","journal-title":"Dermatol."},{"key":"e_1_2_9_10_1","doi-asserted-by":"publisher","DOI":"10.1080\/01926230701481907"},{"key":"e_1_2_9_11_1","doi-asserted-by":"publisher","DOI":"10.1038\/jid.2010.155"},{"key":"e_1_2_9_12_1","doi-asserted-by":"publisher","DOI":"10.1155\/2012\/781375"},{"key":"e_1_2_9_13_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0887-2333(03)00019-5"},{"key":"e_1_2_9_14_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.mce.2010.04.005"}],"container-title":["Experimental Dermatology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1111%2Fexd.13473","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/exd.13473","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,9,23]],"date-time":"2023-09-23T20:54:32Z","timestamp":1695502472000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1111\/exd.13473"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2017,12,18]]},"references-count":13,"journal-issue":{"issue":"2","published-print":{"date-parts":[[2018,2]]}},"alternative-id":["10.1111\/exd.13473"],"URL":"https:\/\/doi.org\/10.1111\/exd.13473","archive":["Portico"],"relation":{},"ISSN":["0906-6705","1600-0625"],"issn-type":[{"value":"0906-6705","type":"print"},{"value":"1600-0625","type":"electronic"}],"subject":[],"published":{"date-parts":[[2017,12,18]]}}}