{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,2,21]],"date-time":"2025-02-21T07:52:17Z","timestamp":1740124337276,"version":"3.37.3"},"reference-count":32,"publisher":"Wiley","issue":"2","license":[{"start":{"date-parts":[[2018,1,5]],"date-time":"2018-01-05T00:00:00Z","timestamp":1515110400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"name":"Korea Health Technology R&D Project","award":["A121795"],"award-info":[{"award-number":["A121795"]}]},{"name":"Ministry of Health & Welfare, Republic of Korea","award":["A121795"],"award-info":[{"award-number":["A121795"]}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Experimental Dermatology"],"published-print":{"date-parts":[[2018,2]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>Psoriasis is largely mediated by interleukin (<jats:styled-content style=\"fixed-case\">IL<\/jats:styled-content>)\u201023\/T helper (Th) 17 axis, and <jats:styled-content style=\"fixed-case\">IL<\/jats:styled-content>\u201021 is a pleiotropic cytokine expressed by Th17 cells. Despite previously reported possible pathogenic roles of <jats:styled-content style=\"fixed-case\">IL<\/jats:styled-content>\u201021 in human psoriasis, we found that <jats:styled-content style=\"fixed-case\">IL<\/jats:styled-content>\u201021 receptor (<jats:styled-content style=\"fixed-case\">IL<\/jats:styled-content>\u201021R) signalling was not crucial for imiquimod\u2010induced psoriatic inflammation, using <jats:styled-content style=\"fixed-case\">IL<\/jats:styled-content>\u201021R<jats:sup><jats:italic>\u2212\/\u2212<\/jats:italic><\/jats:sup> mice. The severity of imiquimod\u2010induced psoriatic manifestation and pro\u2010inflammatory Th17 cytokine levels, <jats:styled-content style=\"fixed-case\">IL<\/jats:styled-content>\u201017A\u2010producing \u03b3\u03b4 T cells and <jats:styled-content style=\"fixed-case\">CD<\/jats:styled-content>4+ T cells, and in vitro <jats:styled-content style=\"fixed-case\">IL<\/jats:styled-content>\u201017A production by \u03b3\u03b4 T cells after <jats:styled-content style=\"fixed-case\">IL<\/jats:styled-content>\u201023 stimulation was comparable between wild\u2010type and <jats:styled-content style=\"fixed-case\">IL<\/jats:styled-content>\u201021R<jats:sup><jats:italic>\u2212\/\u2212<\/jats:italic><\/jats:sup> mice. Collectively, <jats:styled-content style=\"fixed-case\">IL<\/jats:styled-content>\u201021R signalling was not critically involved in <jats:styled-content style=\"fixed-case\">IMQ<\/jats:styled-content>\u2010induced psoriatic inflammation despite an increased <jats:styled-content style=\"fixed-case\">IL<\/jats:styled-content>\u201021 expression in the <jats:styled-content style=\"fixed-case\">IMQ<\/jats:styled-content>\u2010treated mouse skin. Our data may represent the significant differences between human psoriasis and murine psoriasis model, and further studies using other models will be required to elucidate the role of <jats:styled-content style=\"fixed-case\">IL<\/jats:styled-content>\u201021 in psoriasis pathogenesis.<\/jats:p>","DOI":"10.1111\/exd.13481","type":"journal-article","created":{"date-parts":[[2017,12,9]],"date-time":"2017-12-09T02:31:06Z","timestamp":1512786666000},"page":"191-195","source":"Crossref","is-referenced-by-count":6,"title":["Interleukin\u201021 receptor signalling is not critically required for imiquimod\u2010induced psoriasiform dermatitis in mice"],"prefix":"10.1111","volume":"27","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-1585-8184","authenticated-orcid":false,"given":"Hee Joo","family":"Kim","sequence":"first","affiliation":[{"name":"Department of dermatology Gachon University Gil Medical Center  Incheon Korea"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Sung Hee","family":"Kim","sequence":"additional","affiliation":[{"name":"Department of dermatology Severance hospital Cutaneous Biology Research Institute and Brain Korea 21 PLUS Project for Medical Science Yonsei University College of Medicine  Seoul Korea"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Tae\u2010Gyun","family":"Kim","sequence":"additional","affiliation":[{"name":"Department of dermatology Severance hospital Cutaneous Biology Research Institute and Brain Korea 21 PLUS Project for Medical Science Yonsei University College of Medicine  Seoul Korea"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Je Yun","family":"Park","sequence":"additional","affiliation":[{"name":"Department of dermatology Severance hospital Cutaneous Biology Research Institute and Brain Korea 21 PLUS Project for Medical Science Yonsei University College of Medicine  Seoul Korea"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Minseok","family":"Lee","sequence":"additional","affiliation":[{"name":"Department of dermatology Severance hospital Cutaneous Biology Research Institute and Brain Korea 21 PLUS Project for Medical Science Yonsei University College of Medicine  Seoul Korea"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Dae Suk","family":"Kim","sequence":"additional","affiliation":[{"name":"Department of dermatology Severance hospital Cutaneous Biology Research Institute and Brain Korea 21 PLUS Project for Medical Science Yonsei University College of Medicine  Seoul Korea"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Min\u2010Geol","family":"Lee","sequence":"additional","affiliation":[{"name":"Department of dermatology Severance hospital Cutaneous Biology Research Institute and Brain Korea 21 PLUS Project for Medical Science Yonsei University College of Medicine  Seoul Korea"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2018,1,5]]},"reference":[{"key":"e_1_2_9_2_1","doi-asserted-by":"publisher","DOI":"10.1038\/35040504"},{"key":"e_1_2_9_3_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.cytogfr.2009.02.002"},{"key":"e_1_2_9_4_1","doi-asserted-by":"publisher","DOI":"10.1038\/nm.1995"},{"key":"e_1_2_9_5_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jdermsci.2010.08.016"},{"key":"e_1_2_9_6_1","doi-asserted-by":"publisher","DOI":"10.1038\/nature05970"},{"key":"e_1_2_9_7_1","doi-asserted-by":"publisher","DOI":"10.4049\/jimmunol.178.2.732"},{"key":"e_1_2_9_8_1","first-page":"496","volume":"361","author":"Nestle F. 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