{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,15]],"date-time":"2026-07-15T15:08:00Z","timestamp":1784128080459,"version":"3.55.0"},"reference-count":8,"publisher":"Wiley","issue":"2","license":[{"start":{"date-parts":[[2017,12,21]],"date-time":"2017-12-21T00:00:00Z","timestamp":1513814400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/100000002","name":"National Institutes of Health","doi-asserted-by":"publisher","award":["5P50CA121973\u201008"],"award-info":[{"award-number":["5P50CA121973\u201008"]}],"id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100005646","name":"Actelion Pharmaceuticals","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100005646","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Experimental Dermatology"],"published-print":{"date-parts":[[2018,2]]},"abstract":"Abstract<\/jats:title>While mycosis fungoides (MF<\/jats:styled-content>) is typically an indolent malignancy, it may infrequently undertake an aggressive course. We used proteomic analyses to identify a biomarker of the aggressive course of MF<\/jats:styled-content>. Results of this investigation demonstrated that PARP<\/jats:styled-content>\u20101, heat\u2010shock protein family A (Hsp70) member 1 like (HSAP<\/jats:styled-content>1L), Hsp70 member 1A (HSPA<\/jats:styled-content>1A), ATP<\/jats:styled-content>\u2010depending RNA<\/jats:styled-content> helicase (DDX<\/jats:styled-content>17) and the \u03b1\u2010isoform of lamina\u2010associated polypeptide 2 (TMPO<\/jats:styled-content>) had higher expression in aggressive disease versus non\u2010aggressive. Moreover, PARP<\/jats:styled-content>\u20101 was overexpressed in patients with early stage of MF<\/jats:styled-content> who developed later an aggressive disease. PARP<\/jats:styled-content>\u20101 was evaluated as a new target for therapy, demonstrating the selective dose\u2010dependent cytotoxic effect of PARP<\/jats:styled-content> inhibitors on S\u00e9zary cells in comparison with non\u2010malignant lymphocytes. In conclusion, we believe that PARP<\/jats:styled-content>\u20101 may serve not only as a biomarker at initial biopsies for a disease that may become aggressive but also as a new therapeutic target of advanced MF<\/jats:styled-content> and S\u00e9zary syndrome.<\/jats:p>","DOI":"10.1111\/exd.13477","type":"journal-article","created":{"date-parts":[[2017,12,5]],"date-time":"2017-12-05T13:40:02Z","timestamp":1512481202000},"page":"188-190","source":"Crossref","is-referenced-by-count":10,"title":["Therapeutic and prognostic significance of PARP<\/scp>\u20101 in advanced mycosis fungoides and Sezary syndrome"],"prefix":"10.1111","volume":"27","author":[{"given":"David","family":"Lemchak","sequence":"first","affiliation":[{"name":"Department of Dermatology University of Pittsburgh Pittsburgh PA USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Swati","family":"Banerjee","sequence":"additional","affiliation":[{"name":"Department of Dermatology University of Pittsburgh Pittsburgh PA USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shaunak S.","family":"Digambar","sequence":"additional","affiliation":[{"name":"Department of Dermatology University of Pittsburgh Pittsburgh PA USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Brian L.","family":"Hood","sequence":"additional","affiliation":[{"name":"University of Pittsburgh Cancer Institute University of Pittsburgh Pittsburgh PA USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Thomas P.","family":"Conrads","sequence":"additional","affiliation":[{"name":"University of Pittsburgh Cancer Institute University of Pittsburgh Pittsburgh PA USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jaroslaw","family":"Jedrych","sequence":"additional","affiliation":[{"name":"Department of Dermatology University of Pittsburgh Pittsburgh PA USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Larisa","family":"Geskin","sequence":"additional","affiliation":[{"name":"Department of Dermatology University of Pittsburgh Pittsburgh PA USA"},{"name":"Department of Dermatology Columbia University New York NY USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-1339-5710","authenticated-orcid":false,"given":"Oleg E.","family":"Akilov","sequence":"additional","affiliation":[{"name":"Department of Dermatology University of Pittsburgh Pittsburgh PA USA"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2017,12,21]]},"reference":[{"key":"e_1_2_9_2_1","doi-asserted-by":"publisher","DOI":"10.1001\/archderm.139.7.857"},{"key":"e_1_2_9_3_1","doi-asserted-by":"publisher","DOI":"10.1074\/mcp.M500102-MCP200"},{"key":"e_1_2_9_4_1","doi-asserted-by":"publisher","DOI":"10.1074\/mcp.M800518-MCP200"},{"key":"e_1_2_9_5_1","doi-asserted-by":"publisher","DOI":"10.1365\/s10337-003-0182-8"},{"key":"e_1_2_9_6_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0022-1759(00)00238-6"},{"key":"e_1_2_9_7_1","doi-asserted-by":"publisher","DOI":"10.5114\/pjp.2015.54957"},{"key":"e_1_2_9_8_1","doi-asserted-by":"publisher","DOI":"10.3892\/ol.2016.5226"},{"key":"e_1_2_9_9_1","doi-asserted-by":"publisher","DOI":"10.1186\/s13045-015-0217-2"}],"container-title":["Experimental Dermatology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1111%2Fexd.13477","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/exd.13477","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,9,24]],"date-time":"2023-09-24T00:54:30Z","timestamp":1695516870000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1111\/exd.13477"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2017,12,21]]},"references-count":8,"journal-issue":{"issue":"2","published-print":{"date-parts":[[2018,2]]}},"alternative-id":["10.1111\/exd.13477"],"URL":"https:\/\/doi.org\/10.1111\/exd.13477","archive":["Portico"],"relation":{},"ISSN":["0906-6705","1600-0625"],"issn-type":[{"value":"0906-6705","type":"print"},{"value":"1600-0625","type":"electronic"}],"subject":[],"published":{"date-parts":[[2017,12,21]]}}}