{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,23]],"date-time":"2026-10-23T21:21:35Z","timestamp":1792790495887,"version":"4.5.0"},"reference-count":42,"publisher":"Wiley","issue":"2","license":[{"start":{"date-parts":[[2018,1,5]],"date-time":"2018-01-05T00:00:00Z","timestamp":1515110400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"name":"Swiss National Foundation","award":["310030_135742"],"award-info":[{"award-number":["310030_135742"]}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Experimental Dermatology"],"published-print":{"date-parts":[[2018,2]]},"abstract":"Abstract<\/jats:title>Hidradenitis suppurativa (HS<\/jats:styled-content>) is an inflammatory skin disease with poorly understood immunopathogenic mechanisms. LL<\/jats:styled-content>\u201037 is an antimicrobial peptide, which is transcribed from the CAMP<\/jats:styled-content> (cathelicidin antimicrobial peptide) gene. Previous reports showed upregulated levels of CAMP<\/jats:styled-content> and LL<\/jats:styled-content>\u201037 in HS<\/jats:styled-content> lesions, and therefore, the aim of this study was to compare levels of LL<\/jats:styled-content>\u201037 in HS<\/jats:styled-content> to other inflammatory skin diseases and to establish immunomodulatory functions of LL<\/jats:styled-content>\u201037 in HS<\/jats:styled-content>. We confirm an upregulation of the LL<\/jats:styled-content>\u201037 peptide in lesional HS<\/jats:styled-content> skin with comparable levels as in psoriasis patients and are able to positively correlate the presence of LL<\/jats:styled-content>\u201037 in HS<\/jats:styled-content> with the presence of T cells, macrophages, neutrophils, IFN<\/jats:styled-content>\u2010\u03b3, IL<\/jats:styled-content>\u201017, IL<\/jats:styled-content>\u201023, TNF<\/jats:styled-content>\u2010\u03b1, IL<\/jats:styled-content>\u201032 and IL<\/jats:styled-content>\u20101\u03b2. Mechanistically, LL<\/jats:styled-content>\u201037 boosts the proliferation of unspecifically activated CD<\/jats:styled-content>4+<\/jats:sup> T cells via an increased calcium signalling independent of antigen\u2010presenting cells. Targeting LL<\/jats:styled-content>\u201037 may therefore represent a new therapeutic option for the treatment of this recalcitrant disease, but it has to be kept in mind that LL<\/jats:styled-content>\u201037 also has an antimicrobial function.<\/jats:p>","DOI":"10.1111\/exd.13482","type":"journal-article","created":{"date-parts":[[2017,12,9]],"date-time":"2017-12-09T02:37:43Z","timestamp":1512787063000},"page":"172-177","source":"Crossref","is-referenced-by-count":58,"title":["Elevated levels of the antimicrobial peptide LL<\/scp>\u201037 in hidradenitis suppurativa are associated with a Th1\/Th17 immune response"],"prefix":"10.1111","volume":"27","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-8260-6449","authenticated-orcid":false,"given":"Rahel","family":"Thomi","sequence":"first","affiliation":[{"name":"Department of Dermatology Inselspital, Bern University Hospital University of Bern Bern Switzerland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Christoph","family":"Schlapbach","sequence":"additional","affiliation":[{"name":"Department of Dermatology Inselspital, Bern University Hospital University of Bern Bern Switzerland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nikhil","family":"Yawalkar","sequence":"additional","affiliation":[{"name":"Department of Dermatology Inselspital, Bern University Hospital University of Bern Bern Switzerland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-8965-9407","authenticated-orcid":false,"given":"Dagmar","family":"Simon","sequence":"additional","affiliation":[{"name":"Department of Dermatology Inselspital, Bern University Hospital University of Bern Bern Switzerland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Daniel","family":"Yerly","sequence":"additional","affiliation":[{"name":"Department of Rheumatology, Immunology and Allergology Inselspital, Bern University Hospital University of Bern Bern Switzerland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Robert E.","family":"Hunger","sequence":"additional","affiliation":[{"name":"Department of Dermatology Inselspital, Bern University Hospital University of Bern Bern Switzerland"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2018,1,5]]},"reference":[{"key":"e_1_2_7_2_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jaad.2006.08.061"},{"key":"e_1_2_7_3_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMcp1014163"},{"key":"e_1_2_7_4_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jaad.2015.07.045"},{"key":"e_1_2_7_5_1","first-page":"1017","volume":"15","author":"Kurayev A.","year":"2016","journal-title":"J. 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