{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,18]],"date-time":"2026-09-18T10:43:18Z","timestamp":1789728198211,"version":"4.0.1"},"reference-count":12,"publisher":"Wiley","issue":"6","license":[{"start":{"date-parts":[[2018,4,10]],"date-time":"2018-04-10T00:00:00Z","timestamp":1523318400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Experimental Dermatology"],"published-print":{"date-parts":[[2018,6]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>In this study, we investigated the role of <jats:styled-content style=\"fixed-case\">IL<\/jats:styled-content>\u201026 in allergic contact dermatitis (<jats:styled-content style=\"fixed-case\">ACD<\/jats:styled-content>), highlighting its\u2019 contribute in the cytotoxic mechanism responsible for the tissue injury. <jats:styled-content style=\"fixed-case\">IL<\/jats:styled-content>\u201026 is a signature Th17 cytokine, and immune cells are its predominant sources. Recently, it has shown that Th17 cell\u2010derived\u2010<jats:styled-content style=\"fixed-case\">IL<\/jats:styled-content>\u201026 functions like an antimicrobial peptide. Here, we hypothesized that <jats:styled-content style=\"fixed-case\">IL<\/jats:styled-content>\u201026 could be involved in cytotoxicity mechanism that underlies <jats:styled-content style=\"fixed-case\">ACD<\/jats:styled-content>. Indeed, we have attributed a role to <jats:styled-content style=\"fixed-case\">IL<\/jats:styled-content>\u201026 in this context, through <jats:styled-content style=\"fixed-case\">PBMC<\/jats:styled-content> cytotoxicity assays vs HaCat. To demonstrate that <jats:styled-content style=\"fixed-case\">IL<\/jats:styled-content>\u201026 was effectively involved in this activity, we performed the assay using transfected <jats:styled-content style=\"fixed-case\">ACD PBMC<\/jats:styled-content>s by si<jats:styled-content style=\"fixed-case\">RNA<\/jats:styled-content> for <jats:styled-content style=\"fixed-case\">IL<\/jats:styled-content>\u201026. Indeed, we demonstrated that these cells were less able to kill keratinocytes compared with <jats:styled-content style=\"fixed-case\">ACD PBMC<\/jats:styled-content>s (<jats:italic>P<\/jats:italic>\u00a0&lt;\u00a0.01). In conclusion, our findings support the idea that this emergent cytokine, <jats:styled-content style=\"fixed-case\">IL<\/jats:styled-content>\u201026, is implicated in the killing mechanisms of <jats:styled-content style=\"fixed-case\">KC<\/jats:styled-content> observed during <jats:styled-content style=\"fixed-case\">ACD<\/jats:styled-content>.<\/jats:p>","DOI":"10.1111\/exd.13521","type":"journal-article","created":{"date-parts":[[2018,3,2]],"date-time":"2018-03-02T16:53:25Z","timestamp":1520009605000},"page":"681-684","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":13,"title":["<scp>IL<\/scp>\u201026 in allergic contact dermatitis: Resource in a state of readiness"],"prefix":"10.1111","volume":"27","author":[{"given":"Giuseppina","family":"Caiazzo","sequence":"first","affiliation":[{"name":"Department of Clinical Medicine and Surgery Section of Dermatology University of Naples Federico II  Naples Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Roberta","family":"Di Caprio","sequence":"additional","affiliation":[{"name":"Department of Clinical Medicine and Surgery Section of Dermatology University of Naples Federico II  Naples Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Serena","family":"Lembo","sequence":"additional","affiliation":[{"name":"Department of Medicine, Surgery and Dentistry \u201cScuola Medica Salernitana\u201d University of Salerno  Salerno Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Annunziata","family":"Raimondo","sequence":"additional","affiliation":[{"name":"Department of Clinical Medicine and Surgery Section of Dermatology University of Naples Federico II  Naples Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Emanuele","family":"Scala","sequence":"additional","affiliation":[{"name":"Department of Clinical Medicine and Surgery Section of Dermatology University of Naples Federico II  Naples Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Cataldo","family":"Patruno","sequence":"additional","affiliation":[{"name":"Department of Clinical Medicine and Surgery Section of Dermatology University of Naples Federico II  Naples Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-5485-0172","authenticated-orcid":false,"given":"Anna","family":"Balato","sequence":"additional","affiliation":[{"name":"Department of Advanced Biomedical Sciences University of Naples Federico II  Naples Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2018,4,10]]},"reference":[{"key":"e_1_2_8_2_1","doi-asserted-by":"publisher","DOI":"10.4049\/jimmunol.165.6.3058"},{"key":"e_1_2_8_3_1","doi-asserted-by":"publisher","DOI":"10.1111\/exd.12036"},{"key":"e_1_2_8_4_1","doi-asserted-by":"publisher","DOI":"10.4049\/jimmunol.0901767"},{"key":"e_1_2_8_5_1","doi-asserted-by":"publisher","DOI":"10.1155\/2013\/261037"},{"key":"e_1_2_8_6_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2133.2009.09400.x"},{"key":"e_1_2_8_7_1","doi-asserted-by":"publisher","DOI":"10.1038\/ni1497"},{"key":"e_1_2_8_8_1","doi-asserted-by":"publisher","DOI":"10.1371\/journal.ppat.1005624"},{"key":"e_1_2_8_9_1","doi-asserted-by":"publisher","DOI":"10.1038\/ni.3211"},{"key":"e_1_2_8_10_1","doi-asserted-by":"publisher","DOI":"10.1126\/scitranslmed.3008946"},{"key":"e_1_2_8_11_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0002-9440(10)64027-8"},{"key":"e_1_2_8_12_1","doi-asserted-by":"publisher","DOI":"10.1046\/j.1365-2133.2001.04222.x"},{"key":"e_1_2_8_13_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jid.2016.03.020"}],"container-title":["Experimental Dermatology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1111%2Fexd.13521","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/exd.13521","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,9,16]],"date-time":"2023-09-16T20:25:13Z","timestamp":1694895913000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1111\/exd.13521"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2018,4,10]]},"references-count":12,"journal-issue":{"issue":"6","published-print":{"date-parts":[[2018,6]]}},"alternative-id":["10.1111\/exd.13521"],"URL":"https:\/\/doi.org\/10.1111\/exd.13521","archive":["Portico"],"relation":{},"ISSN":["0906-6705","1600-0625"],"issn-type":[{"value":"0906-6705","type":"print"},{"value":"1600-0625","type":"electronic"}],"subject":[],"published":{"date-parts":[[2018,4,10]]},"assertion":[{"value":"2018-02-23","order":1,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2018-04-10","order":2,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}